Phenols
Medchemexpress LLC Olopatadine hydrochloride | 140462-76-6 | 99.8% | 100 MG
Olopatadine hydrochloride (ALO4943A) is a histamine blocker primarily used in the treatment of allergic conjunctivitis. As a second-generation histamine H1 receptor antagonist, it also demonstrates effectiveness for allergic rhinitis and chronic urticaria. It is characterized by rapid and high absorption, with significant renal clearance in humans.
- Significantly inhibits ear swelling and increased production of IL-4, IL-1beta, IL-6, GM-CSF, and NGF in lesioned ear tissue.
- Inhibits histamine release from human conjunctival mast cell preparations in vitro.
- Attenuates passive anaphylaxis in guinea pig conjunctiva.
Medchemexpress LLC HIF-1α-IN-2 hydrochloride | 98.1% | 397.92 | 10 MG
HIF-1α-IN-2 hydrochloride is an effective HIF-1α inhibitor with anticancer potencies (IC50s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). It suppresses HIF-1α expression by blocking transcription and protein translation.
- Effective HIF-1α inhibitor
- Suppresses HIF-1α expression by blocking transcription and protein translation
- Anticancer potencies (IC50s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells)
Medchemexpress LLC Vernakalant hydrochloride | 748810-28-8 | MFCD09833303 | 99.3% | C20H32ClNO4 | 10MG
Vernakalant hydrochloride is a research chemical that acts as a mixed voltage- and frequency-dependent sodium channel blocker and an atria-preferred potassium channel blocker, used to investigate atrial electrophysiology and arrhythmia mechanisms. It is supplied in solid and DMSO solution formats and is characterized by defined molecular properties for in vitro studies.
- High purity (99.33%).
- Available as solid and 10 mM DMSO solution.
- Suitable for in vitro electrophysiology and pharmacology studies.
- Molecular formula C20H32ClNO4; molecular weight 385.93 g·mol⁻¹.
- For research use only; not for human or veterinary use.
Medchemexpress LLC Quinagolide hydrochloride (CV205-502 hydrochloride) | 94424-50-7 | 99.6% | 432.02 | 100 MG
Quinagolide hydrochloride is a selective and orally active dopamine D2 receptor agonist. It inhibits prolactin and down-regulates AKT levels and its phosphorylation, demonstrating antitumor effects and making it suitable for cancer research.
- Selective and orally active dopamine D2 receptor agonist
- Inhibits prolactin
- Down-regulates AKT levels and its phosphorylation
- Shows antitumor effects
- Reduces non-ergot dopamine receptor 2 (DRD2) mRNA expression
- Inhibits invasive properties and endothelial differentiation of endometrial mesenchymal stromal cells (E-MSCs)
- Effectively inhibits tumor growth in animal models
Medchemexpress LLC Acetaminophen glucuronide sodium salt | 120595-80-4 | MFCD00153898 | ≥99.0% | 349.27 g/mol | C14H16NNaO8 | 1 MG
Acetaminophen glucuronide sodium salt is the sodium salt of the primary glucuronide metabolite of acetaminophen. Supplied as a white to off-white solid, it is used as a reference standard in analytical chemistry, metabolite identification, and toxicology research.
- Primary glucuronide metabolite of acetaminophen.
- Supplied as a white to off-white solid, soluble in water.
- Molecular formula C14H16NNaO8 and molecular weight 349.27 g/mol.
- High purity (≥99.0%).
- Available in small pack sizes for analytical use (1 mg, 5 mg, 10 mg).
- Suitable as an analytical reference, calibration standard, and for toxicology assays.
Apexbio Technology LLC Clemizole hydrochloride 1163-36-6 10mM (in 1mL DMSO)
Clemizole hydrochloride is a histamine H1 receptor antagonist reported to inhibit hepatitis C virus (HCV) replication by targeting the viral NS4B protein a component essential for viral RNA replication Clemizole demonstrates antiviral activity in vitro against HCV genotype 2a subgenomic replicons exhibiting an IC50 value around 8 mM When combined with HCV protease inhibitors (such as VX950 or SCH503034) clemizole displays synergistic antiviral effects In contrast additive antiviral effects occur in combination with interferon ribavirin or polymerase inhibitors Clemizole is utilized in research contexts aimed at evaluating its efficacy potential antiviral combinations metabolism pathways and pharmacokinetics relevant to its consideration as a therapeutic candidate for HCV infection
Medchemexpress LLC UNC9994 hydrochloride | 2108826-33-9 | 99.5% | 457.84 | 10 MG
UNC9994 hydrochloride is a functionally selective, β-arrestin-biased dopamine D2 receptor (D2R) agonist. It selectively activates β-arrestin recruitment and signaling, demonstrating antipsychotic-like activity. It also acts as an antagonist of Gi-regulated cAMP production and a partial agonist for D2R/β-arrestin-2 interactions.
- Selectively activates β-arrestin recruitment and signaling.
- Antagonist of Gi-regulated cAMP production.
- Partial agonist for D2R/β-arrestin-2 interactions.
- Shows antipsychotic-like activity.
- Induces D2-mediated β-arrestin-2 translocation with EC50s of 6.1 nM and 448 nM.
- Acts as an antagonist at 5HT2A and 5HT2B receptors.
- Acts as an agonist at 5HT2C and 5HT1A receptors.
eMolecules 65646-68-6 | Fenretinide | Apollo Scientific | MFCD00792674 | 391.555 | C26H33NO2 | 99.000 | C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(=O)Nc1ccc(O)cc1 | 100mg | 562460510
Fenretinide | Apollo Scientific | 65646-68-6 | MFCD00792674 | 391.555 | C26H33NO2 | 99.000 | C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(=O)Nc1ccc(O)cc1 | 100mg | 562460510
eMolecules 202475-60-3 | JANEX-1 | AstaTech | MFCD01862614 | 297.314 | C16H15N3O3 | 95.000 | COc1cc2ncnc(Nc3ccc(O)cc3)c2cc1OC | 1g | 290663216
JANEX-1 | AstaTech | 202475-60-3 | MFCD01862614 | 297.314 | C16H15N3O3 | 95.000 | COc1cc2ncnc(Nc3ccc(O)cc3)c2cc1OC | 1g | 290663216