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Filtered Search Results
Medchemexpress LLC 3-Acetylthiophene | 1468-83-3 | MFCD00005468 | 126.18 | 10 G
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3-Acetylthiophene is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It is intended for research use only.
- Solid appearance
- Light brown to brown color
- Chemical formula: C6H6OS
- Soluble in DMSO
- Store at 4°C, protected from light
- For in-solvent storage, -80°C for 6 months or -20°C for 1 month
- Ships at room temperature (continental US)
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Medchemexpress LLC 2-Amino-5-fluorophenol | 53981-24-1 | 127.12 | 10 G
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2-Amino-5-fluorophenol is an isomer of aminofluorophenol and a HONO generator. It reacts with nitrogen dioxide (NO2) via two pathways to form nitrous acid (HONO): hydrogen abstraction from the hydroxyl group and hydrogen abstraction from the amino group, with both the amino and hydroxyl groups participating in the reaction in the transition state. This product is for research use only.
- Solid appearance, light brown to gray
- Molecular formula: C6H6FNO
- Purity: 99.77% (GC)
- Storage at 4°C, protected from light
- In solvent storage: -80°C for 6 months; -20°C for 1 month (protect from light)
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Medchemexpress LLC m-Iodophenol | 626-02-8 | 220.01 | 100 G
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m-Iodophenol is a chemical compound identified as a protaetia brevitarsis attractant. It is intended for research use only.
- Purity of 99.89%
- Storage at 4°C, protected from light
- In solvent, storage at -80°C for 6 months; -20°C for 1 month, protected from light
- Solid below 42°C; liquid above 44°C
- Yellow to brown in color
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Medchemexpress LLC EGFR-IN-70 | 2926716-96-1 | C31H36ClN5O5S | 1 ML
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EGFR-IN-70 (compound 18j) is a potent EGFR inhibitor with IC50 values of 23.6 nM for EGFRLR/TM/CS and 307.5 nM for EGFRWT. It exhibits anti-proliferative activity and suppresses the phosphorylation of EGFR. This compound is suitable for cancer research.
- Potent EGFR inhibitor with IC50 values of 23.6 nM (EGFRLR/TM/CS) and 307.5 nM (EGFRWT)
- Exhibits anti-proliferative activity
- Suppresses phosphorylation of the EGFR
- Suitable for cancer research
- Demonstrates antiproliferative activity against human A-431 cells (IC50 of 2.003 nM)
- Exhibits antiproliferative activity against mouse BaF3 cells expressing EGFR L858R/T790M/C797S mutant (IC50 of 0.036 μM)
- Suppresses phosphorylation of EGFR and downstream signaling ERK level
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Medchemexpress LLC N-[4-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]phenyl]-1-(2-furanylmethyl)-5-oxo-pyrrolidinecarboxamide | 2784577-71-3 | MFCD00701047 | C24H19ClN4O4 | 1 ML
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RLX-33 is a potent, selective, and blood-brain barrier (BBB) penetrant relaxin family peptide 3 (RXFP3) antagonist. This compound blocks relaxin-3-induced ERK1/2 phosphorylation and can prevent the stimulation of food intake induced by the RXFP3-selective agonist R3/I5 in rats, making it suitable for metabolic syndrome research.
- Potent and selective RXFP3 antagonist
- Blood-brain barrier penetrant
- Blocks relaxin-3-induced ERK1/2 phosphorylation
- Attenuates R3/I5-induced feeding
- Good brain penetration
- Highly protein-bound in rat plasma
- Useful for metabolic syndrome research
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eMolecules EMOLECULES INC
5000482126 NITROSONIUM TETRAFLUOROBOR 25G
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eMolecules 16090-02-1 | FLUORESCENT BRIGHTENER 71 | AstaTech | MFCD00071913 | 924.920 | C40H38N12Na2O8S2 | 95.000 | [Na+].[Na+].[O-]S(=O)(=O)c1cc(Nc2nc(Nc3ccccc3)nc(n2)N2CCOCC2)ccc1\C=C\c1ccc(Nc2nc(Nc3ccccc3)nc(n2)N2CCOCC2)cc1S([O-])(=O)=O | 5g | 721757026
FLUORESCENT BRIGHTENER 71 | AstaTech | 16090-02-1 | MFCD00071913 | 924.920 | C40H38N12Na2O8S2 | 95.000 | [Na+].[Na+].[O-]S(=O)(=O)c1cc(Nc2nc(Nc3ccccc3)nc(n2)N2CCOCC2)ccc1\C=C\c1ccc(Nc2nc(Nc3ccccc3)nc(n2)N2CCOCC2)cc1S([O-])(=O)=O | 5g | 721757026
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eMolecules 22731-83-5 | Sulfonimidoyldibenzene | Ambeed | MFCD00507872 | 217.290 | C12H11NOS | 97.000 | N=S(=O)(c1ccccc1)c1ccccc1 | 25g | 847282536
Sulfonimidoyldibenzene | Ambeed | 22731-83-5 | MFCD00507872 | 217.290 | C12H11NOS | 97.000 | N=S(=O)(c1ccccc1)c1ccccc1 | 25g | 847282536
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Medchemexpress LLC 8-Bromo-cAMP sodium salt | 76939-46-3 | 99.9% | 430.08 | 100 MG
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8-Bromo-cAMP sodium salt is a cyclic AMP analog and an activator of cyclic AMP-dependent protein kinase (PKA). It has shown anti-proliferative and apoptotic effects against various cancer cells.
- Enhances reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells.
- Induces apoptosis in esophageal cancer cell line (Eca-109).
- Induces decidualization of human endometrial stromal cells.
- Reduces tumor growth in CT26 tumor mice.
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Ambeed 2 2 Dimethyl 1 1 biphenyl 4 4
2,2'-Dimethyl-[1,1'-biphenyl]-4,4'-diamine, 84-67-3, 97%
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eMolecules 23761-23-1 | 3-Oxo-Cyclobutanecarboxylicacid | AA Blocks LLC | MFCD00100900 | 114.100 | C5H6O3 | 0.000 | OC(=O)C1CC(=O)C1 | 10g | 410165109
3-Oxo-Cyclobutanecarboxylicacid | AA Blocks LLC | 23761-23-1 | MFCD00100900 | 114.100 | C5H6O3 | 0.000 | OC(=O)C1CC(=O)C1 | 10g | 410165109
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Medchemexpress LLC ODN 24987 sodium | DNA, d(P-thio)(C-C-T-G-G-C-c7G-G-G-G), sodium salt | 1 MG
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ODN 24987 sodium is a Guanine-modified inhibitory oligonucleotide (ODN), targeting TLR9. It can inhibit IL-6 and IFN-α release and can be used for researching immune disorders. The sequence is 5'-C-C-T-G-G-C-c7G-G-G-G-3'.
- Guanine-modified inhibitory oligonucleotide
- Targets toll-like receptor 9 (TLR9)
- Inhibits IL-6 and IFN-α release
- Suitable for immune disorder research
- Sequence: 5'-C-C-T-G-G-C-c7G-G-G-G-3'
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Medchemexpress LLC SY-LB-35 | 2603461-70-5 | C15H11N3O | 1 ML
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SY-LB-35 is a potent bone morphogenetic protein (BMP) receptor agonist that can significantly increase cell number and viability in the C2C12 myoblast cell line. It also shifts the cell cycle towards the S and G2/M phases.
- Stimulates canonical Smad and non-canonical PI3K/Akt, ERK, p38, and JNK intracellular signaling pathways.
- Increases cell number and cell viability in C2C12 myoblast cells.
- Causes cell cycle shifting to S and G2/M phases in C2C12 cells.
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Medchemexpress LLC Rho-Kinase-IN-2 | 2573071-18-6 | C20H25FN4O2 | 100 MG
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Rho-Kinase-IN-2 (Compound 23) is an orally active, selective, and CNS-penetrant Rho Kinase (ROCK) inhibitor with a ROCK2 IC50 of 3 nM, making it suitable for Huntington's research. It increases AKT phosphorylation and decreases MYPT1 phosphorylation both in vitro and in vivo. This product is intended for research use only.
- Orally active, selective, and CNS-penetrant ROCK inhibitor
- Targeted inhibition of ROCK2 with an IC50 of 3 nM
- Increases AKT phosphorylation and decreases MYPT1 phosphorylation in A7r5 and PANC1 cells
- Demonstrates dose- and time-dependent ROCK1 and ROCK2 target engagement in vivo
- Shows excellent tolerability in mouse models
- Decreases mean arterial, systolic, and diastolic blood pressure and heart rate in CD1 mice
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Medchemexpress LLC Rho-Kinase-IN-2 | 2573071-18-6 | C20H25FN4O2 | 50 MG
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Rho-Kinase-IN-2 (Compound 23) is an orally active, selective, and CNS-penetrant Rho Kinase (ROCK) inhibitor (ROCK2 IC50 = 3 nM). It can be used in Huntington's research. In vitro studies show it increases AKT phosphorylation and decreases MYPT1 phosphorylation. In vivo, it demonstrates dose- and time-dependent ROCK1 and ROCK2 target engagement and tolerability in mouse models. Oral administration decreases mean arterial, systolic, and diastolic blood pressure.
- Orally active, selective, and CNS-penetrant Rho Kinase (ROCK) inhibitor
- ROCK2 IC50 of 3 nM
- Increases AKT phosphorylation and decreases MYPT1 phosphorylation in A7r5 and PANC1 cells
- Demonstrates dose- and time-dependent ROCK1 and ROCK2 target engagement in mice
- Used in Huntington's research
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