Aminophenols
Medchemexpress LLC SM-433 hydrochloride | 98.6% | 598.18 | 1 ML
SM-433 hydrochloride is a Smac mimetic that functions as an inhibitor of inhibitor of apoptosis proteins (IAPs). It demonstrates strong binding affinity for the XIAP BIR3 protein with an IC50 of less than 1 μM. It also shows potent inhibitory activity against MDA-MB-2131 human breast cancer cells and SK-OV-3 ovarian cancer cells with IC50s less than 10 μM.
- Functions as an inhibitor of apoptosis proteins (IAPs)
- Demonstrates strong binding affinity for the XIAP BIR3 protein with an IC50 of less than 1 μM
- Shows potent inhibitory activity against MDA-MB-2131 human breast cancer cells
- Shows potent inhibitory activity against SK-OV-3 ovarian cancer cells with IC50s less than 10 μM
Medchemexpress LLC LYN-1604 hydrochloride | 2216753-86-3 | MFCD31630830 | >=98.0% | 621.08 | C33H44Cl3N3O2 | 1 MG
A small-molecule hydrochloride salt that activates UNC-51-like kinase 1 (ULK1) with a reported EC50 of 18.94 nM. It is used in vitro to study autophagy, apoptosis, and mechanisms relevant to triple-negative breast cancer. Supplied as a solid and as a 10 mM solution in DMSO; consult the certificate of analysis for lot-specific purity and storage instructions.
- Potent ULK1 activation (EC50 = 18.94 nM).
- Supports studies of autophagy and apoptosis in cancer models.
- Available as solid and as a 10 mM solution in DMSO for assay flexibility.
- Hydrochloride salt form improves solubility for biological testing.
- Certificate of analysis available for lot-specific purity and storage instructions.
Medchemexpress LLC CC-115 (hydrochloride) | 1300118-55-1 | 98.0% | 372.81 | 25 MG
CC-115 hydrochloride is a potent dual inhibitor of DNA-PK and mTOR kinase. It effectively blocks both mTORC1 and mTORC2 signaling pathways, with IC50 values of 13 nM and 21 nM respectively. This product is intended for research use only.
- Potent and dual DNA-PK and mTOR kinase inhibitor
- Blocks both mTORC1 and mTORC2 signaling
- Exhibits good in vivo PK profiles across multiple species
- Demonstrates significant tumor volume reductions in tested models
- Sustains inhibition for prolonged periods
- Available in various sizes, including solid and pre-made solutions
Medchemexpress LLC Sotalol (hydrochloride) | 959-24-0 | 99.9% | 1 G
Sotalol hydrochloride is an orally active, non-selective β-adrenergic receptor blocker. It is a potent antiarrhythmic agent suitable for research on pediatric arrhythmias.
- Orally active
- Non-selective β-adrenergic receptor blocker
- Potent antiarrhythmic agent
- Blocks β-receptors
- Blocks potassium KCNH2 channels
- Acts as an antiepileptic agent
- Suitable for research on pediatric arrhythmias
Medchemexpress LLC His-Pro hydrochloride | 2415727-78-3 | 99.8% | 288.73 | 50 MG
His-Pro (Histidyl-proline) hydrochloride is a dipeptide consisting of histidyl and proline. It is for research use only and not sold to patients.
- Solid appearance
- White to off-white color
- Ships at room temperature in continental US
- Sealed storage, away from moisture and light
- Powder stable at -80°C for 2 years, -20°C for 1 year
- In solvent stable at -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC AFM-30a (hydrochloride) | 99.7% | 502.97 | 10 MG
AFM-30a hydrochloride is a potent and highly selective inhibitor of protein arginine deiminase 2 (PAD2). It binds to PAD2 with an EC50 value of 9.5 μM and inhibits H3 citrullination with an EC50 value of 0.4 μM. This compound is suitable for research into certain cancers and various autoimmune diseases, such as rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis.
- Potent protein arginine deiminase 2 (PAD2) inhibitor.
- Demonstrates excellent PAD2-selectivity.
- Binds to PAD2 with an EC50 value of 9.5 μM.
- Inhibits H3 citrullination with an EC50 value of 0.4 μM.
- Applicable for research on certain cancers and various autoimmune diseases, including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis.
- Exhibits low cytotoxicity in HEK293T/PAD2 cells.
- Suppresses NLRP3 signaling and reduces airway remodeling in PAD2-/-transgenic mice.
Medchemexpress LLC Metixene hydrochloride monohydrate | 7081-40-5 | >95.0% | 100MG
Metixene hydrochloride monohydrate | 7081-40-5 | >95.0% | 100MG
Medchemexpress LLC Cp94253 hydrochloride | 845861-39-4 | MFCD03453293 | 98.8% | 293.79 g/mol | C15H20ClN3O | 25 MG
CP94253 hydrochloride is the hydrochloride salt of a potent, selective 5-HT1B receptor agonist used in pharmacology and neuroscience research. It is characterized by CAS 845861-39-4, molecular formula C15H20ClN3O, and a molecular weight of 293.79 g/mol. Typical purity is about 98.8%, and the compound is provided in small-scale research pack sizes under sealed, moisture-free storage.
Medchemexpress LLC (E)-3-(2-((4-chlorophenyl)thio)phenyl)-N-(4-(dimethylamino)butyl)acrylamide hydrochloride | 1217201-17-6 | >99.0% | 425.41 | C21H25ClN2OS·HCl | 5 MG
A-350619 hydrochloride is a research-grade small-molecule activator of soluble guanylate cyclase (sGC). Supplied as the hydrochloride salt with high purity, it is used in preclinical studies probing NO-sGC signalling pathways and pharmacology related to erectile dysfunction.
- Activates soluble guanylate cyclase (sGC) in biochemical and cellular assays.
- Supplied as the hydrochloride salt for improved solubility.
- High purity suitable for research use (>99% HPLC).
- Molecular weight 425.41.
- Store at 4 °C to maintain stability.
- Applicable to preclinical studies of NO-sGC signalling and erectile dysfunction models.
Medchemexpress LLC 3-pyridinecarboxylic acid, 1,2,5,6-tetrahydro-, hydrochloride | 6027-91-4 | MFCD00055191 | 99.9% | 163.60 g/mol | C6H10ClNO2 | 50 MG
Guvacine hydrochloride is the hydrochloride salt of guvacine, a pyridine alkaloid that inhibits GABA transporters. Supplied for research use to study GABA uptake and transporter pharmacology, it has reported activity across cloned human and rat GAT subtypes.
- Inhibits GABA transporter activity; reported IC50s include 14 μM (human GAT-1).
- High purity (≈99.9%) confirmed by COA.
- Molecular weight 163.60 g/mol; molecular formula C6H10ClNO2.
- Available in multiple pack sizes, including 50 mg, and solution formats in DMSO.
- Suitable for biochemical assays and transporter studies.
- Supplied with analytical documentation such as datasheet and COA.
Medchemexpress LLC CPI-455 hydrochloride | 2095432-28-1 | 100.0% | 314.77 | C16H15ClN4O | 10 MG
CPI-455 hydrochloride is the hydrochloride salt of a potent pan-KDM5 inhibitor used as a research tool to probe KDM5-dependent epigenetic mechanisms. It inhibits KDM5 enzymes (IC50 = 10 nM for KDM5A), elevates H3K4me3 levels in cells, and is supplied with high purity for in vitro studies and mechanism-of-action experiments.
- Potent KDM5 inhibition (IC50 = 10 nM).
- Elevates global H3K4me3 levels in cells.
- High purity for reliable biochemical and cellular assays.
- Multiple package sizes for experimental flexibility.
- Recommended storage conditions provided to preserve stability.
- For research use only; not for clinical or human use.
Medchemexpress LLC Acetaminophen (Standard) | 103-90-2 | 100.0% | C8H9NO2 | 25 MG
Acetaminophen (Standard) is an analytical standard of Acetaminophen, primarily used for research and analytical applications. Also known as Paracetamol or 4-Acetamidophenol, it is a selective cyclooxygenase-2 (COX-2) inhibitor and a widely recognized antipyretic and analgesic agent. It also acts as a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.
- Analytical standard for research and analytical applications
- Reference standard for assays
- Suitable for HPLC, GC, and MS experiments
- Functions as a selective cyclooxygenase-2 (COX-2) inhibitor
- Widely used as an antipyretic and analgesic agent
- Acts as a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor
Medchemexpress LLC A 85380 hydrochloride | 174740-86-4 | 97.0% | 237.13 g/mol | C9H14Cl2N2O | 5 MG
A 85380 hydrochloride is a selective neuronal nicotinic acetylcholine receptor agonist with preference for the α4β2 subtype. Supplied as the hydrochloride salt in small research quantities, it is intended for in vitro pharmacology and receptor profiling studies and formulation work.
Medchemexpress LLC HY-15373 100mg , Fenretinide 4-HPR;(4-Hydroxyphenyl)retinamide CAS:65646-68-6 Purity:98%
Medchemexpress, HY-15373 100mg Fenretinide 4-HPR;(4-Hydroxyphenyl)retinamide CAS:65646-68-6 Formula:C26H33NO2 Purity:98% Fenretinide is a synthetic retinoid deriverative, binding to the retinoic acid receptors ( RAR ) at concentrations necessary to induce cell death. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Bepridil hydrochloride | 68099-86-5 | MFCD00065498 | 100.0% | 403.00 g/mol | C24H35ClN2O | 100 MG
Bepridil hydrochloride is the hydrochloride salt of bepridil, a non-selective calcium channel blocker with reported antianginal activity. Supplied as a white to light yellow solid, it is used as a research reagent in cardiovascular and electrophysiology studies.
- Cas number 68099-86-5
- Chemical formula C24H35ClN2O
- Molecular weight 403.00 g/mol
- High purity suitable for research applications
- Soluble in DMSO (100 mg/mL) and in water with ultrasonic assistance
- Store sealed, away from moisture; in solution store at -80°C for long-term stability
- Available in multiple pack sizes including 100 mg