Aminophenols
Medchemexpress LLC LDC4297 hydrochloride | 2319747-14-1 | 98.23% | 100 MG
LDC4297 hydrochloride is a selective inhibitor of CDK7 with an IC50 value of 0.13 nM. It inhibits human cytomegalovirus (HCMV) replication with an EC50 value of 24.5 nM. This compound demonstrates broad antiviral activities against various viruses, including Herpesviridae, Adenoviridae, Poxviridae, Retroviridae, and Orthomyxoviridae, with EC50 values ranging from 0.02-1.21 μM. LDC4297 hydrochloride is suitable for infection research.
- Selective CDK7 inhibitor (IC50: 0.13 nM)
- Inhibits human cytomegalovirus (HCMV) replication (EC50: 24.5 nM)
- Exhibits broad antiviral activities against various viruses (EC50: 0.02-1.21 μM)
- Useful for infection research
Medchemexpress LLC HLCL-61 hydrochloride | 1158279-20-9 | MFCD09446681 | 99.9% | 380.91 g/mol | C23H25ClN2O | 50 MG
HLCL-61 hydrochloride is a first-in-class small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5), provided as a solid research reagent with characterized purity and storage recommendations for biochemical and cellular studies.
- First-in-class PRMT5 inhibitor for research applications.
- High purity suitable for biochemical and cellular assays.
- Supplied as a solid, white to off-white powder.
- Documented molecular formula and molecular weight for experiment planning.
- Storage guidance provided for solvent and dry conditions to preserve stability.
- For research use only; not for human or animal therapeutic use.
Medchemexpress LLC L-742001 hydrochloride | 174605-64-2 | 99.0% | 450.35 | C23H25Cl2NO4 | 5 MG
L-742001 hydrochloride is a research-grade small-molecule inhibitor of influenza virus PA endonuclease, supplied as a high-purity solid for in vitro studies. It reduces vRNP activity in HEK293T cells with an EC90 of 4.3 μM and is intended for laboratory research use only.
- Inhibits influenza PA endonuclease, EC90 of 4.3 μM for vRNP activity in HEK293T cells.
- High purity (99.0%) solid suitable for research applications.
- Molecular weight 450.35 and formula C23H25Cl2NO4.
- Recommended storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
- For research use only; not for human or veterinary use.
Medchemexpress LLC R 59-022 (hydrochloride) | 93076-98-3 | MFCD34676749 | 98.9% | 496.04 g·mol⁻¹ | C27H27ClFN3OS | 50 MG
R 59-022 hydrochloride is the hydrochloride salt of R 59-022, a research compound that acts as a diacylglycerol kinase (DGK) inhibitor (reported IC50 ≈ 2.8 μM). It is used in cellular and biochemical assays to modulate diacylglycerol/protein kinase C signaling and to probe 5-HT receptor-related pathways. The material is supplied as an off-white solid (CAS 93076-98-3) with formula C27H27ClFN3OS and molecular weight 496.04 g·mol⁻¹.
- DGK inhibitor with reported IC50 ≈ 2.8 μM.
- Modulates protein kinase C and diacylglycerol signaling in cells.
- Hydrochloride salt form for improved handling and solubility in polar solvents.
- High purity suitable for research applications.
- Soluble in DMSO for preparation of stock solutions.
Medchemexpress LLC Prilocaine-d7 hydrochloride | 1786-81-8 | 98.2% | 100 UG
Prilocaine-d7 (hydrochloride) is a deuterium-labeled form of Prilocaine (hydrochloride). Prilocaine hydrochloride is an amino amide and a Na, K-ATPase inhibitor known for its neurotoxic effects. Stable heavy isotopes like deuterium are incorporated into drug molecules primarily as tracers for quantitation during drug development, with potential to affect pharmacokinetic and metabolic profiles.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC ST-836 hydrochloride | 1415564-68-9 | C23H35ClN4OS | 1 ML
ST-836 hydrochloride is a potent dopamine receptor ligand with potential for Parkinson's disease research. It exhibits Ki values of 4.5 nM for D3 and 132 nM for D2 receptors. This compound is provided as a 10 mM solution in dimethyl sulfoxide (DMSO).
- Potent dopamine receptor ligand
- Potential for Parkinson's disease research
- Enhanced water solubility and stability in salt form
Medchemexpress LLC NS8593 (hydrochloride) | 875755-24-1 | 99.8% | 299.80 | 25 MG
NS8593 hydrochloride is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels). It reversibly inhibits SK3-mediated currents with a Kd value of 77 nM. It also inhibits SK1-3 subtypes in a Ca2+-dependent manner (Kds of 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca2+), but it does not affect intermediate and large conductance Ca2+-activated K+ channels (hIK and hBK channels).
- Potent and selective small conductance Ca2+-activated K+ channels (SK channels) inhibitor.
- Reversibly inhibits SK3-mediated currents.
- Active on apamin-insensitive SK3 channels.
- Affects firing rate and pattern of dopaminergic neurons in vivo.
Medchemexpress LLC RS 67333 hydrochloride | 168986-60-5 | MFCD00938576 | 99.7% | 389.36 g/mol | C19H30Cl2N2O2 | 1 ML
RS 67333 hydrochloride is a research reagent that functions as a potent, selective partial agonist of the 5-HT4 (serotonin 4) receptor. It is supplied as a ready-to-use 10 mM solution in DMSO (1 mL) and in multiple solid pack sizes for use in pharmacology and neuroscience studies, including neuroprotection and Alzheimer's disease research. CAS: 168986-60-5; purity ~99.7%.
- Potent, selective 5-HT4 receptor partial agonist.
- Offered as 10 mM solution in DMSO (1 mL) and multiple solid sizes.
- High listed purity (~99.7%).
- Suitable for pharmacology and neuroscience research applications.
- Provided with datasheet, certificate of analysis, and safety data sheet.
Medchemexpress LLC MK-3207 hydrochloride | 957116-20-0 | MFCD16038934 | 98.1% | 594.05 g/mol | C31H30ClF2N5O3 | 1 ML
MK-3207 Hydrochloride is a potent, orally bioavailable CGRP receptor antagonist used in research on CGRP-mediated signaling and migraine-related pathways. It exhibits sub-nanomolar potency and high selectivity versus related receptors, and is provided in solution and solid forms for laboratory use.
- Potent CGRP receptor antagonist with IC50 0.12 nM and Ki 0.024 nM.
- Highly selective versus AM1, AM2, CTR, and AMY3 receptors.
- Available as a 10 mM solution (1 mL) and as solid quantities for preparation.
- Purity approximately 98.1% by analytical methods.
- Molecular formula C31H30ClF2N5O3; molecular weight 594.05 g/mol.
- Provided with structural identifiers to support research (SMILES, PubChem CID).
Medchemexpress LLC MK-0493 hydrochloride | 455957-71-8 | 98.8% | 582.55 g/mol | C30H39Cl2F2N3O2 | 5 MG
MK-0493 hydrochloride is a potent, orally active, and selective agonist of the melanocortin receptor 4 (MC4R) used as a research tool to study appetite regulation and energy homeostasis. It is supplied as a high-purity hydrochloride salt suitable for analytical and preclinical applications.
- Potent, selective MC4R agonist for receptor pharmacology studies.
- Orally active probe for appetite and energy intake research.
- High purity (98.8%) solid suitable for analytical and preclinical use.
- Available in mg-scale solid quantities and as a DMSO solution.
- Soluble in DMSO; handle and store according to standard compound precautions.
Medchemexpress LLC Biotin-4-aminophenol | 901770-40-9 | >99.45% | C16H21N3O3S | 1 ML
Biotin-4-aminophenol is a biotin-phenol analog that generates free radicals and conjugates to tyrosine residues in proteins. It is noted for its more efficient and selective conjugation compared to previously reported BP1. This product is intended for research use only.
- Generates free radicals
- Conjugates to tyrosine residues in proteins
- More efficient and selective conjugation than BP1
- For research use only
Medchemexpress LLC DMA-135 hydrochloride | 2237925-62-9 | 98.0% | C16H18ClN7O | 25 MG
DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication by binding to the EV71 SLII domain with moderately high affinity (KD= 520 nM). It induces conformational changes in RNA structure, stabilizing the ternary complex DMA135-RNA-AUF1, thereby inhibiting the translation and replication of EV71 with an IC50 of 7.54 μM. Cell-based studies indicate no significant toxicity.
- Inhibits enterovirus 71 (EV71) IRES-dependent translation
- Inhibits enterovirus 71 (EV71) replication
- Binds to EV71 SLII domain with moderately high affinity (KD= 520 nM)
- Induces conformational changes in RNA structure
- Stabilizes the ternary complex DMA135-RNA-AUF1
- No significant toxicity in cell-based studies
U.S. Pharmacopeia 4-Aminophenol, 123-30-8, MFCD00007869, 100mg
Molecular Formula C6H7NO, Molecular Weight 109.127, Melting Point 356 - 374 °F (180 - 190 °C), Boiling Point 543.2 °F (284 °C) (decomposes), Synonyms: p-Aminophenol, 4-Amino-1-hydroxybenzene
Medchemexpress LLC dTAGV-1 hydrochloride | 2624313-16-0 | 99.8% | C68H91ClN6O14S | 10MG
dTAGV-1 hydrochloride is a selective PROTAC degrader that targets FKBP12F36V-tagged proteins, enabling rapid and tunable protein degradation in cellular and in vivo studies. Supplied as a hydrochloride salt with high reported purity, it is intended for research applications in chemical biology and targeted protein degradation.
- Selective degradation of FKBP12F36V-tagged proteins.
- Effective in cellular and in vivo assays.
- Supplied as hydrochloride salt for improved stability.
- High reported purity suitable for research use.
- Available in small milligram scales for laboratory studies.
- Recommended storage conditions support long-term stability.