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Organic compounds that consist of a phenol ring with a ciclohexane substitution; includes compounds in which the ciclohexane group has additional substitutions.
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NU9056 is a potent and selective Tip60 (KAT5) histone acetyltransferase inhibitor with an IC50 of 2 μM. It demonstrates over 16-fold selectivity for Tip60 compared to PCAF, p300, and GCN5. This compound is known to induce apoptosis in prostate cancer cells.
Activates caspase 3 and caspase 9 in a time- and concentration-dependent manner.
Decreases acetylated histone H4K16, H3K14, and H4K8 levels.
Reduces androgen receptor, prostate-specific antigen, p53, and p21 protein levels.
Induces apoptosis in LNCaP cells.
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EW-7195 is a potent, selective ALK5 (TGFβR1) inhibitor for research use that blocks TGF-β1-induced Smad signaling, epithelial-to-mesenchymal transition, and metastatic progression in preclinical studies. It provides low-nanomolar potency and is supplied with high purity for laboratory assays.
Potent ALK5 inhibition with low-nanomolar IC50.
High selectivity over related kinases, >300-fold versus p38α.
Blocks TGF-β1-induced Smad signaling and epithelial-to-mesenchymal transition.
Demonstrated anti-metastasis activity in preclinical models.
High purity suitable for research applications.
Soluble in DMSO for assay preparation.
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Medchemexpress,HY-B0216 500mg Ethynyl Estradiol 17α-Ethynylestradiol;Ethynylestradiol CAS:57-63-6 Formula:C20H24O2 Purity:98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
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Effusol is a natural phenolic constituent isolated from Juncus effusus with potent radical-scavenging antioxidant activity and reported neuroprotective effects. Supplied as a research-grade solid, the manufacturer provides solubility guidance and storage recommendations for experimental use.
Natural phenolic constituent from Juncus effusus.
Potent antioxidant activity against DPPH and ABTS radicals.
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AAPK-25 is a potent, selective dual inhibitor of Aurora kinases and Polo-like kinases (PLK) used in preclinical research to investigate cell cycle regulation and anticancer mechanisms. It causes mitotic delay and arrests cells in prometaphase, and is provided as a solid or as a DMSO solution for cellular and biochemical assays.
Potent dual inhibitor of Aurora kinases and PLK.
Induces mitotic delay and prometaphase arrest in cells.
Suitable for cellular and biochemical kinase assays.
High purity (98.1%) for research applications.
Available in solid and solution formats for flexible use.
Simple storage guidance for sample stability in solution and solid forms.
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DS45500853 is a small-molecule agonist of estrogen-related receptor α (ERRα) supplied as a high-purity solid for research use. It is characterized by formula C18H20O3 and molecular weight 284.35 g·mol-1, and is intended for biochemical and cell-based assays targeting ERRα.
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Prudomestin is a flavonoid isolated from the heartwood of Prunus domestica that exhibits potent xanthine oxidase (XO) inhibitory activity (IC50 ≈ 6 μM). It is supplied as a light yellow to yellow solid for research use and should be protected from light during storage.
Potent xanthine oxidase inhibitor (IC50 ≈ 6 μM).
Molecular formula C17H14O7.
Molecular weight 330.29 g/mol.
CAS number 3443-28-5.
Purity 98.4%.
Appearance light yellow to yellow solid.
Storage recommendations: 4°C, protect from light; in solvent: -80°C (6 months), -20°C (1 month).
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
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Estradiol-d4 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. It upregulates IL-6 expression through the estrogen receptor beta (ERβ) pathway.
Used as a tracer
Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Incorporates stable heavy isotopes of hydrogen, carbon, and other elements
Deuteration affects the pharmacokinetic and metabolic profiles of drugs
Applicable in cancer research, metabolic or endocrine disease, and endocrinology
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Parishin is a phenolic glucoside isolated from Gastrodia elata that exhibits anti-aging activity in yeast via modulation of the Sir2/Uth1/TOR signaling pathway. It is supplied as a high-purity solid with recommended solvent formulations and storage conditions for research applications.
High purity (98.92%)
Off-white to light yellow solid
Available as solid and as 10 mM DMSO solution for in vitro use