Aminophenols
TARGETMOL CHEMICALS INC NECROPTOSIS-IN-1 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1. purity: 99%
TARGETMOL CHEMICALS INC TMS 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. TMS (23'45'-Tetramethoxystilbene) is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1). purity: 99%
Cayman Chemical N-acetyl-2-AmInophenol 50g
A derivative of acetaminophen; inhibits ADP- or arachidonic acid-induced platelet aggregation in isolated human platelet-rich plasma at 50 µM; decreases disease severity and prevents increases in paw volume in a rat model of collagen-induced arthritis at 1 mg/kg; has been used as a synthetic intermediate in the synthesis of compounds with antimalarial activity; a potential impurity in commercial preparations of acetaminophen
Ambeed 2 1HImidazol4yl ethan1amine di
2-(1H-Imidazol-4-yl)ethan-1-amine dihydrochloride, 56-92-8, 98%
Medchemexpress LLC Quercetagitrin | 548-75-4 | 100 MG
Quercetagitrin (Quercetagetin-7-O-glucoside) is a natural product isolated from the African marigold (Tagetes erecta). It possesses anti-inflammatory activity, inhibits Tau accumulation, and can reverse neuroinflammation and cognitive deficits in a P301S-Tau transgenic mouse model by inhibiting NF-κB activation. Quercetagitrin is also a dual-target inhibitor of PTPN6 (IC50 = 1 μM) and PTPN9 (IC50 = 1.7 μM) and enhances glucose uptake by mature C2C12 myoblasts. It is studied in research for Alzheimer's disease and type 2 diabetes.
- Possesses anti-inflammatory activity.
- Inhibits Tau accumulation.
- Can reverse neuroinflammation and cognitive deficits in a P301S-Tau transgenic mouse model by inhibiting NF-κB activation.
- Acts as a dual-target inhibitor of PTPN6 (IC50 = 1 μM) and PTPN9 (IC50 = 1.7 μM).
- Enhances glucose uptake by mature C2C12 myoblasts.
- Studied in research for Alzheimer's disease and type 2 diabetes.
Medchemexpress LLC V-0219 hydrochloride | 2922283-73-4 | 99.4% | C20H26ClF3N4O2 | 100 MG
V-0219 hydrochloride is an orally active, positive allosteric modulator (PAM) of the glucagon-like peptide-1 receptor (GLP-1R). It can be used for obesity-associated diabetes research.
- Orally active compound
- Positive allosteric modulator of the glucagon-like peptide-1 receptor (GLP-1R)
- Used for obesity-associated diabetes research
TARGETMOL CHEMICALS INC ZM 226600 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ZM 226600 is an ATP-sensitive potassium channel opener with an EC50 value of 500 nM. ZM226600 has an inhibitory effect on spontaneous bladder activity. purity: 100%
Medchemexpress LLC S65487 hydrochloride | 1644543-95-2 | 99.7% | 753.72 | 1 ML
S65487 hydrochloride (VOB560 hydrochloride) is a potent and selective Bcl-2 inhibitor, acting as a proagent of S55746. It is effective against BCL-2 mutations like G101V and D103Y, while showing low affinity for MCL-1, BFL-1, and BCL-XL. This compound is known to induce apoptosis and exhibits anticancer activities.
- Potent and selective Bcl-2 inhibitor.
- Proagent of S55746.
- Active against BCL-2 mutations (G101V and D103Y).
- Low affinity with MCL-1, BFL-1, and BCL-XL.
- Induces apoptosis.
- Exhibits anticancer activities.
- Induces complete regression in BCL-2-dependent RS4;11 tumors in vivo after a single intravenous administration.
- Shows strong and persistent tumor regression in xenograft models of lymphoid malignancies in mouse and rat when combined with the MCL-1-specific inhibitor S64315/MIK665.
Medchemexpress LLC Sotalol (hydrochloride) | 959-24-0 | 99.9% | 1 G
Sotalol hydrochloride is an orally active, non-selective β-adrenergic receptor blocker. It is a potent antiarrhythmic agent suitable for research on pediatric arrhythmias.
- Orally active
- Non-selective β-adrenergic receptor blocker
- Potent antiarrhythmic agent
- Blocks β-receptors
- Blocks potassium KCNH2 channels
- Acts as an antiepileptic agent
- Suitable for research on pediatric arrhythmias
Medchemexpress LLC SKI V | 24418-86-8 | 99.0% | 100 MG
SKI V is a potent, noncompetitive non-lipid sphingosine kinase (SPHK) inhibitor with an IC50 of 2 μM for GST-hSK. It also inhibits PI3K with an IC50 of 6 μM. This compound reduces the formation of sphingosine-1-phosphate (S1P), induces apoptosis, and demonstrates antitumor activity. It appears as a light yellow to yellow solid.
- Potently inhibits sphingosine kinase (SPHK)
- Inhibits PI3K
- Reduces sphingosine-1-phosphate (S1P) formation
- Induces apoptosis
- Exhibits antitumor activity
- Weak activity towards ERK2
- Does not inhibit PKC-α
eMolecules 303986-05-2 | 3-Chloro-N-(3-hydroxyphenyl)-2,2-dimethylpropanamide | Oakwood Chemical | MFCD00793397 | 227.690 | C11H14ClNO2 | 99.000 | CC(C)(CCl)C(=O)Nc1cccc(O)c1 | 100mg | 537712736
3-Chloro-N-(3-hydroxyphenyl)-2,2-dimethylpropanamide | Oakwood Chemical | 303986-05-2 | MFCD00793397 | 227.690 | C11H14ClNO2 | 99.000 | CC(C)(CCl)C(=O)Nc1cccc(O)c1 | 100mg | 537712736
Medchemexpress LLC CX-6258 hydrochloride hydrate | 1353858-99-7 | 99.2% | 10 MG
A research-grade hydrochloride hydrate salt of a potent pan-Pim kinase inhibitor intended for laboratory research use. It selectively inhibits Pim-1, Pim-2, and Pim-3 with reported IC50 values of 5 nM, 25 nM, and 16 nM, respectively. Characterization data and quality documents (SDS, COA, LCMS) are provided by the supplier.