Aminobenzoic acids and derivatives
Medchemexpress LLC KB-R7943 mesylate | 182004-65-5 | C17H21N3O6S2 | 1 ML
KB-R7943 mesylate is an inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with an IC50 of 5.7 ± 2.1 μM. It induces cancer cell death by activating the JNK pathway and blocking autophagic flux.
- Blocks NMDAR-mediated ion currents.
- Inhibits NMDA-induced increase in cytosolic Ca2+ (IC50 = 13.4 ± 3.6 μM).
- Accelerates calcium deregulation and mitochondrial depolarization in glutamate-treated neurons.
- Depolarizes mitochondria in a Ca2+-independent manner.
- Inhibits 2,4-dinitrophenol-stimulated respiration (IC50 = 11.4 ± 2.4 μM).
- Dose-dependently and reversibly blocks ion currents elicited by NMDA.
- Inhibits ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels.
- Inhibits both IhERG and native IKr (IC50 values of ~89 nM and ~120 nM, respectively).
Medchemexpress LLC Tetrindole mesylate | 170964-68-8 | 99.9% | 390.54 | C21H30N2O3S | 1 MG
Tetrindole mesylate is a research reagent that acts as a selective monoamine oxidase A (MAO A) inhibitor used in biochemical and pharmacological investigations of MAO-A activity and antidepressant mechanisms. It is supplied as a solid mesylate salt with high purity and is intended for laboratory research use only. Recommended storage: -20°C sealed and away from moisture; in solvent: -80°C (up to 6 months) or -20°C (up to 1 month).
- Selective MAO-A inhibitory activity for mechanistic and pharmacology studies.
- High purity (99.93%) suitable for analytical and preclinical assays.
- Solid form for accurate weighing and formulation.
- Contains CAS number 170964-68-8 for unambiguous identification.
- Recommended cold storage to preserve stability.
Medchemexpress LLC Cep-28122 (mesylate salt) | 2070009-30-0 | 99.9% | 635.17 | 1 ML
CEP-28122 mesylate salt, a diaminopyrimidine derivative, is a potent, selective, and orally active ALK inhibitor with an IC50 value of 1.9 nM. It exhibits antitumor activity in experimental models of ALK-positive human cancers and possesses good pharmacodynamic and pharmacokinetic activity. This product can be utilized for the study of ALK-positive anaplastic large-cell lymphoma (ALCL), non-small cell lung cancer (NSCLC), and neuroblastoma cells.
- Potent, selective, and orally active ALK inhibitor with an IC50 value of 1.9 nM.
- Exhibits antitumor activity in experimental models of ALK-positive human cancers.
- Possesses good pharmacodynamic and pharmacokinetic activity.
- Can be used for the study of ALK-positive anaplastic large-cell lymphoma (ALCL), non-small cell lung cancer (NSCLC), and neuroblastoma cells.
Medchemexpress LLC Pridinol mesylate | 6856-31-1 | MFCD00079241 | 99.97% | 50 MG
Pridinol mesylate is an orally active, blood-brain permeable muscle relaxant, targeting muscarinic acetylcholine receptors. It reduces impulses to spinal motor neurons, inhibiting skeletal muscle contractures of central and peripheral origin.
- Muscarinic acetylcholine receptor-directed muscle relaxant
- Reduces conduction of impulses to spinal motor neurons
- Inhibits skeletal muscle contractures
- Used in research for musculoskeletal diseases
Medchemexpress LLC PF-04217903 mesylate | 956906-93-7 | 99.8% | 1 ML
PF-04217903 mesylate is the methanesulfonate salt of a potent ATP-competitive c-Met (HGFR) kinase inhibitor supplied as a high-purity research compound for biochemical and cell-based studies.
- Potent ATP-competitive c-Met kinase inhibitor (Ki = 4.8 nM).
- High purity, 99.82%.
- Molecular weight 468.49 and formula C20H20N8O4S.
- Available as 10 mM solution in DMSO, 1 mL, and as solids in multiple masses.
- Suitable for in vitro biochemical and cellular assays.
![eMolecules 169869-90-3 | Exatecan mesylate | Ambeed | MFCD04113012 | 531.560 | C25H26FN3O7S | 98.000 | CS(O)(=O)=O.CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc(F)c(C)c5CC[C@H](N)c(c3Cn1c2=O)c45 | 1g | 784396078](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000216525.jpg-250.jpg)
eMolecules 169869-90-3 | Exatecan mesylate | Ambeed | MFCD04113012 | 531.560 | C25H26FN3O7S | 98.000 | CS(O)(=O)=O.CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc(F)c(C)c5CC[C@H](N)c(c3Cn1c2=O)c45 | 1g | 784396078
Exatecan mesylate | Ambeed | 169869-90-3 | MFCD04113012 | 531.560 | C25H26FN3O7S | 98.000 | CS(O)(=O)=O.CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc(F)c(C)c5CC[C@H](N)c(c3Cn1c2=O)c45 | 1g | 784396078
Medchemexpress LLC Larotinib mesylate hydrate | 2097129-93-4 | C26H36ClFN4O11S2 | 100 MG
Larotinib mesylate hydrate is a potent, broad-spectrum, and orally active tyrosine kinase inhibitor (TKI) with EGFR as the main target with an IC50 of 0.6 nM. This compound is intended for research use only.
- Inhibits EGFRL861Q (IC50: 0.423 nM)
- Inhibits EGFRL858R (IC50: 0.563 nM)
- Inhibits EGFR (WT) (IC50: 0.611 nM)
- Inhibits EGFRT790M (IC50: 45.2 nM)
- Inhibits HER4 (IC50: 84 nM)
- Inhibits BLK (IC50: 102 nM)
- Inhibits IRAK-1 (IC50: 167 nM)
- Inhibits BTK (IC50: 196 nM)
- Inhibits HER2 (IC50: 253 nM)
Medchemexpress LLC DOTAP mesylate 25mg
DOTAP mesylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research
eMolecules 138-14-7 | Deferoxamine Mesylate | Ambeed | MFCD00058605 | 656.790 | C26H52N6O11S | 98.000 | CS(O)(=O)=O.CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN | 1g | 600851355
Deferoxamine Mesylate | Ambeed | 138-14-7 | MFCD00058605 | 656.790 | C26H52N6O11S | 98.000 | CS(O)(=O)=O.CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN | 1g | 600851355
Medchemexpress LLC Pritelivir (mesylate hydrate) | 1428321-10-1 | C19H24N4O7S3 | 25 MG
Pritelivir (mesylate hydrate) | 1428321-10-1 | C19H24N4O7S3 | 25 MG
Medchemexpress LLC Obatoclax mesylate | 803712-79-0 | 99.9% | 413.49 | 1 ML
Obatoclax Mesylate is a BH3 mimetic and a pan-BCL-2 family proteins inhibitor that induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. It exhibits anti-cancer and broad-spectrum antiparasitic activity.
- Inhibits BCL-2 family proteins including BCL-2, BCL-XL, MCL-1, BCL-w, A1, and BCL-b
- Induces autophagy-dependent cell death
- Targets cyclin D1 for proteasomal degradation
- Demonstrates anti-cancer and broad-spectrum antiparasitic activity
- Reduces cell numbers in human colorectal cancer cell lines (HCT116, HT-29, LoVo)
- Increases G1-phase cell populations
- Causes a marked drop in cyclin D1 levels, inhibits GSK3β, and activates p38MAPK
- Shows potent antitumor activity in xenograft mouse models
Apexbio Technology LLC KB-R7943 mesylate 182004-65-5 50mg
KB-R7943 mesylate (CAS 182004-65-5) is a selective inhibitor of the Na /Ca2 exchanger (NCX) particularly effective against its reverse mode It inhibits NCX-mediated Ca2 influx with an IC50 of 0 7 M In transfected Chinese hamster ovary (CHO) cells expressing NCX KB-R7943 suppresses exchanger activity at high intracellular Na concentrations In cultured rat forebrain neurons it attenuates Ca2 transients induced by glutamate NMDA kainate or KCl with IC50 values ranging from 2 9 to 8 2 M In in vivo studies KB-R7943 reduces endothelin-1 levels and mitigates acute renal dysfunction following ischemic injury This compound is widely utilized in studies investigating Na /Ca2 exchange and related calcium signaling pathways
Apexbio Technology LLC Nafamostat 81525-10-2 10mg
Nafamostat (CAS 81525-10-2) is a small-molecule inhibitor targeting a broad spectrum of serine proteases including thrombin plasmin kallikrein and human trypsin It is designed to block protease-mediated hydrolysis reactions thereby regulating coagulation pathways and inflammation-related protease activity Nafamostat exerts its biological activity primarily through reversible binding to protease active sites inhibiting their enzymatic functions In biochemical assays Nafamostat demonstrates potent inhibitory activity with an IC50 value of approximately 1 10 nM against human trypsin Based on these pharmacological properties Nafamostat holds research potential in coagulation pathway studies inflammation-related protease research pancreatitis modeling and mechanistic investigations of blood coagulation disorders and inflammatory responses
Medchemexpress LLC 4(5H)-thiazolone, 2-amino-5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene] methanesulfonate | 139340-56-0 | MFCD00906463 | 99.7% | 428.57 g·mol⁻¹ | C19H28N2O5S2 | 10 MG
Darbufelone mesylate is a research-grade small molecule inhibitor that suppresses prostaglandin F2α and leukotriene B4 production by preferential inhibition of cyclooxygenase-2 (COX-2). Supplied as the mesylate salt for improved handling, it is intended for in vitro and in vivo research applications and is available as a solid or as a DMSO solution.
- Potent COX-2 inhibition (IC50 ≈ 0.19 μM)
- Dual inhibition of PGF2α and LTB4 production
- High purity suitable for research (≈99.7%)
- Soluble in DMSO (≈110 mg/mL), practically insoluble in water
- Available as 10 mg solid or 10 mM solution in DMSO
- Recommended storage sealed, away from moisture and light
Medchemexpress LLC Reboxetine mesylate | 98769-84-7 | 99.7% | C20H27NO6S | 50 MG
Reboxetine mesylate is a potent, selective, and specific noradrenaline reuptake inhibitor (NARI) primarily used for depression research. It effectively inhibits norepinephrine uptake with a Ki of 8 nM.
- Weak affinity for muscarinic, histaminergic H1, adrenergic α1, and dopaminergic D2 receptors.
- Prevents dexamethasone-induced decreases in cell viability and proliferation rate in SH-SY5Y cells (0.1 μM, 1 μM, 5 μM for 24 hours).
- Significantly decreases immobility time in mice depression models (30 mg/kg; i.p.).