Aminophenols
Medchemexpress LLC LY294002 (hydrochloride) | 934389-88-5 | MFCD01530034 | 99.9% | 343.8 g/mol | C19H18ClNO3 | 25 MG
LY294002 (hydrochloride) is a research-grade small-molecule inhibitor of phosphoinositide 3-kinases (PI3K) and casein kinase 2 (CK2), used to probe PI3K-mediated signaling, apoptosis, and autophagy in cellular and in vivo studies. It is supplied as a high-purity solid for laboratory research.
- Potent inhibitor of PI3K and CK2.
- High declared purity (>99.9%).
- Supplied as a solid for laboratory use.
- Molecular formula C19H18ClNO3; molecular weight 343.8 g/mol.
- Available in small research quantities such as 25 MG.
- Comes with an SDS and technical documentation for safe handling.
Medchemexpress LLC ZZW-115 hydrochloride | 10122-45-9 | 98.09% | 573.97 | 25 MG
ZZW-115 hydrochloride is a potent NUPR1 inhibitor with a Kd of 2.1 μM. It induces tumor cell death through necroptosis and apoptosis, demonstrating anticancer activity.
- Effective in killing cancer cells with IC50 values ranging from 0.84 μM to 4.93 μM in various cell lines in vitro.
- Induces pancreatic cell death by necrosis and apoptosis, leading to decreased ATP production and increased ROS overproduction.
- Causes higher LDH release and greater caspase 3/7 activity in a concentration-dependent manner.
- Inhibits the growth of pancreatic xenografted tumors in mice when administered at 0.5-5 mg/kg daily for 30 days via injection.
- Dosage of 5 mg/kg for 30 days resulted in almost unmeasurable tumor sizes in some cases of C57BL/6 mice.
- Caused tumors to progressively decrease and almost disappear by the end of treatment in nude mice xenografted with MiaPaCa-2 cells at a 5 mg/kg dose.
Medchemexpress LLC Rhosin (hydrochloride) | 1281870-42-5 | 99.9% | 394.86 | 25 MG
Rhosin hydrochloride is a potent and specific inhibitor of the RhoA subfamily of Rho GTPases. It specifically binds to RhoA to inhibit RhoA-GEF interaction without interacting with Cdc42, Rac1, or the GEF, LARG. This compound induces cell apoptosis and promotes stress resiliency by enhancing D1-MSN plasticity and reducing hyperexcitability.
- Potent and specific inhibitor of the RhoA subfamily of Rho GTPases.
- Specifically binds to RhoA, inhibiting RhoA-GEF interaction.
- Induces cell apoptosis.
- Promotes stress resiliency.
- Reduces RhoA and p-MLC1 activities.
- Prevents social avoidance and blocks sucrose preference deficits.
- Attenuates stress-induced social avoidance and hyperexcitability.
- Enhances spine density in defeat mice.
Medchemexpress LLC Ski V | 24418-86-8 | MFCD07772193 | 99.0% | 254.24 g/mol | C15H10O4 | 5 MG
SKI V is a small-molecule sphingosine kinase inhibitor reported to induce apoptosis and exhibit antitumor activity in vitro. The compound is supplied as a powder for laboratory research, with molecular formula C15H10O4 and molecular weight 254.24 g/mol. Solubility and activity data support formulation in DMSO and mixed aqueous vehicles for cell-based studies.
- Inhibits sphingosine kinase and PI3K signaling.
- Demonstrates in vitro activity (IC50 ≈ 2 μM for GST-hSK).
- Reported IC50 values for additional targets provide selectivity context.
- Supplied as a powder suitable for laboratory handling and storage.
- Soluble in DMSO (~50 mg/mL) and formulatable in aqueous vehicles with co-solvents.
- Molecular weight 254.24 g/mol; chemical formula C15H10O4.
- Intended for research use only.
Medchemexpress LLC Metixene hydrochloride hydrate | 7081-40-5 | 99.9% | 1 ML
Metixene hydrochloride hydrate is supplied as a 10 mM solution in DMSO for research use. It is the hydrochloride salt of metixene, an anticholinergic and antiparkinsonian agent, provided in a 1 mL vial.
- Ready-to-use 10 mM solution in DMSO.
- Compact 1 mL vial for small-scale assays.
- High purity suitable for research applications.
- Molecular formula C20H26ClNOS, molecular weight 363.94 g/mol.
- Suitable for in vitro pharmacology and receptor studies.
Medchemexpress LLC CX-6258 hydrochloride hydrate | 1353858-99-7 | 99.2% | 516.42 | 25 MG
CX-6258 hydrochloride hydrate is a potent and selective pan-Pim kinases inhibitor. It effectively inhibits Pim-1, Pim-2, and Pim-3, making it suitable for research into cancer and metabolic diseases.
- Potent and kinase selective pan-Pim kinases inhibitor
- Inhibits Pim-1 (IC50: 5 nM), Pim-2 (IC50: 25 nM), and Pim-3 (IC50: 16 nM)
- Causes dose-dependent inhibition of phosphorylation of pro-survival proteins, Bad and 4E-BP1
- Diminishes steady-state levels of ectopic NKX3.1 in PC3 cells
- Exhibits robust in vivo efficacy in Pim kinases driven tumor models
- Achieves 45% tumor growth inhibition at 50 mg/kg and 75% at 100 mg/kg in vivo
Medchemexpress LLC Riluzole hydrochloride | 850608-87-6 | 99.9% | 10 MM * 1 ML
Riluzole hydrochloride is an anticonvulsant agent that functions as a use-dependent Na+ channel blocker. It can also inhibit GABA uptake with an IC50 of 43 μM. This product is intended for research use only.
- Anticonvulsant agent
- Functions as a use-dependent Na+ channel blocker
- Inhibits GABA uptake
Medchemexpress LLC 4-pyridinecarboxylic acid dimethylaminoethyl ethylamino derivative, hydrochloride | 3026728-26-4 | 98.2% | 50 MG
KDM5-C49 hydrochloride is a small-molecule inhibitor of KDM5 family histone demethylases used for biochemical and cell-based research to probe demethylase activity.
- Potent KDM5 demethylase inhibitor.
- Purity 98.2% (HPLC, batch COA).
- Molecular weight 344.84 Da.
- Chemical formula C15H25ClN4O3.
- Appearance: solid-liquid mixture.
- Recommended storage: 4°C (sealed, away from moisture); in solvent -80°C (6 months), -20°C (1 month).
- Typical pack size: 50 MG.
Medchemexpress LLC Bepridil hydrochloride | 68099-86-5 | MFCD00065498 | 100.0% | 403.0 g/mol | C24H35ClN2O | 1 ML
Bepridil hydrochloride is the hydrochloride salt of bepridil, a non-selective calcium channel blocker used in research to probe cardiac ion channels and antianginal mechanisms. Supplied for research and analytical applications, it is available as a solid and as a prepared solution.
- Non-selective calcium channel blocker used in electrophysiology and pharmacology studies.
- Hydrochloride salt form enhances solubility for assays.
- Available as solid and as a 10 mM solution in DMSO for ready-to-use experiments.
- High purity (~99.98%) appropriate for analytical standards.
- Well-characterized identifiers: CAS 68099-86-5; molecular weight 403.0 g/mol.
eMolecules 56520-98-0 | 4-ETHYL-2-NITROPHENOL | MFCD16742721 | 1g
AstaTech | 4-ETHYL-2-NITROPHENOL | 1g | 268489544 | 36967 | 95.000 | 56520-98-0 | MFCD16742721 | 167.164 | C8H9NO3
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