Aminophenols
Medchemexpress LLC PD153035 (hydrochloride) | 183322-45-4 | 99.5% | 10 MG
PD153035 Hydrochloride is a potent ATP-competitive epidermal growth factor receptor (EGFR) inhibitor used in biochemical and cellular research to block EGFR signaling with very high affinity.
- Potent EGFR inhibitor; Ki ≈ 6 pM, IC50 ≈ 25 pM.
- High reported purity of 99.5%.
- Molecular weight 396.67 g·mol⁻¹; chemical formula C16H15BrClN3O2.
- Available as a 10 mg solid and as 10 mM solutions in DMSO.
- Suitable for biochemical assays and cell signaling studies.
Medchemexpress LLC Rhosin (hydrochloride) | 1281870-42-5 | 99.9% | 394.86 | 25 MG
Rhosin hydrochloride is a potent and specific inhibitor of the RhoA subfamily of Rho GTPases. It specifically binds to RhoA to inhibit RhoA-GEF interaction without interacting with Cdc42, Rac1, or the GEF, LARG. This compound induces cell apoptosis and promotes stress resiliency by enhancing D1-MSN plasticity and reducing hyperexcitability.
- Potent and specific inhibitor of the RhoA subfamily of Rho GTPases.
- Specifically binds to RhoA, inhibiting RhoA-GEF interaction.
- Induces cell apoptosis.
- Promotes stress resiliency.
- Reduces RhoA and p-MLC1 activities.
- Prevents social avoidance and blocks sucrose preference deficits.
- Attenuates stress-induced social avoidance and hyperexcitability.
- Enhances spine density in defeat mice.
Medchemexpress LLC SR9011 hydrochloride | 2070014-94-5 | 98.97% | 515.50 | 100 MG
SR9011 hydrochloride is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. It is for research use only.
- Increases REV-ERB-dependent repressor activity.
- Suppresses proliferation of breast cancer cell lines, regardless of ER or HER2 status.
- Causes cell cycle arrest prior to M phase by suppressing Cyclin A (CCNA2).
- Suppresses the expression of BMAL1 mRNA in HepG2 cells in a REV-ERBα/β-dependent manner.
- Displays reasonable plasma exposure in vivo.
Medchemexpress LLC BIIL-260 hydrochlori | 100MG
BIIL-260 hydrochloride is a potent and long-acting orally active leukotriene B(4) receptor LTB4 antagonist with anti-inflammatory activity BIIL-260 hydrochloride interacts with the LTB4 receptor in a saturable reversible and competitive manner has high affinity to the LTB4 receptor on isolated human neutrophil cell membranes with Ki values of 1 7 nM[1]
Medchemexpress LLC Metixene hydrochloride hydrate | 7081-40-5 | 99.9% | 1 ML
Metixene hydrochloride hydrate is supplied as a 10 mM solution in DMSO for research use. It is the hydrochloride salt of metixene, an anticholinergic and antiparkinsonian agent, provided in a 1 mL vial.
- Ready-to-use 10 mM solution in DMSO.
- Compact 1 mL vial for small-scale assays.
- High purity suitable for research applications.
- Molecular formula C20H26ClNOS, molecular weight 363.94 g/mol.
- Suitable for in vitro pharmacology and receptor studies.
Medchemexpress LLC BN82002 hydrochloride | 1049740-43-3 | 99.4% | 395.88 | 25 MG
BN82002 hydrochloride is a potent, selective, and irreversible inhibitor of the CDC25 phosphatase family. It inhibits CDC25A, CDC25B2, CDC25B3, CDC25C, and 25C-cat with IC50 values of 2.4, 3.9, 6.3, 5.4, and 4.6 μM, respectively. It demonstrates approximately 20-fold greater selectivity over CD45 tyrosine phosphatase. It is intended for research use only and is not sold to patients.
- Potent, selective, and irreversible inhibitor of CDC25 phosphatase family.
- Inhibits CDC25A, CDC25B2, CDC25B3, CDC25C, and 25C-cat at micromolar concentrations.
- Displays ~20-fold greater selectivity over CD45 tyrosine phosphatase.
- Shown to inhibit cell proliferation in several human tumor cell lines in vitro in a concentration-dependent manner.
- Causes cell cycle arrest at various stages.
Medchemexpress LLC ZZW-115 hydrochloride | 10122-45-9 | 98.09% | 573.97 | 25 MG
ZZW-115 hydrochloride is a potent NUPR1 inhibitor with a Kd of 2.1 μM. It induces tumor cell death through necroptosis and apoptosis, demonstrating anticancer activity.
- Effective in killing cancer cells with IC50 values ranging from 0.84 μM to 4.93 μM in various cell lines in vitro.
- Induces pancreatic cell death by necrosis and apoptosis, leading to decreased ATP production and increased ROS overproduction.
- Causes higher LDH release and greater caspase 3/7 activity in a concentration-dependent manner.
- Inhibits the growth of pancreatic xenografted tumors in mice when administered at 0.5-5 mg/kg daily for 30 days via injection.
- Dosage of 5 mg/kg for 30 days resulted in almost unmeasurable tumor sizes in some cases of C57BL/6 mice.
- Caused tumors to progressively decrease and almost disappear by the end of treatment in nude mice xenografted with MiaPaCa-2 cells at a 5 mg/kg dose.
![Medchemexpress LLC 5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline, 6,7,7a,8-tetrahydro-7-methyl- (7aR) | 548-08-3 | 99.9% | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000230584.png-250.jpg)
Medchemexpress LLC 5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline, 6,7,7a,8-tetrahydro-7-methyl- (7aR) | 548-08-3 | 99.9% | 5 MG
Roemerine is an isoquinoline alkaloid supplied as a white to off-white solid for research use. It has molecular formula C18H17NO2, a molecular weight of 279.33 g/mol, and analytical purity of 99.89% (HPLC). The compound is soluble in DMSO (100 mg/mL) and should be stored sealed, away from moisture and light.
- Isoquinoline alkaloid with reported antibacterial and CNS activity.
- High purity (99.9% by HPLC) suitable for analytical applications.
- Soluble in DMSO at 100 mg/mL; may require ultrasonic.
- Chemical identity confirmed by 1H NMR and MS.
- Store sealed at 4°C; in solvent, -80°C for 6 months or -20°C for 1 month.
Medchemexpress LLC 9-Hexadecenoic acid, 1,1'-[(9,10-dihydro-5,8-dihydroxy-9,10-dioxo-1,4-anthracenediyl)bis(imino-2,1-ethanediy... | 1349197-90-5 | 98.37% | 917.27 | 25 MG
di-Pal-MTO is a palm oil-based lipid created by combining the anticancer agent mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined in a molar ratio of 1:1, they effectively deliver siRNA to cells and enhance anticancer activity.
- Effective siRNA cell delivery
- Enhances anticancer activity
- Reduces tumor cell viability by 81% in vitro
- Reduces tumor size by 83% in vitro
Medchemexpress LLC BIIL-260 hydrochlori 10mg | 192581-24-1 | 10 MG
Biil-260 hydrochloride is the hydrochloride salt of BIIL-260, a potent, orally active leukotriene B4 (LTB4) receptor antagonist with anti-inflammatory activity. It binds the human LTB4 receptor reversibly and competitively (reported Ki ≈ 1.7 nM) and is supplied as a high-purity solid for research use.
- Potent LTB4 receptor antagonist with reported high affinity (Ki ≈ 1.7 nM).
- High purity solid suitable for in vitro and preclinical research.
- Available in small milligram quantities for compound screening and assay development.
- Soluble in DMSO for preparation of concentrated stock solutions.
Medchemexpress LLC Zilpaterol-d7 | 1217818-36-4 | C14H12D7N3O2 | 1 MG
Zilpaterol-d7 is a deuterium Zilpaterol. Zilpaterol is a β-adrenergic agonist that has been widely used to feed cattle.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC WR99210 hydrochlorid 5mg | 30711-93-4 | 5 MG
WR99210 hydrochloride is a potent dihydrofolate reductase (DHFR) inhibitor used in research on Plasmodium spp. and Toxoplasma gondii, and commonly used for selection of Plasmodium transfectants. The compound is supplied as the hydrochloride salt and is intended for laboratory research use only.
- Potent DHFR inhibitor (IC50 <0.075 nM).
- Used for antimalarial research and parasite selection.
- Supplied as a hydrochloride salt for improved solubility.
- Suitable for storage at -20°C in sealed containers away from moisture.
- Available in small research quantities for lab use (e.g., 5 mg).