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Filtered Search Results
Medchemexpress LLC 5-(1,3-benzodioxol-5-ylmethylene)-2,4-thiazolidinedione | 6318-41-8 | MFCD18382117 | 99.0% | 249.24 g/mol | C11H7NO4S | 1 ML
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AS-041164 is a potent, selective, orally active PI3Kγ inhibitor supplied either as a ready-to-use solution (10 mM in DMSO, 1 mL) or as a solid in multiple mg sizes for research applications investigating PI3Kγ signaling and inflammatory responses.
- Potent, selective PI3Kγ inhibition with IC50 ≈ 70 nM.
- Available as 10 mM solution (1 mL) or solids in multiple milligram sizes.
- High purity (≈99.0%) suitable for research use.
- Soluble in DMSO, convenient for in vitro assays.
- Store protected from light; in solvent conditions extend stability at low temperatures.
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Matrix Scientific 2-IODOPHENOL-25G
2-Iodophenol, 98%; 25g,C6H5IO, MFCD00013963, mw 220.01, [533-58-4]
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Medchemexpress LLC Nrf2 (69-84) | 1364173-77-2 | 95.3% | 1858.01 | 5 MG
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Nrf2 (69-84) is a peptide fragment of the Nrf2 protein, featuring the critical ETGE motif. This key region binds to the Kelch domain of the Keap1 protein. It is utilized in research to explore Nrf2's role in the development and progression of various diseases.
- Peptide fragment of Nrf2 protein
- Contains critical ETGE motif
- Binds to Kelch domain of Keap1 protein
- Used for research on Nrf2 in disease development
- Relevant for cancer, neurodegenerative, and inflammatory disease studies
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Medchemexpress LLC Oblimersen sodium | 98.09% | 5684.61 (free acid) | 1 MG
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Oblimersen sodium functions as a BCL-2 inhibitor by targeting BCL-2 RNA. It specifically binds to the first six codons of the bcl-2 mRNA sequence, leading to the degradation of bcl-2 mRNA and inducing apoptosis by down-regulating the expression of Bcl-2. Oblimersen sodium can be used for cancer research.
- Functions as a BCL-2 inhibitor
- Targets BCL-2 RNA
- Binds to the first six codons of bcl-2 mRNA sequence
- Leads to degradation of bcl-2 mRNA
- Induces apoptosis by down-regulating Bcl-2 expression
- Suitable for cancer research
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Apexbio Technology LLC 2,4,6-Triiodophenol 609-23-4 25mg
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2 4 6-Triiodophenol (CAS 609-23-4) is a small molecule inhibitor known to block the biosynthetic pathway of leukotriene B4 (LTB4) thereby modulating the production of pro-inflammatory mediators By targeting LTB4 synthesis it serves as a valuable tool for studying inflammatory processes and related signaling mechanisms Additionally this compound has been reported to induce apoptosis in murine blastocyst-stage cells making it relevant for investigations into early embryonic development embryotoxicity and the regulation of apoptotic pathways
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Apexbio Technology LLC Tolazoline HCl 59-97-2 10mM (in 1mL DMSO)
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Tolazoline hydrochloride (CAS 59-97-2) is a small molecule that functions as a competitive antagonist at -adrenergic receptors exhibiting non-selective affinity for both 1- and 2-adrenoceptor subtypes By inhibiting endogenous catecholamine binding tolazoline modulates vasomotor tone and vascular smooth muscle contraction This pharmacological profile enables researchers to investigate adrenergic signaling pathways and the physiological roles of -adrenergic receptors Tolazoline HCl is widely utilized in studies of vascular function receptor pharmacology and the characterization of sympathetic nervous system mechanisms
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Medchemexpress LLC Activin Receptor Type IIB Antibody (YA2345) | 10 UL
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Activin Receptor Type IIB (ACVR2B) is a transmembrane serine/threonine kinase that forms an activin receptor complex with type I receptors. It functions as the primary receptor for activin-A, activin-B, and inhibin-A, regulating diverse processes including neuronal differentiation/survival, hair follicle cycling, pituitary FSH production, wound healing, extracellular matrix formation, immunosuppression and carcinogenesis. Upon activation, ACVR2B phosphorylates type I receptors to initiate SMAD2/SMAD3-SMAD4-mediated transcriptional regulation.
- Derived from rabbit host
- Reacts with human, mouse, and rat samples
- Non-conjugated
- SwissProt ID: Q13705
- Research field: Signal Transduction
- Liquid appearance
- Application: WB (1:500-1:1000 dilution)
- Storage at -20°C for 1 year; avoid repeated freeze/thaw cycles
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Medchemexpress LLC Activin Receptor Type I Antibody (YA2943) | 10 UL
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Activin Receptor Type I (ACVR1) is a bone morphogenetic protein (BMP) type I receptor crucial for diverse biological processes including bone, heart, cartilage, nervous system, and reproductive system development. It forms heterotetrameric complexes with type II receptors, becoming transphosphorylated upon ligand binding to mediate BMP signaling. ACVR1 also suppresses TGFβ/activin pathway signaling.
- Suitable for Western Blotting (WB) at 1:500-1:1000 dilution
- Suitable for Immunoprecipitation (IP) at 1:50 dilution
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Medchemexpress LLC ODN TTAGGG sodium | 1801724-76-4 | Sequence: 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3' | 1 MG
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ODN TTAGGG sodium is an inhibitory oligonucleotide and functions as a TLR9, AIM2, and cGAS antagonist. This product is immunosuppressive, inhibiting AIM2 inflammasome activation and cGAS activation by competing with DNA. It is suitable for use in the study of lupus erythematosus and other related autoimmune diseases.
- Functions as an inhibitory oligonucleotide.
- Acts as a TLR9, AIM2, and cGAS antagonist.
- Possesses immunosuppressive properties.
- Inhibits AIM2 inflammasome activation.
- Inhibits cGAS activation through DNA competition.
- Can be used for research into lupus erythematosus.
- Useful in the study of other related autoimmune diseases.
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Medchemexpress LLC 1-Benzyl-4-piperidone | 3612-20-2 | 189.25 | 100 G
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1-Benzyl-4-piperidone is a laboratory chemical primarily used for the manufacture of various substances. This compound has an appearance of a liquid, a molecular formula of C12H15NO, and a molecular weight of 189.25. It is intended for research use only by experienced personnel.
- Identified for use as a laboratory chemical
- Used in the manufacture of substances
- Liquid appearance
- Boiling point of 278.5°C at 760 mmHg
- Flash point of 71°C
- Relative density of 1.021 g/cm³
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Medchemexpress LLC Rho-Kinase-IN-2 | 2573071-18-6 | C20H25FN4O2 | 50 MG
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Rho-Kinase-IN-2 (Compound 23) is an orally active, selective, and CNS-penetrant Rho Kinase (ROCK) inhibitor (ROCK2 IC50 = 3 nM). It can be used in Huntington's research. In vitro studies show it increases AKT phosphorylation and decreases MYPT1 phosphorylation. In vivo, it demonstrates dose- and time-dependent ROCK1 and ROCK2 target engagement and tolerability in mouse models. Oral administration decreases mean arterial, systolic, and diastolic blood pressure.
- Orally active, selective, and CNS-penetrant Rho Kinase (ROCK) inhibitor
- ROCK2 IC50 of 3 nM
- Increases AKT phosphorylation and decreases MYPT1 phosphorylation in A7r5 and PANC1 cells
- Demonstrates dose- and time-dependent ROCK1 and ROCK2 target engagement in mice
- Used in Huntington's research
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Medchemexpress LLC γ-Decalactone | 706-14-9 | MFCD00005404 | 250 G
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γ-Decalactone | 706-14-9 | MFCD00005404 | 250 G
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eMolecules 2-AMINO-3-BROMOPHENOL 5G
5000225244 2-AMINO-3-BROMOPHENOL 5G
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eMolecules 2-CHLORO-1 10-PHENANTHROL 100G
5000158725 2-CHLORO-1 10-PHENANTHROL 100G
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eMolecules 6-CHLORO-3-FLUOROPICOLINONI 5G
5000158733 6-CHLORO-3-FLUOROPICOLINONI 5G
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