Carboxylic acids and derivatives
Apexbio Technology LLC LOXO-101 1223405-08-0 5mg
LOXO-101 (CAS 1223405-08-0) is a potent and selective inhibitor of the tropomyosin receptor kinase (TRK) family demonstrating low nanomolar inhibitory activity across all TRK isoforms LOXO-101 disrupts signaling mediated by neurotrophin receptors which are critical for neuronal development and survival In kinase profiling LOXO-101 exhibited minimal off-target activity with significant inhibition observed only for TNK2 (IC50 576 nM) and did not display hERG inhibition or QT prolongation effects In vivo studies revealed dose-dependent tumor growth suppression in xenograft models Clinically LOXO-101 has been evaluated for safety and pharmacokinetics and induced rapid tumor regression in a TRK fusion-positive patient highlighting its utility in studying TRK-driven malignancies
Medchemexpress LLC Ethyl Lauroyl Argina 5g
Ethyl Lauroyl Arginate Hydrochloride is an arginine derivative[1]
Medchemexpress LLC Rhodamine 101 chloride | 64339-18-0 | 527.05 g/mol | C32H31ClN2O3 | 10 MG
Rhodamine 101 chloride is a bright xanthene-class fluorescent dye with excitation and emission maxima at 565 nm and 595 nm, respectively. It is used for fluorescence microscopy, cellular staining, and as a red-spectrum reference standard. The solid is supplied in small laboratory pack sizes and should be stored protected from light and moisture; in solvent store at -80°C (up to 6 months) or -20°C (up to 1 month).
- Excitation 565 nm and emission 595 nm.
- Suitable for fluorescence microscopy and cellular staining.
- Useful as a reference standard in red-spectrum labeling.
- Available in small lab pack sizes, including 10 mg.
- Store sealed, protected from moisture and light.
Medchemexpress LLC Rhodamine 101 hydrochloride | 64339-18-0 | 95.0% | 563.51 | 25 MG
Rhodamine 101 hydrochloride is a fluorescent dye. It is known for its bright fluorescence and specific excitation and emission characteristics.
- Exhibits bright fluorescence
- Excitation maxima at 565 nm
- Emission maxima at 595 nm.
Medchemexpress LLC Rhodamine 101 hydrochloride | 64339-18-0 | MFCD00210089 | >=95% | 563.51 | 5 MG
Rhodamine 101 chloride (Rhodamine 640 chloride) hydrochloride is a bright fluorescent dye with excitation and emission maxima of 565 and 595 nm, respectively.
- For research use only.
- We do not sell to patients.
Medchemexpress LLC UCPH-101 | 1118460-77-7 | 98.6% | 422.48 | 25 MG
UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM. It is for research use only.
- Inhibits EAAT1 anion currents in a concentration-dependent manner
- Suitable for research applications
Medchemexpress LLC PKUMDL-LC-101-D04 1g | 2143896-83-5 | 378.94 | C14H23ClN4O2S2 | 1 G
PKUMDL-LC-101-D04 is a small-molecule allosteric activator of glutathione peroxidase 4 (GPX4) supplied as a hydrochloride research chemical. It increases GPX4 enzymatic activity (reported pEC50 = 4.7) and has been used in cell and animal studies to inhibit ferroptosis and reduce inflammation. Molecular formula C14H23ClN4O2S2; molecular weight 378.94 Da.
- Allosteric activator of glutathione peroxidase 4 (GPX4).
- Reported activity pEC50 = 4.7 in biochemical assays.
- Hydrochloride salt form for improved stability and handling.
- Molecular formula C14H23ClN4O2S2, molecular weight 378.94 Da.
- Provided as a research reagent; not for human use.
- Typical pack size: 1 g.
Medchemexpress LLC Lei-101 hydrochloride | 2250025-91-1 | 99.4% | 508.99 | C23H26ClFN4O4S | 100MG
LEI-101 is a potent, selective cannabinoid CB2 receptor agonist used for biochemical and pharmacological research. It shows high selectivity for CB2 over CB1, is orally bioavailable, and is supplied as a solid for laboratory studies. Intended for research use only (not for human use).
- Selective CB2 receptor agonist with approximately 100-fold selectivity over CB1.
- Orally bioavailable, suitable for in vivo pharmacology studies.
- High purity (99.35%).
- Molecular weight 508.99 and formula C23H26ClFN4O4S.
- Soluble in DMSO (approx. 116.7 mg/mL).
- Intended for laboratory research use only, not for human consumption.
Medchemexpress LLC Sodium lauroyl glutamate | 29923-31-7 | 95.8% | 100 MG
Sodium lauroyl glutamate is an anionic amino acid surfactant. It has the potential for irritant contact dermatitis and possible anti-irritating potential in a surfactant mixture on human skin. It is primarily used in cleaning products and has been shown to exhibit low irritation to nude mouse skin at 1% w/w for 1 hour. This product is for research use only and not sold to patients.
- Anionic amino acid surfactant.
- Low irritation to nude mouse skin at 1% w/w for 1 hour.
- Primarily used in cleaning products.
- Mild surfactant with a pH value of 5.41.
- For research use only.
Apexbio Technology LLC 1-2-Dilauroyl-sn-glycerol
1 2-Dilauroyl-sn-glycerol (CAS No 60562-15-4) is a synthetic diacylglycerol analog commonly used in biochemical and cellular research to study signal transduction pathways Originating from the glycerolipid family it acts as an activator of protein kinase C (PKC) a key component in various signaling cascades PKC is implicated in cellular processes such as differentiation proliferation and apoptosis This compound exhibits in vitro activity in the nanomolar to low micromolar range facilitating studies on its effects at the molecular level It is often applied in cell models including cultured mammalian cells to investigate cellular responses and in animal studies for its potential therapeutic implications Its consistency in behavior makes it valuable for screening drug candidates targeting PKC pathways Experimental concentrations typically depend on the specific research design allowing for optimization based on the targeted outcomes and biological systems employed
Medchemexpress LLC ULK-101 25mg | 2443816-45-1 | 460.45 | C22H16F4N4OS | 25 MG
ULK-101 is a potent, selective small-molecule inhibitor of ULK1 used in cellular and biochemical research to suppress autophagy and sensitize cancer cells to nutrient stress.
- Potent ULK1 inhibition (IC50 = 1.6 nM) with lower activity on ULK2 (IC50 = 30 nM).
- High purity suitable for research applications (99.91%).
- Available as a powder in multiple pack sizes, including 25 MG, and as DMSO solution formats.
- Storage-stable when kept at recommended temperatures for powder and solutions.
- Molecular weight 460.45 and molecular formula C22H16F4N4OS.
Medchemexpress LLC Sulforhodamine 101 DHPE | 187099-99-6 | >95.0% | 1381.84 | C74H117N4O14PS2 | 1MG
Sulforhodamine 101 DHPE is a red fluorescent phospholipid probe created by conjugating dipalmitoyl phosphoethanolamine to sulforhodamine 101. It readily incorporates into lipid bilayers and is used for membrane imaging, monitoring probe colocalization in liposomes, and detecting protein-ligand interactions on supported bilayers. The dye exhibits excitation/emission peaks near 586/605 nm and is supplied as a powder with recommended cold storage.
Medchemexpress LLC Uk-101 | 1000313-40-5 | 99.6% | 484.74 | C25H48N2O5Si | 10 MG
UK-101 is a potent, selective inhibitor of the immunoproteasome β1i (LMP2) subunit used as a biochemical probe to study immunoproteasome activity and apoptosis-related pathways.
- Potent LMP2 inhibition (IC50 ≈ 104 nM).
- High selectivity versus β1c and β5 subunits.
- High purity suitable for research use (≈99.6%).
- Soluble in DMSO (≈7.3 mg/mL); may require warming or sonication.
- Supplied in small quantities appropriate for laboratory assays.
- Commonly used in biochemical assays and apoptosis research.
Apexbio Technology LLC PKUMDL-LC-101-D04 2143896-83-5 10mg
PKUMDL-LC-101-D04 (CAS 2143896-83-5) is a small molecule allosteric activator of glutathione peroxidase 4 (GPX4) a key enzyme regulating ferroptosis In biochemical and cell extract assays PKUMDL-LC-101-D04 enhances GPX4 activity to 150% of baseline at concentrations of 20 M and 61 M respectively This compound serves as a valuable tool for investigating the modulation of ferroptosis through GPX4 activation and supports research into oxidative stress and cell death mechanisms