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Filtered Search Results
Accela Chembio Inc 2-fluoro-5-methylbenzonitrile | 100g | 64113-84-4 | MFCD00134542 | 97+% | Shelf Life: 1260 Days | Regular
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2-fluoro-5-methylbenzonitrile | 100g | 64113-84-4 | MFCD00134542 | 97+% | Shelf Life: 1260 Days | Regular
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eMolecules 1110813-31-4 | Medchem Express | Dacomitinib | 5mg | 446262638 | HY-13272 | MFCD19443734 | 469.95 | C24H25ClFN5O2
Ambeed | 4-trans-(((S)-5-((35-Bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-79-dimethyl-2345-tetrahydro-1H-benzo[b]azepin-1-yl)methyl)cyclohexanecarboxylic acid | 1mg | 552695946 | A293328 | 1186486-62-3 | MFCD23105886 | 638.659 | C31H36F6N6O2
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Medchemexpress LLC Hexanamide, 2-(acetylamino)-6-amino-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-, (2S)- | 156661-42-6 | 98.9% | 345.39 g/mol | C18H23N3O4 | 5 MG
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Ac-Lys-AMC (Hexanamide), also termed MAL, is a fluorogenic substrate used to measure histone deacetylase (HDAC) activity. After HDAC-catalyzed deacetylation and subsequent enzymatic cleavage, the 7-amido-4-methylcoumarin (AMC) moiety is released, producing a fluorescent signal for quantitative biochemical assays and inhibitor screening. Supplied as a solid for research use only.
- Fluorogenic substrate for HDAC activity assays.
- Enables sensitive fluorescence detection via AMC release.
- High purity (HPLC) for reliable assay results.
- Solid, white to off-white physical form for easy storage and handling.
- Intended for research use only; not for human or clinical use.
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Medchemexpress LLC Tolinapant | 1799328-86-1 | 99.81% | 539.68 | 10 MG
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Tolinapant is an orally bioavailable dual antagonist of cellular inhibitor of apoptosis protein (cIAP) and X-linked inhibitor of apoptosis protein (XIAP). It is for research use only.
- Being investigated in a single-agent Phase 1/2 clinical trial for advanced solid tumors and lymphomas.
- Demonstrated sensitivity in 43% of cell lines treated in vitro.
- Induces moderate tumor growth inhibition in HCC1806 xenografts in mice with daily oral treatment.
- High solubility: 100 mg/mL (185.29 mM) in DMSO.
- Solubility in mixed solvents is ≥ 2.5 mg/mL (4.63 mM), forming clear solutions.
- Stable for extended periods: 3 years as powder at -20°C, 2 years as powder at 4°C, 2 years in solvent at -80°C, and 1 year in solvent at -20°C.
- Targets IAP and Apoptosis pathways.
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Medchemexpress LLC HY-12532 5mg Medchemexpress, Astemizole CAS:68844-77-9 Purity:>98%
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Medchemexpress, HY-12532 5mg Astemizole CAS:68844-77-9 Astemizole (R 43512), a second-generation antihistamine drug to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC 50 of 4 nM. Astemizole also shows potent hERG K + channel blocking activity with an IC 50 of 0.9 nM. Astemizole has antipruritic effects [1] [2] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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eMolecules 85734-19-6 | 4-FLUOROANILINE HYDROIODIDE | AstaTech239.032 | C6H7FIN | 95.000 | I.Nc1ccc(F)cc1 | 1g | 722710326
4-FLUOROANILINE HYDROIODIDE | AstaTech | 85734-19-6239.032 | C6H7FIN | 95.000 | I.Nc1ccc(F)cc1 | 1g | 722710326
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eMolecules 2304549-73-1 | Medchem Express | GFB-8438 | 5mg | 532149276 | HY-133012 | 386.76 | C16H14ClF3N4O2
Ambeed | Methyl 2-chloro-3-nitrobenzoate | 250mg | 552602778 | A161787 | 53553-14-3 | MFCD00482383 | 215.590 | C8H6ClNO4
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eMolecules 350682-84-7 | 4-BIPHENYL-3',5'-DIFLUORO-CARBOXYLIC ACID | AstaTech | MFCD03839971 | 234.202 | C13H8F2O2 | 97.000 | OC(=O)c1ccc(cc1)-c1cc(F)cc(F)c1 | 0.25g | 112530510
4-BIPHENYL-3',5'-DIFLUORO-CARBOXYLIC ACID | AstaTech | 350682-84-7 | MFCD03839971 | 234.202 | C13H8F2O2 | 97.000 | OC(=O)c1ccc(cc1)-c1cc(F)cc(F)c1 | 0.25g | 112530510
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eMolecules 2248003-60-1 | Medchem Express | AZD3229 | 5mg | 441681885 | HY-112802 | 479.516 | C24H26FN7O3
Ambeed | 25-Dimethylaniline hydrochloride | 1g | 666598484 | A484131 | 51786-53-9 | MFCD00054333 | 157.640 | C8H12ClN
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Medchemexpress LLC αvβ1 integrin-IN-1 TFA | 1689540-62-2 | MFCD30747846 | 98.3% | 672.67 g·mol⁻¹ | C28H35F3N6O8S | 10 MG
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αvβ1 integrin-IN-1 TFA (Compound C8) is a potent, selective small-molecule inhibitor of αvβ1 integrin for research use. It has an IC50 of 0.63 nM and demonstrates antifibrotic effects in mouse models of liver and lung fibrosis. Supplied as a white to off-white solid and as DMSO solutions, it is provided with high purity for biochemical and cellular assays.
- Potent αvβ1 inhibition with IC50 0.63 nM.
- High purity (≈98.3%) suitable for research assays.
- Molecular weight 672.67 g·mol⁻¹.
- White to off-white solid; available as DMSO solution concentrates.
- Used to study fibrotic pathways in liver and lung models.
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Medchemexpress LLC STING Agonist-12 | 2259624-71-8 | 98.3% | 490.88 | 50 MG
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STING agonist-12 is a potent, orally active human STING activator with an EC50 of 185 nM. It demonstrates excellent pan-polymorph activity across STING proteins in HEK293T cells. This compound is well-absorbed in animal models, exhibiting a short terminal half-life. For research use only.
- Potent, orally active human STING activator
- EC50 of 185 nM against STING
- Excellent pan-polymorph activity
- Not active at mouse STING
- Well-absorbed in animal models
- Short terminal half-life
- Appearance: Solid, light yellow to yellow
- Shipping: Room temperature (continental US)
- Storage: 4°C, protect from light (solid)
- Storage in solvent: -80°C for 6 months; -20°C for 1 month (protect from light)
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Medchemexpress LLC 5-(3-bromophenyl)-1,3-dihydro-benzofuro[3,2-e]diazepin-2-one | 768404-03-1 | MFCD18086878 | 99.9% | 355.19 | C17H11BrN2O2 | 10 MG
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5-BDBD is a potent, selective P2X4 receptor antagonist used for in vitro pharmacology and cellular research. It inhibits rP2X4R-mediated currents (IC50 ~0.75 μM) and is provided as a high-purity solid suitable for preparing DMSO stock solutions and conducting receptor assays.
- Potent P2X4 receptor antagonist with reported IC50 ~0.75 μM.
- High purity (≈99.9%).
- Molecular formula C17H11BrN2O2; molecular weight 355.19 g/mol.
- Solid, white to light yellow, appropriate for dissolution and storage.
- Soluble in DMSO at 62.5 mg/mL; may require sonication and heating to 60°C.
- Recommended storage: powder at -20°C for long term; solutions at -80°C for short term.
- Supplied in small research-scale quantities for laboratory experiments.
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Medchemexpress LLC α-Spinasterol | 481-18-5 | MFCD00200554 | 5 MG
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α-Spinasterol is an orally taken antagonist of transient receptor potential vanilloid 1 (TRPV1), and it is also an inhibitor of COX-1 and COX-2, with IC50 values of 16.17 μM and 7.76 μM, respectively. It exhibits antibacterial, anti-inflammatory, antidepressant, and antioxidant effects, has the ability to cross the blood-brain barrier, and can improve diabetes in mice.
- Antagonist of transient receptor potential vanilloid 1 (TRPV1)
- Inhibitor of COX-1 and COX-2
- Exhibits antibacterial, anti-inflammatory, antidepressant, and antioxidant effects
- Ability to cross the blood-brain barrier
- Can improve diabetes in mice
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Medchemexpress LLC Spadin TFA | 99.7% | 2126.36 | 5 MG
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Spadin TFA is a natural peptide derived from a propeptide found in blood. It is a potent TREK-1 channel blocker with an IC50 value of 10 nM. This peptide enhances dorsal raphe nucleus 5-HT neurotransmission in mice and promotes hippocampal CREB activation and neurogenesis. It is used in antidepressant research.
- Potent TREK-1 channel blocker (IC50 value of 10 nM)
- Enhances dorsal raphe nucleus 5-HT neurotransmission in mice
- Induces hippocampal CREB activation and neurogenesis
- Inhibits TREK-1 channel and blocks 63% of TREK-1 current stimulated by arachidonic acid in COS-7 cells (100 nM)
- Blocks TREK-1 channel activity in CA3 hippocampal neurons on brain slices of wild-type mice (100 nM)
- Increases 5-HT neuron firing rate in the dorsal raphe nucleus (DRN) in male C57Bl/6J and TREK-1 deficient mice
- Shows anti-depressant behavior in mice
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Medchemexpress LLC HY-128350A 5mg Medchemexpress, FGTI-2734 (mesylate) CAS: Purity:>98%
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Medchemexpress, HY-128350A 5mg FGTI-2734 (mesylate) CAS: FGTI-2734 mesylate is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT, respectively. FGTI-2734 mesylate can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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