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Filtered Search Results
Medchemexpress LLC Zimelidine dihydrochloride | 60525-15-7 | 98.08% | 390.15 | 500 MG
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Zimelidine dihydrochloride is a potent and selective inhibitor of serotonin 5-HT uptake and SERT, acting as an antidepressant.
- Potent and selective inhibitor of serotonin 5-HT uptake and SERT.
- Antidepressant.
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Medchemexpress LLC 1-azido-2-(2-bromoethoxy)ethane | 1144106-65-9 | 99.5% | C4H8BrN3O | 10MG
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Bromo-PEG1-C2-azide is a bifunctional PEG-based linker bearing a terminal bromide and an azide functional group. Supplied as a colorless to light yellow liquid, it is used in PROTAC synthesis and bioconjugation workflows to enable alkylation at the bromide and click reactions at the azide, facilitating modular assembly of conjugates for research applications.
- Enables copper-catalyzed azide-alkyne cycloaddition for robust conjugation.
- Provides a reactive bromide for alkylation and substitution chemistry.
- Short PEG spacer improves solubility and linker flexibility.
- High reported purity supports reproducible reactions.
- Stable under recommended storage conditions for extended shelf life.
- Suitable for small-scale synthesis and linker assembly workflows.
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Medchemexpress LLC 50 BP DNA MARKER 250UL
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50 BP DNA MARKER 250UL
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Medchemexpress LLC 3-BENZYL-6-BROMO-1H- 250 mg
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3-BENZYL-6-BROMO-1H- 250MG
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Medchemexpress LLC Regorafenib hydrochloride | 835621-07-3 | MFCD22417053 | C21H16Cl2F4N4O3 | 10MG
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Regorafenib hydrochloride is the hydrochloride salt of regorafenib, a potent multi-target kinase inhibitor. Supplied as an analytical standard for research use, it inhibits VEGFR1/2/3, PDGFRβ, Kit, RET, and Raf-1 with low-nanomolar potency, and is intended for in vitro and analytical applications such as HPLC, GC, and MS.
- Multi-target kinase inhibitor active against VEGFR1/2/3, PDGFRβ, Kit, RET, and Raf-1.
- Low-nanomolar potency reported for key kinase targets.
- High purity analytical standard (99.6%).
- Intended for research and analytical applications, including HPLC, GC, and MS.
- Suitable for method development and quantitative assays.
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Medchemexpress LLC Avotaciclib hydrochloride | 1983983-41-0 | 99.75% | 317.73 | 100 MG
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Avotaciclib hydrochloride (Synonyms: BEY1107 hydrochloride) is an orally active cyclin-dependent kinase 1 (CDK1) inhibitor. It can inhibit the proliferation and induce apoptosis of tumor cells, making it suitable for cancer research, including pancreatic cancer and lung cancer.
- Orally active CDK1 inhibitor.
- Inhibits proliferation of tumor cells.
- Induces apoptosis in tumor cells.
- Applicable in research for various cancers like pancreatic cancer and lung cancer.
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Medchemexpress LLC RGLS4326 sodium | 99.7% | 3082.42 (free acid) | 1 MG
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RGLS4326 sodium is a first-in-class, short oligonucleotide inhibitor of microRNA-17 (miR-17). It can be used for the research of autosomal dominant polycystic kidney disease (ADPKD).
- First-in-class short oligonucleotide inhibitor
- Inhibits microRNA-17 (miR-17)
- Used for research of autosomal dominant polycystic kidney disease (ADPKD)
- Inhibits miR-17 function in HeLa cells with an EC50 value of 28.3 nM
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Medchemexpress LLC Bomedemstat hydrochloride | 99.9% | 556.07 | 1 ML
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Bomedemstat hydrochloride | 99.9% | 556.07 | 1 ML
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Medchemexpress LLC Bomedemstat hydrochloride | 99.9% | 556.07 | 100 MG
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Bomedemstat hydrochloride | 99.9% | 556.07 | 100 MG
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Medchemexpress LLC Estrogen receptor modulator 1 | 63676-22-2 | 99.9% | 242.29 | 25 MG
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Estrogen receptor modulator 1 (compound 18) is an orally active and selective estrogen receptor modulator (SERM), with a pIC50 of 0.46. It induces regression of Tamoxifen-resistant, hormone-independent xenograft tumors.
- Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor beta (EC50: 17 nM).
- Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor alpha (EC50: 50 nM).
- Agonist activity in transcriptional activation assay in SH-SY5Y neuroblastoma cells expressing Estrogen receptor beta (EC50: 10 nM).
- Inhibits colony formation at 100 nM for 10 days.
- Significantly inhibits growth of cells and induces apoptosis at 100 nM for 9 days.
- Induces regression of T47D:A18/PKCα tumors in vivo at 1.5 mg/animal daily for 2 weeks.
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Medchemexpress LLC SN-008 | 2249106-01-0 | 99.68% | C25H19FN2O3S | 1 ML
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SN-008 is a less active analog of SN-011 and can be utilized as a negative control. It is intended for research use only.
- Less active analog of SN-011
- Can be utilized as a negative control
- Intended for research use only
- High purity of 99.68%
- Molecular weight of 446.49
- Appears as a white to off-white solid
- Soluble in DMSO
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Medchemexpress LLC Palbociclib hydrochloride | 571189-11-2 | 100.0% | C24H30ClN7O2 | 2 G
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Palbociclib hydrochloride is an orally active, selective inhibitor of CDK4 and CDK6, with IC50 values of 11 nM and 16 nM respectively. It demonstrates potent anti-proliferative activity and is known to induce cell cycle arrest in various cancer cells. This compound is suitable for research in HR-positive and HER2-negative breast cancer, as well as hepatocellular carcinoma.
- Orally active selective CDK4 and CDK6 inhibitor
- Potent anti-proliferative activity
- Induces cell cycle arrest in cancer cells
- Used in research for HR-positive and HER2-negative breast cancer and hepatocellular carcinoma
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Medchemexpress LLC Edaravone | 89-25-8 | MFCD00003138 | 99.9% | C10H10N2O | 25 G
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Edaravone is a potent free radical scavenger and neuroprotective agent. It exhibits preventative and therapeutic effects against glutamate toxicity by reducing apoptosis and necrosis. It also inhibits MMP-9-related brain hemorrhage and ameliorates neuronal damage in brain ischemia. This compound is intended for research use only, supporting studies on neuroprotection and free radical scavenging.
- Strong free radical scavenger
- Inhibits MMP-9-related brain hemorrhage
- Demonstrates neuroprotective activity against H2O2-induced cell damage
- Shows neuroprotective activity against glutamate-induced toxicity
- Inhibits arachidonic acid and adenosine diphosphate-induced platelet aggregation
- Reduces astrogliosis and apoptosis
- Increases protein expression of TGF-β1, VEGF, and MMP9
- Suppresses TNF-α expression
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Medchemexpress LLC K-01-162 | 677746-25-7 | 98.0% | C15H14BrN | 1 ML
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K 01-162, also known as K162, is an inhibitor designed to prevent the fibril formation of Aβ peptides and mitigate their neurotoxicity. This compound demonstrates binding affinity with Aβ42 peptide (EC50 of 80 nM) and directly with AβO (KD of 19 μM). It can penetrate the brain, making it a valuable tool for Alzheimer's disease research.
- Inhibits fibril formation of Aβ peptides
- Eliminates neurotoxicity of Aβ peptides
- Binds with Aβ42 peptide (EC50 of 80 nM)
- Binds directly to AβO (KD of 19 μM)
- Reduces intracellular AβO levels
- Blocks synaptic binding activity of AβO in mouse hippocampal neurons
- Attenuates amyloid load in vivo
- Capable of penetrating the brain
- Suitable for Alzheimer's disease research
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Medchemexpress LLC Dorzolamide hydrochloride | 130693-82-2 | 99.9% | C10H17ClN2O4S3 | 25 MG
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Dorzolamide hydrochloride is a potent carbonic anhydrase II inhibitor, demonstrating strong activity against red blood cell CA-II and CA-I. This compound also exhibits anti-tumor properties, making it suitable for various research applications.
- Potent carbonic anhydrase II inhibitor
- Exhibits anti-tumor activity
- Soluble in DMSO and H2O
- Shipped at room temperature
- Sealed storage at 4°C, away from moisture
- Stock solution storage at -80°C for 6 months or -20°C for 1 month
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