Phthalic acid and derivatives
Medchemexpress LLC Terephthalic acid | 100-21-0 | 99.99% | 166.13 | 50 G
Terephthalic acid is an isomer and a precursor of polyester PET, used in clothing and plastics. It can also be utilized to build skin tumor models and promote excessive cell proliferation by disrupting the p16-cyclin D1/Cdk4-Rb cell cycle regulatory pathway. In vivo, it can lead to bladder stone formation in animal models, particularly in weanling mice at higher doses.
- Isomer and precursor of polyester PET
- Used to build skin tumor models
- Promotes excessive cell proliferation
- Induces skin tumor formation
- Metabolized to form calcium terephthalate, potentially leading to bladder stone formation
Medchemexpress LLC Disodium 5'-inosinate | 4691-65-0 | 99.7% | 10 G
Disodium 5'-inosinate is a nucleotide-based umami agent. It binds to umami receptors and stimulates taste nerves, leading to the perception of umami. Additionally, it has been observed to produce transient behavioral excitement in mice.
- Nucleotide-based umami agent
- Binds to umami receptors and stimulates taste nerves
- Produces transient behavioral excitement in mice
Medchemexpress LLC Terephthalic acid | 100-21-0 | 99.99% | 166.13 | 100 MG
Terephthalic acid is an isomer and precursor of polyester PET, widely used in textiles and plastics. It is also utilized in biological research for developing skin tumor models. This compound promotes cell proliferation and can induce skin tumor formation by interfering with the p16-cyclin D1/Cdk4-Rb cell cycle regulatory pathway.
- Isomer and precursor of polyester PET
- Used in clothing and plastics
- Can be used to build skin tumor models
- Promotes excessive cell proliferation
- Induces skin tumor formation
- May lead to bladder stone formation at higher doses
Medchemexpress LLC Calcium disodium edetate hydrate | 23411-34-9 | MFCD00148919 | 98.0% | 374.27 g·mol⁻¹ | C10H12CaN2O8.xH2O.2Na | 10 G
Calcium disodium edetate hydrate is a research-grade chelating reagent used to bind divalent metal ions in biochemical and toxicology studies. Supplied as a solid, it is commonly used for metal-chelation experiments, sample stabilization, and preparation of buffer solutions in life science research.
- High purity (98.0%) suitable for research applications.
- Solid form for easy weighing and accurate dosing.
- Effective chelation of divalent metal ions such as lead and cadmium.
- Compatible with aqueous buffers and typical laboratory solvents.
- Store sealed, away from moisture and light; in solution: -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Terephthalic acid | 100-21-0 | 99.99% | 166.13 | 25 MG
Terephthalic acid is an isomer and a precursor of polyester PET, which can be used to make clothing and plastics. It can also be used to build skin tumor models.
- Isomer and precursor of polyester PET.
- Can be used to build skin tumor models.
- Can promote excessive cell proliferation and induce skin tumor formation by disrupting the p16-cyclin D1/Cdk4-Rb cell cycle regulatory pathway.
- In animal modeling, it can create skin tumor models.
- Metabolized in the body to form calcium terephthalate or calcium hydrogen terephthalate, leading to oversaturation in the urine and promoting the formation of bladder stones.
Apexbio Technology LLC Disodium (R)-2-Hydroxyglutarate 103404-90-6 10mM (in 1mL H2O)
Disodium (R)-2-Hydroxyglutarate (CAS 103404-90-6) is an enantiomer of 2-hydroxyglutarate that functions as an inhibitor of ATP synthase a rotary enzyme complex critical for ATP production via oxidative phosphorylation Studies have shown that (R)-2-hydroxyglutarate accumulates in human cancers harboring IDH1 or IDH2 mutations where it suppresses ATP synthase activity leading to tumor cell growth arrest and cell death particularly under glucose-limited conditions In IDH-mutant glioma cells elevated (R)-2-hydroxyglutarate levels reduce oxygen consumption linked to ATP synthase This molecule is used to investigate metabolic vulnerabilities in malignancies with altered 2-hydroxyglutarate metabolism and the role of ATP synthase in cancer cell survival
Apexbio Technology LLC Disodium (R)-2-Hydroxyglutarate 103404-90-6 100mg
Disodium (R)-2-Hydroxyglutarate (CAS 103404-90-6) is an enantiomer of 2-hydroxyglutarate that functions as an inhibitor of ATP synthase a rotary enzyme complex critical for ATP production via oxidative phosphorylation Studies have shown that (R)-2-hydroxyglutarate accumulates in human cancers harboring IDH1 or IDH2 mutations where it suppresses ATP synthase activity leading to tumor cell growth arrest and cell death particularly under glucose-limited conditions In IDH-mutant glioma cells elevated (R)-2-hydroxyglutarate levels reduce oxygen consumption linked to ATP synthase This molecule is used to investigate metabolic vulnerabilities in malignancies with altered 2-hydroxyglutarate metabolism and the role of ATP synthase in cancer cell survival
Apexbio Technology LLC Disodium (R)-2-Hydroxyglutarate 103404-90-6 25mg
Disodium (R)-2-Hydroxyglutarate (CAS 103404-90-6) is an enantiomer of 2-hydroxyglutarate that functions as an inhibitor of ATP synthase a rotary enzyme complex critical for ATP production via oxidative phosphorylation Studies have shown that (R)-2-hydroxyglutarate accumulates in human cancers harboring IDH1 or IDH2 mutations where it suppresses ATP synthase activity leading to tumor cell growth arrest and cell death particularly under glucose-limited conditions In IDH-mutant glioma cells elevated (R)-2-hydroxyglutarate levels reduce oxygen consumption linked to ATP synthase This molecule is used to investigate metabolic vulnerabilities in malignancies with altered 2-hydroxyglutarate metabolism and the role of ATP synthase in cancer cell survival
Medchemexpress LLC Sulbenicillin disodium | 28002-18-8 | 50 MG
Sulbenicillin disodium is the disodium salt of Sulbenicillin. Sulbenicillin is a Penicillin antibiotic that exhibits antibacterial activity against various mucoid and non-mucoid strains of Pseudomonas aeruginosa.
- Purity: 98.84%
- Molecular Weight: 458.42
- Formula: C16H16N2Na2O7S2
- Appearance: Solid
- Color: White to off-white
- Storage: 4°C, sealed storage, away from moisture
- In-solvent storage: -80°C for 6 months or -20°C for 1 month, sealed and away from moisture
- Solubility in H2O: 250 mg/mL (requires sonication)
- Solubility in PBS: 100 mg/mL (clear solution; requires sonication)
Medchemexpress LLC 1,4-Benzenedicarboxylic acid | 100-21-0 | 99.9% | 166.13 | 10 G
Terephthalic acid is an isomer and a precursor of polyester PET, which can be used to make clothing and plastics. It can also be utilized to build skin tumor models.
- Can be used in animal modeling to create skin tumor models.
- It is metabolized in the body to form calcium terephthalate or calcium hydrogen terephthalate, which can lead to bladder stone formation.
- The lithogenic effect is more pronounced in weanling mice at higher doses.
- Promotes excessive cell proliferation and induces skin tumor formation by disrupting the p16-cyclin D1/Cdk4-Rb cell cycle regulatory pathway.
- Specific modeling methods for skin tumor induction involve topical application in C57BL/6 mice.
![Medchemexpress LLC Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-, 1-(dihydrogen phosphate), sodium salt (1:2) | 168555-66-6 | 99.55% | 440.29 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000386671-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-, 1-(dihydrogen phosphate), sodium salt (1:2) | 168555-66-6 | 99.55% | 440.29 | 1 ML
Fosbretabulin disodium is a tubulin destabilizing agent and a Combretastatin A4 proagent. It selectively targets endothelial cells, leading to the regression of nascent tumor neovessels, reduced tumor blood flow, and central tumor necrosis. This compound has demonstrated inhibitory effects on the growth of various cancer cell lines and increases mean arterial blood pressure while decreasing tumor blood flow in vivo.
- Tubulin destabilizing agent
- Combretastatin A4 proagent
- Selectively targets endothelial cells
- Induces regression of nascent tumor neovessels
- Reduces tumor blood flow
- Causes central tumor necrosis
- Inhibits growth of leukemia P-388, pancreas BXPC-3, neuroblast SK-N-SH, thyroid SW1736, lung-NSC NCI-H460, prostate DU-145, and pharynx FADU
- Increases mean arterial blood pressure in vivo
- Decreases tumor blood flow in vivo