Aminophenols
Medchemexpress LLC CC-401 hydrochloride | 1438391-30-0 | 99.35% | 100 MG
CC-401 hydrochloride is a potent inhibitor of all three forms of JNK, with a Ki ranging from 25 to 50 nM. It demonstrates significant selectivity for JNK over other related kinases and provides specific JNK inhibition in cell-based assays. This compound achieves its effect by competitively binding to the ATP binding site in JNK, thereby inhibiting the phosphorylation of the N-terminal activation domain of c-Jun.
- Potent inhibitor of all three forms of JNK (Ki: 25-50 nM).
- Exhibits at least 40-fold selectivity for JNK compared to other related kinases.
- Provides specific JNK inhibition at concentrations of 1 to 5 μM in cell-based assays.
- Competitively binds the ATP binding site in JNK.
- Inhibits phosphorylation of the N-terminal activation domain of c-Jun.
- Inhibits sorbitol-induced phosphorylation of c-Jun in HK-2 human tubular epithelial cells.
- Slows progression of proteinuria and prevents renal impairment in animal models.
Medchemexpress LLC LDC4297 hydrochloride | 2319747-14-1 | 98.2% | 10 MG
LDC4297 hydrochloride is a selective inhibitor of CDK7 with an IC50 value of 0.13 nM. It demonstrates broad antiviral activities against various viruses, including human cytomegalovirus (HCMV) replication with an EC50 value of 24.5 nM. Its antiviral spectrum extends to Herpesviridae, Adenoviridae, Poxviridae, Retroviridae, and Orthomyxoviridae, with EC50 values ranging from 0.02-1.21 μM. This compound is suitable for research related to infection.
- Selective inhibitor of CDK7
- Inhibits human cytomegalovirus (HCMV) replication
- Shows broad antiviral activities against multiple virus families
- Exhibits anti-proliferative activity against human fibroblast primary cultures
- Interferes with virus-induced Rb phosphorylation
- Demonstrates promising pharmacokinetic properties in CD1 mice
TARGETMOL CHEMICALS INC 4-Methylhistamine hydrochlorid
Also available in 1 mL, 1 mg, 2 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. 4-Methylhistamine hydrochloride has been shown to inhibit the activity of copper-dependent enzymes such as tyrosinase and dopamine beta-hydroxylase and has also been shown to modulate the expression of genes involved in cell cycle regulation and apoptosis. Purity 95%
Medchemexpress LLC L-742001 (hydrochloride) | 174605-64-2 | 99.0% | 450.35 | C23H25Cl2NO4 | 1 MG
L-742001 hydrochloride is a small-molecule inhibitor of the influenza virus PA endonuclease, supplied as a high-purity research reagent for in vitro virology and mechanism-of-action studies.
- High purity: 99.0% (analytical).
- Molecular weight: 450.35 g·mol⁻¹.
- CAS number: 174605-64-2.
- Mechanism: influenza PA endonuclease inhibitor.
- Reported activity: EC90 = 4.3 μM for vRNP activity in HEK293T cells.
- Suitable for in vitro virology and antiviral mechanism studies.
- Available in small research pack sizes, including 1 mg.
Medchemexpress LLC Axc-715 hydrochloride | 2490497-93-1 | 99.5% | 347.89 g/mol | C18H26ClN5 | 5 MG
AXC-715 hydrochloride is the hydrochloride salt of a small-molecule TLR7/TLR8 dual agonist used in preclinical research as an immunostimulant and as a building block for antibody-adjuvant immunoconjugates. It is supplied as a high-purity solid suitable for in vitro and in vivo studies, with recommended storage conditions to maintain stability.
Medchemexpress LLC Fasudil hydrochloride | 105628-07-7 | MFCD00943198 | 100.0% | 327.83 g/mol | C14H18ClN3O2S | 10 G
Fasudil hydrochloride is the hydrochloride salt of fasudil, a small-molecule inhibitor of RhoA/ROCK kinases used in biochemical and cell-based research. It is supplied for analytical and research applications and is typically handled as a solid powder with known solubility in DMSO and water.
Medchemexpress LLC UNC2025 hydrochloride | 2070015-17-5 | 100.0% | 513.12 | C28H41ClN6O | 10MM 1ML
UNC2025 hydrochloride is the hydrochloride salt of UNC2025, a potent, ATP-competitive, orally active dual MERTK/FLT3 inhibitor used in preclinical research on acute leukemia and receptor tyrosine kinase signaling. Supplied as a 10 mM solution in DMSO (1 mL), it exhibits sub-nanomolar inhibition of MERTK and FLT3 and demonstrates favorable pharmacokinetic properties for in vitro and in vivo studies.
- Potent MERTK and FLT3 inhibition at sub-nanomolar concentrations.
- Supplied as a ready-to-use 10 mM solution in DMSO for convenient dosing.
- High purity for reproducible experimental results.
- Light yellow to yellow solid appearance when provided as a dry compound.
- Store sealed and protect from moisture; in solution store at -80°C for long-term stability.
Medchemexpress LLC V-0219 hydrochloride | 2922283-73-4 | 99.4% | C20H26ClF3N4O2 | 100 MG
V-0219 hydrochloride is an orally active, positive allosteric modulator (PAM) of the glucagon-like peptide-1 receptor (GLP-1R). It can be used for obesity-associated diabetes research.
- Orally active compound
- Positive allosteric modulator of the glucagon-like peptide-1 receptor (GLP-1R)
- Used for obesity-associated diabetes research
Medchemexpress LLC Trv055 hydrochloride | 25849-90-5 | 98.88% | 868.42 | 5 MG
Trv055 hydrochloride | 25849-90-5 | 98.88% | 868.42 | 5 MG
Medchemexpress LLC SR9011 hydrochloride | 2070014-94-5 | 99.0% | 515.50 | 1 ML
SR9011 hydrochloride is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. This compound offers several key features and benefits:
- Acts as a REV-ERBα/β agonist
- Suppresses the expression of BMAL1 mRNA in HepG2 cells in a REV-ERBα/β-dependent manner
- Suppresses proliferation of breast cancer cell lines
- Appears to pause the cell cycle of breast cancer cells prior to M phase
- Causes an increase in cells in the G0/G1 phase and a decrease of cells in S and G2/M phase
- Displays reasonable plasma exposure in vivo
- Suppresses plasminogen activator inhibitor type 1 gene (Serpine1), cholesterol 7α-hydroxylase (Cyp7a1), and sterol response element binding protein (Srepf1) in a dose-dependent manner in mice
- Administration to mice results in loss of locomotor activity during the subject dark phase
Medchemexpress LLC HY-103128 5mg Medchemexpress, inS3-54A18 CAS:328998-53-4 Purity:>98%
Medchemexpress, HY-103128 5mg inS3-54A18 CAS:328998-53-4 inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Sigma Aldrich Fine Chemicals Biosciences Balsalazide Related Compound A United States Pharmacopeia (USP) Reference Standard | 1242567-07-2 (free acid) | 100MG
Balsalazide Related Compound A United States Pharmacopeia (USP) Reference Standard | Mol Wt: 330.2 | 1242567-07-2 (free acid) | 100MG
Medchemexpress LLC Sotorasib-d7 | 98.9% | 567.64 | 1 MG
Sotorasib-d7 (AMG-510-d7) is a deuterium-labeled Sotorasib. Sotorasib is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. It irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state, leading to the regression of KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC).
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules for quantitation during the drug development process.
- Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Cal-130 hydrochloride | 1431697-78-7 | 98.7% | 462.93 g/mol | C23H23ClN8O | 10 MG
Cal-130 hydrochloride is the hydrochloride salt of a small-molecule inhibitor selective for PI3Kδ (p110δ) and PI3Kγ (p110γ). It is supplied as a solid research reagent and shows low-nanomolar potency against its primary targets, with weaker activity toward other PI3K isoforms.
- Selective inhibition of PI3Kδ and PI3Kγ, low-nanomolar IC50 values
- Demonstrates activity against additional PI3K isoforms at higher concentrations
- High chemical purity suitable for in vitro and preclinical research
- Supplied as a solid, with common pack sizes suitable for laboratory studies
- Provided with documentation that includes molecular formula, molecular weight, and CAS number