Styrenes
Medchemexpress LLC CFTR(inh)-172 | 307510-92-5 | 99.8% | 409.40 | 1 MG
CFTR(inh)-172 is a potent and selective blocker of the CFTR chloride channel. It reversibly inhibits CFTR short-circuit current in less than 2 minutes with a Ki of 300 nM. The inhibition is complete in approximately 10 minutes (t1/2=4 minutes) and is reversed after washout with a t1/2 of approximately 5 minutes. It is nontoxic to FRT cells after 24 hours at concentrations up to 100 μM. It reduces open probability by > 90% and significantly reduces cholera toxin-induced fluid secretion in mouse models.
- Potent and selective blocker of the CFTR chloride channel.
- Reversibly inhibits CFTR short-circuit current.
- Nontoxic to FRT cells at concentrations up to 100 μM.
- Reduces open probability of CFTR by > 90%.
- Reduces cholera toxin-induced fluid secretion in mouse models.
eMolecules 2,4-Diamino-6-dimethylamino-1,3,5-triazine | 1985-46-2 | MFCD00191338 | 25g
Combi-Blocks, Inc. | 2,4-Diamino-6-dimethylamino-1,3,5-triazine | 25g | 569292747 | QF-9996 | 95.000 | 1985-46-2 | MFCD00191338 | 154.177 | C5H10N6
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Medchemexpress LLC Styrene-divinylbenzene sulfonated copolymer | 69011-20-7 | 98% | 100 G
Styrene-divinylbenzene sulfonated copolymer is a strongly acidic resin and a cationic exchange resin. It is made from a microporous styrene/divinylbenzene (DVB) co-polymer with a sulfonic acid group. This copolymer is suitable for laboratory and research applications.
- Strongly acidic resin
- Cationic exchange resin
- Made from a microporous styrene/divinylbenzene (DVB) co-polymer
- Contains a sulfonic acid group
- For research use only
Medchemexpress LLC Protein kinase G inhibitor-1 | 354544-70-0 | 98.0% | C14H18N2O2S | 1 MG
Protein kinase G inhibitor-1 (Compound 270) is a mycobacterial protein kinase G inhibitor, with an IC50 of 0.9 μM. It can be used for mycobacterial infection research.
- Chemical formula: C14H18N2O2S
- CAS number: 354544-70-0
- Purity: 98.0%
eMolecules 4-Bromo-3-chlorostyrene | 1692077-74-9 | MFCD30237713 | 1g
Apollo Scientific | 4-Bromo-3-chlorostyrene | 1g | 562459079 | OR400918 | 95.000 | 1692077-74-9 | MFCD30237713 | 217.490 | C8H6BrCl
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Medchemexpress LLC K858 racemic | 72926-24-0 | MFCD00181155 | 99.8% | 277.35 g·mol⁻1 | C13H15N3O2S | 10 MG
K858 (racemic) is a small-molecule ATP-uncompetitive inhibitor of the mitotic kinesin Eg5 with an IC50 of 1.3 μM. Supplied as a solid powder, it is intended for cellular and biochemical research into mitosis, spindle dynamics, and antiproliferative mechanisms. Manufacturer guidance includes solubility and in vivo formulation protocols for experimental use.
- ATP-uncompetitive inhibitor of kinesin Eg5 (IC50 1.3 μM).
- High purity (99.8%).
- Solid powder form suitable for laboratory handling.
- Soluble in DMSO up to 100 mg/mL; ultrasonic assistance recommended.
- Includes in vivo formulation protocols for dosing studies.
- Available in small research quantities for preclinical experiments.
eMolecules trans-1-Decalone | 21370-71-8 | MFCD00064175 | 100mg
Oakwood Chemical | trans-1-Decalone | 100mg | 537719759 | 245835 | | 21370-71-8 | MFCD00064175 | 152.237 | C10H16O
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Medchemexpress LLC K858 (Racemic) | 72926-24-0 | 99.8% | 277.34 | 25 MG
K858 Racemic is an ATP-uncompetitive inhibitor of kinesin Eg5 with an IC50 of 1.3 μM.
- Does not inhibit the ATPase activity of the mitotic kinesins CENP-E and MKLP1, or the conventional kinesin heavy chain even at 200 μM.
- Induces mitotic arrest and growth inhibition via the activation of the Mad2-mediated spindle checkpoint.
- Induces mitotic cell death in cancer cells but not in normal cells (at 5 μM).
- Shows antitumor activity in an A2780 ovarian cancer xenograft model, and also inhibits tumor growth in a HCT116 colon cancer xenograft model.
- Displays no neurotoxic side effects in mice (at 100 mg/kg, p.o., qd x5).
Selleck Chemical LLC CPI-637
CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor with IC50 values of 0 03 M and 0 051 M for CBP and EP300 respectively in TR-FRET assay It is highly selective against other bromodomains displaying substantial biochemical activity only against BRD9
Selleck Chemical LLC NMS-873
NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases Hsp90 and 53 additional analyzed kinases (IC50s 10 M)
Selleck Chemical LLC NMS-873
NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases Hsp90 and 53 additional analyzed kinases (IC50s 10 M)