Aminophenols
Medchemexpress LLC CBL0137 hydrochloride | 1197397-89-9 | 99.7% | 372.89 g/mol | C21H25ClN2O2 | 10 MG
CBL0137 hydrochloride is a research-grade small molecule that inhibits the histone chaperone FACT, activates p53, and suppresses NF-κB signaling. It is used in preclinical studies to probe chromatin regulation and anticancer mechanisms in cell-based and biochemical assays.
- Inhibits the histone chaperone FACT.
- Activates p53 in cell-based assays (IC50 ≈ 0.37 μM).
- Inhibits NF-κB signaling in cell-based assays (IC50 ≈ 0.47 μM).
- High chemical purity, typically reported as 99.7%.
- Available as solid packs and as a DMSO solution for in vitro use.
- Suitable for mechanistic studies, pathway modulation, and preclinical cancer research.
Medchemexpress LLC DMA-135 hydrochloride | 2237925-62-9 | 98.0% | C16H18ClN7O | 25 MG
DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication by binding to the EV71 SLII domain with moderately high affinity (KD= 520 nM). It induces conformational changes in RNA structure, stabilizing the ternary complex DMA135-RNA-AUF1, thereby inhibiting the translation and replication of EV71 with an IC50 of 7.54 μM. Cell-based studies indicate no significant toxicity.
- Inhibits enterovirus 71 (EV71) IRES-dependent translation
- Inhibits enterovirus 71 (EV71) replication
- Binds to EV71 SLII domain with moderately high affinity (KD= 520 nM)
- Induces conformational changes in RNA structure
- Stabilizes the ternary complex DMA135-RNA-AUF1
- No significant toxicity in cell-based studies
TARGETMOL CHEMICALS INC TMS 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. TMS (23'45'-Tetramethoxystilbene) is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1). purity: 99%
Medchemexpress LLC Afm32a hydrochloride | 2988594-85-8 | 99.4% | 517.00 | 1 MG
Afm32a hydrochloride | 2988594-85-8 | 99.4% | 517.00 | 1 MG
Medchemexpress LLC Nefopam hydrochloride | 23327-57-3 | 99.9% | 1 G
Nefopam hydrochloride is a centrally-acting, non-opioid analgesic drug used for the relief of moderate to severe pain. It targets β-catenin protein levels in mesenchymal cells both in-vitro and in-vivo. This benzoxazocine derivative inhibits β-catenin mediated signaling during skin wound repair.
- Relief of moderate to severe pain.
- Targets β-catenin protein level in mesenchymal cells.
- Non-opioid analgesic.
- Inhibits β-catenin mediated signaling.
Ambeed 2 1HImidazol4yl ethan1amine di
2-(1H-Imidazol-4-yl)ethan-1-amine dihydrochloride, 56-92-8, 98%
TARGETMOL CHEMICALS INC C29 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. C29 is a novel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells but only TLR2/1 signaling in murine macrophages. purity: 98%
Medchemexpress LLC CX-6258 hydrochloride hydrate | 1353858-99-7 | 99.2% | 10 MG
A research-grade hydrochloride hydrate salt of a potent pan-Pim kinase inhibitor intended for laboratory research use. It selectively inhibits Pim-1, Pim-2, and Pim-3 with reported IC50 values of 5 nM, 25 nM, and 16 nM, respectively. Characterization data and quality documents (SDS, COA, LCMS) are provided by the supplier.