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Filtered Search Results
Medchemexpress LLC Tulobuterol hydrochloride | 56776-01-3 | 99.8% | 264.19 | 500 MG
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Tulobuterol hydrochloride is a long-acting β2-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. It is also a sympathomimetic agent used as a transdermal patch, increasing normal diaphragm muscle strength. Additionally, Tulobuterol hydrochloride can inhibit rhinovirus replication and modulate airway inflammation.
- Long-acting β2-adrenoceptor agonist
- Reduces frequency of exacerbations in chronic obstructive pulmonary disease and bronchial asthma
- Sympathomimetic agent used as a transdermal patch
- Increases normal diaphragm muscle strength
- Inhibits rhinovirus replication and modulates airway inflammation
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Medchemexpress LLC Maprotiline (hydrochloride) | 10347-81-6 | 99.99% | 100 MG
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Maprotiline (hydrochloride) (Standard) is the analytical standard of Maprotiline (hydrochloride). It is a highly selective noradrenergic reuptake inhibitor with strong antidepressant, antitumor, and neuropathic pain-relieving effects. It induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1. This compound is an analytical standard used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Analytical standard
- Highly selective noradrenergic reuptake inhibitor
- Strong antidepressant effects
- Antitumor effects
- Neuropathic pain-relieving effects
- Induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1
- Used in qualitative research experiments
- Used in quantitative research experiments
- Used in methodological research experiments
- Suitable for HPLC, GC, and MS applications
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Medchemexpress LLC Bupivacaine (hydrochloride) | 18010-40-7 | 100.0% | 50 MG
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Bupivacaine hydrochloride (Standard) is an analytical standard intended for research and analytical applications. It acts as an NMDA receptor inhibitor and can block sodium, L-calcium, and potassium channels. Potently blocking SCN5A channels with an IC50 of 69.5 μM, it can be used for chronic pain research.
- Analytical standard for research and analytical applications.
- NMDA receptor inhibitor.
- Blocks sodium, L-calcium, and potassium channels.
- Potently blocks SCN5A channels with an IC50 of 69.5 μM.
- Useful for chronic pain research.
- Commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
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Medchemexpress LLC Samuraciclib hydrochloride | 1805789-54-1 | MFCD31657343 | 99.9% | 430.97 g/mol | C22H31ClN6O | 100 MG
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Samuraciclib hydrochloride is a potent, selective, ATP-competitive, and orally active inhibitor of cyclin-dependent kinase 7 (CDK7) used in preclinical research. It inhibits proliferation of cancer cell lines and has demonstrated anti-tumor activity in vitro, making it a tool compound for studying CDK7-related transcriptional control and apoptosis pathways.
- Potent, selective CDK7 inhibition (IC50 ~41 nM).
- Orally active compound suitable for in vitro and preclinical studies.
- Shown to inhibit cancer cell growth (GI50 0.2-0.3 μM in breast cancer lines).
- Applicable for research on transcriptional regulation and apoptosis mechanisms.
- Supplied as a stable solid with recommended refrigerated storage to maintain integrity.
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Medchemexpress LLC Icapamespib hydrochloride | 2267287-26-1 | 98.7% | 599.32 | 50 MG
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Icapamespib hydrochloride | 2267287-26-1 | 98.7% | 599.32 | 50 MG
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Medchemexpress LLC Icapamespib hydrochloride | 2267287-26-1 | 98.74% | 599.32 | 100 MG
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Icapamespib hydrochloride | 2267287-26-1 | 98.74% | 599.32 | 100 MG
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Medchemexpress LLC (1S,2S)-2-PCCA hydrochloride | 1609563-70-3 | 99.7% | 528.56 g/mol | C30H39Cl2N3O | 1 ML
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(1S,2S)-2-PCCA hydrochloride is the less active diastereomer of 2-PCCA, a small-molecule agonist of the GPR88 receptor. Supplied as a 10 mM solution in DMSO for in vitro receptor and cell-based assays, it inhibits GPR88-mediated cAMP production with a reported EC50 of 116 nM in HEK293 cells. The compound has a molecular weight of 528.56 g/mol and CAS number 1609563-70-3.
- Ready-to-use 10 mM solution in DMSO, 1 mL.
- Reported activity: inhibits GPR88-mediated cAMP production (EC50 116 nM in HEK293 cells).
- High purity (99.7%) by LCMS.
- Molecular weight 528.56 g/mol; formula C30H39Cl2N3O.
- Intended for in vitro research; consult the safety data sheet for handling and storage.
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Medchemexpress LLC H3R antagonist 1 hydrochloride | 2319790-07-1 | 377.87 | 1 ML
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H3R antagonist 1 hydrochloride is a histamine receptor 3 (H3R) inverse agonist that can be utilized for the study of multiple sclerosis. It increases the expression levels of myelin-associated glycoprotein (MAG) and myelin basic protein (MBP) in differentiating oligodendrocytes, promoting oligodendrocyte precursor cell (OPC) differentiation in vitro.
- Promotes oligodendrocyte precursor cell (OPC) differentiation
- Increases expression of myelin-associated glycoprotein (MAG) and myelin basic protein (MBP)
- Enhances remyelination in demyelination models
- Increases Forskolin-stimulated cAMP level in primary OPCs
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Medchemexpress LLC IACS-010759 | 1570496-34-2 | 99.7% | 562.56 | 100 MG
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IACS-010759 is an orally active, potent mitochondrial complex I inhibitor of oxidative phosphorylation (OXPHOS). It inhibits proliferation and induces apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS, making it suitable for research in relapsed/refractory AML and solid tumors.
- Potent mitochondrial complex I inhibitor
- Inhibits proliferation and induces apoptosis in cancer models
- Potential for solid tumor research
- Suitable for acute myeloid leukemia (AML) research
- Exhibits low plasma clearance and prolonged terminal half-life
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Medchemexpress LLC Ifebemtinib (hydrochloride) | 1227948-82-4 | 99.2% | 625.01 | 10 MM/1 ML
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Ifebemtinib is an orally bioavailable inhibitor of the non-receptor, cytoplasmic tyrosine kinase protein tyrosine kinase 2 (FAK: PTK2) with potential antineoplastic activity. It targets and inhibits PTK2 in an adenosine triphosphate (ATP)-competitive manner, preventing PTK2-mediated downstream signaling and inhibiting migration, proliferation, invasion, and survival in PTK2-overexpressing tumor cells.
- Orally bioavailable inhibitor of FAK1/PTK2
- Targets and inhibits PTK2 in an ATP-competitive manner
- Prevents PTK2-mediated downstream signaling
- Inhibits migration, proliferation, invasion, and survival in PTK2-overexpressing tumor cells
- Stable under recommended storage conditions
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Medchemexpress LLC PF-06815345 hydrochloride | 2334434-49-8 | 98.15% | 634.49 | 10 MG
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PF-06815345 hydrochloride is an orally active and potent inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) with an IC50 value of 13.4 μM. It significantly decreases the PCSK9 level in vivo in mouse. A clinical trial (NCT02654899) sponsored by Pfizer for Hypercholesterolemia started in November 2015 and is in Phase 1.
- Potent PCSK9 inhibitor with an IC50 of 13.4 μM.
- Significantly decreases PCSK9 levels in vivo.
- Shows CLint values of <82.9 μL/min/mg in human enterocytes and 97.6 μL/min/mg in human hepatocytes.
- Lowers plasma PCSK9 by 72% at 500 mg/kg in a humanized PCSK9 mouse model.
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Medchemexpress LLC 1-Heptadecanoyl-2-hy | 25MG
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1-Heptadecanoyl-2-hy | 25MG
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Medchemexpress LLC Bomedemstat hydrochloride | 99.94% | 556.07 | 10 MILLIGRAM
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Bomedemstat hydrochloride is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. It increases H3K4 and H3K9 methylation, which alters gene expression. This compound exhibits anti-cancer activities, inhibiting cancer cell proliferation and inducing apoptosis.
- Orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor.
- Increases H3K4 and H3K9 methylation.
- Shows anti-cancer activities.
- Inhibits cancer cell proliferation.
- Induces apoptosis.
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Ambeed 1R 3S 5R 2 tertButoxycarbonyl
(1R,3S,5R)-2-(tert-Butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid, 197142-34-0, 97%
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Ambeed 2Thiophenemethylamine
2-Thiophenemethylamine, 27757-85-3, 97%
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