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Organic compounds that contain one or more carbonyl (a carbon atom with a double bond to an oxygen atom) functional groups. Includes compounds with functional groups that contain a carbonyl in their structure such as ketones, aldehydes, and others.
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. CI-1040 (PD 184352) (PD184352) is an ATP non-competitive MEK1/2 inhibitor (IC50 17 nM). purity: 99%
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Tisolagiline methylsulfate is a selective, reversible, and orally active inhibitor for MAO-B with an IC50 of 8 nM. It exhibits neuroprotective and anti-neuroinflammatory activities. This product is for research use only and is not sold to patients.
IC50 & target: MAO-B: 8 nM (IC50)
In vitro: At 1 μM for 4 days, it inhibits astrocyte activation and scar formation by reducing glial fibrillary acidic protein (GFAP) and glycosaminoglycans (CSPGs) expression.
In vivo: In MPTP-induced Parkinson's disease mouse models, it ameliorates motor dysfunction and reduces GFAP/iNOS expression. In U87 MG xenograft models, it inhibits astrocyte scar formation, enhancing Doxorubicin penetration and increasing glioblastoma (GBM) tumor volume.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More