Carboxylic acids and derivatives
Medchemexpress LLC Cinepazide maleate | 26328-04-1 | 99.7% | 533.57 g/mol | C26H35N3O9 | 10 MG
Cinepazide maleate is a piperazine-derivative vasodilator and weak calcium channel blocker used in preclinical research into cerebrovascular and cardiovascular disorders. It is supplied as a white to off-white solid of high purity and is intended for in vitro and in vivo studies focused on vascular function and ion-channel modulation.
- Vasodilator and weak calcium channel blocker used in vascular research.
- High purity (99.7%) suitable for reproducible experimental results.
- White to off-white solid for standard laboratory handling.
- Recommended sealed storage away from moisture to maintain stability.
- Supplied in small research quantities for preclinical use.
Selleck Chemical LLC Ciproxifan Maleate S2813-5mg
Ciproxifan (FUB 359) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9 2 nM with low apparent affinity at other receptor subtypes
eMolecules 922-67-8 | Methyl propiolate | Oakwood Chemical | MFCD00008572 | 84.074 | C4H4O2 | 97.000 | COC(=O)C#C | 500g | 536985147
Methyl propiolate | Oakwood Chemical | 922-67-8 | MFCD00008572 | 84.074 | C4H4O2 | 97.000 | COC(=O)C#C | 500g | 536985147
Medchemexpress LLC Asenapine maleate | 85650-56-2 | 99.95% | 401.84 | 50 MG
Asenapine maleate, a brain-penetrant atypical antipsychotic, acts as an antagonist of serotonin receptors, adrenoceptors, dopamine receptors, and histamine receptors. It is used in the research of schizophrenia and bipolar disorder.
- Exhibits high affinity for several serotonin, adrenergic, and dopamine receptors, indicating strong target engagement.
- Acts as a potent antagonist at various serotonin, dopamine, adrenergic, and histamine receptors.
- Demonstrates potential for superior therapeutic effect on anxiety symptoms in animal models.
- Shows anxiolytic-like effects in behavioral tests in mice.
Medchemexpress LLC Avitinib maleate | 1557268-88-8 | 99.9% | 603.60 | 50 MG
Avitinib maleate (Abivertinib maleate) is a third-generation, irreversible and orally active selective EGFR inhibitor. It also functions as a BTK inhibitor that induces apoptosis and inhibits phosphorylation of BTK in mantle cell lymphoma. It demonstrates anticancer effects.
- Third-generation, irreversible, and orally active selective EGFR inhibitor.
- Potent against EGFR L858R, EGFR T790M, and wild-type EGFR.
- BTK inhibitor.
- Induces apoptosis.
- Inhibits phosphorylation of BTK in mantle cell lymphoma.
- Shows anticancer effects.
Medchemexpress LLC VTP50469 fumarate | 2169919-29-1 | 99.8% | 804.93 | 100 MG
VTP50469 fumarate is a potent, highly selective, and orally active Menin-MLL interaction inhibitor. It demonstrates potent anti-leukemia activity with a Ki of 104 pM.
- Inhibits cell proliferation in MLL-r and ALL cell lines
- Induces apoptosis in MLL-r B cell ALL cell lines
- Causes dose-dependent differentiation in MLL-r AML cell lines
- Displaces Menin from protein complexes and inhibits chromatin occupancy of MLL
- Leads to changes in gene expression, differentiation, and apoptosis
- Shows significant survival advantage in in vivo studies in NSG mice
Medchemexpress LLC Dimethyl fumarate-d6 | 66487-95-4 | 99.9% | 150.16 | 1 MG
Dimethyl fumarate-d6 is a deuterium-labeled Dimethyl fumarate that acts as a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator, leading to the upregulation of antioxidant gene expression. It is intended for research use only and can be used for various analytical purposes.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by techniques such as NMR, GC-MS, or LC-MS
Medchemexpress LLC Dizocilpine maleate | 77086-22-7 | 337.37 | 50 MG
Dizocilpine maleate (MK-801 maleate) is a potent, selective, and non-competitive NMDA receptor antagonist with a Kd of 37.2 nM in rat brain membranes. It causes a progressive, long-lasting blockade of current induced by N-Me-D-Asp and can inhibit the activation of microglia induced by LPS. It is also used to induce schizophrenia models.
- Potent, selective, and non-competitive NMDA receptor antagonist
- Binds with NMDA receptor
- Blocks N-Me-D-Asp-activated single-channel activity
- Inhibits activation of microglia induced by LPS
- Can be used to induce schizophrenia models
Medchemexpress LLC Mepyramine maleate (pyrilamine maleate) | 59-33-6 | 99.9% | 1 ML
Mepyramine maleate is a first-generation antihistamine that acts as an antagonist of the histamine H1 receptor. It is characterized by specific binding affinities for H1, H2, and H3 receptors.
- Antagonist of the histamine H1 receptor
- Binds to H1 receptor with Kd of 0.8 nM
- Exhibits Kds of 5200 nM for H2 and >3000 nM for H3 receptors
- Decreases InsP levels in CHO-gpH1 cells
- Reduces maximal response to ATP in CHO-gpH1 cells
- Demonstrates analgesic effects in vivo at specific dosages
Medchemexpress LLC Diethyl maleate | 141-05-9 | MFCD00009191 | 98.7% | 172.18 | C8H12O4 | 100mg
Diethyl maleate (DEM) is an orally available effective glutathione (GSH) depletor that crosses the blood-brain barrier Diethyl maleate covalently binds irreversibly to GSH via glutathione S-transferase with an in vitro IC50 of 0 1-0 5 mM Diethyl maleate selectively depletes GSH in liver lung and brain tissues exacerbating oxidative stress and enhancing hyperbaric oxygen toxicity Diethyl maleate promotes precursor amino acid uptake and in turn promotes GSH synthesis by upregulating the activity of the cystine-glutamate transporter XO- Diethyl maleate can be used to study redox homeostasis and GSH protection mechanisms in oxidative stress-related diseases such as hyperbaric oxygen injury and metabolic diseases[1][2][3]
eMolecules Ambeed Benzyl propiolate 100mg 784395629 A332728 0 000 14447-01-9 MFCD11976128 160 172 C10H8O2
Ambeed Benzyl propiolate 100mg 784395629 A332728 0 000 14447-01-9 MFCD11976128 160 172 C10H8O2