Halophenols
Medchemexpress LLC Lesinurad sodium | 1151516-14-1 | C17H13BrN3NaO2S | 1 ML
Lesinurad sodium is a URAT1 and OAT inhibitor, identified as a substrate for kidney transporters OAT1 and OAT3. It is a novel selective uric acid reabsorption inhibitor (SURI) that increases proximal renal tubule urate excretion.
- Acts as a URAT1 and OAT inhibitor
- Functions as a substrate for kidney transporters OAT1 and OAT3
- Increases proximal renal tubule urate excretion
- Inhibits CYP2C9 and CYP2C8
- Suitable for research use only
Medchemexpress LLC Veratraldehyde | 120-14-9 | 166.18 | 1 KG
Veratraldehyde is an orally active aromatic compound that exhibits antibacterial properties. It can be naturally isolated from the essential oils of plants such as peppermint and ginger. This compound functions as an antibacterial agent by targeting the PilY1 protein and has demonstrated activity against *Pseudomonas aeruginosa*. Additionally, Veratraldehyde is noted for its repellent effects against mosquitoes and ticks and can also be utilized as a flavoring agent.
- Orally active aromatic compound
- Natural origin: isolated from plant essential oils like peppermint and ginger
- Antibacterial agent: effectively targets the PilY1 protein to inhibit bacterial growth
- Activity against *Pseudomonas aeruginosa*
- Repellent effect: acts as a repellent against mosquitoes and ticks
- Flavoring agent
Medchemexpress LLC Benzetimide hydrochloride | 5633-14-7 | 99.4% | 1 ML
Benzetimide hydrochloride is a muscarinic acetylcholine receptor (mAChR) antagonist, also identified as R4929 and Dioxatrine. This product is intended for research use only and is not for human use.
- Acts as a muscarinic acetylcholine receptor (mAChR) antagonist.
- Suitable for various research applications including neurological, eye or ear, neurodegenerative diseases, and Parkinson's disease.
- Useful in GPCR/G Protein, neuronal signaling, and mAChR studies.
- High purity of 99.44%.
- Molecular weight of 398.93.
- Appearance: solid, white to off-white.
- Soluble in DMSO and water.
Medchemexpress LLC Levobunolol hydrochloride | 27912-14-7 | 100.0% | 1 ML
Levobunolol hydrochloride is a non-selective β-adrenergic antagonist and vasodilator used in research on glaucoma and ocular hypertension. It functions by dilating ciliary arteries, increasing ocular blood flow, and blocking calcium ion influx. This compound also demonstrates unique vascular regulatory activity, protecting ocular blood flow and promoting corneal repair.
- Blocks calcium ion influx and reduces vascular smooth muscle sensitivity to calcium.
- Inhibits the β-receptor signaling pathway.
- Inhibits expression of proliferation markers in corneal cells.
- Accelerates healing of mechanical injury in rabbit models without inhibiting corneal epithelial regeneration.
- Inhibits histamine-induced vasoconstriction and intracellular calcium elevation.
Medchemexpress LLC Fosinopril sodium | 88889-14-9 | 99.2% | 1 ML
Fosinopril sodium is an ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor. It is used for the treatment of hypertension and some types of chronic heart failure. This product is an analytical standard intended for research and analytical applications. It has a purity of 99.2%.
- Ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor
- Treats hypertension
- Treats some types of chronic heart failure
- Intended for research and analytical applications
- Purity of 99.2%
Medchemexpress LLC Cyclohexanone, 5-methyl-2-(1-methylethyl)- | 10458-14-7 | 250 G
Menthone is an orally active monoterpene isolated from plants and Mentha oil, possessing antibacterial, antitumor, antioxidation, and antivirus properties. As a main volatile component of essential oil, it also exhibits anti-inflammatory properties in Schistosoma mansoni infection and rheumatoid arthritis.
- Colorless to light yellow liquid appearance
- High purity of 99.96% by GC
- Molecular formula C10H18O, molecular weight 154.25
- Density of 0.896 g/cm3
- Possesses antibacterial, antitumor, antioxidation, and antivirus properties
- Exhibits anti-inflammatory properties in various infections and conditions
- Inhibits secretion of proinflammatory cytokine TNF-α
- Modulates STAT1 activation and protects against allergic inflammation
Medchemexpress LLC Epoprostenol sodium | 61849-14-7 | 98.03% | C20H31NaO5 | 1 MG
Epoprostenol sodium (Prostaglandin I2) sodium salt is the synthetic form of the natural prostaglandin derivative prostacyclin (prostaglandin I2). It is registered worldwide for the treatment of Pulmonary arterial hypertension (PAH) and is used in pulmonary hypertension and transplantation as a potent inhibitor of platelet aggregation.
- Registered worldwide for the treatment of pulmonary arterial hypertension (PAH).
- Used in pulmonary hypertension and transplantation.
- Potent inhibitor of platelet aggregation.
- Induces apoptosis in PAH-PASMCs by upregulating the expression of IP receptor and Fas ligand (FasL).
- Storage at -20°C, sealed, away from moisture.
- Compound is unstable in solutions; freshly prepared solutions are recommended.
Medchemexpress LLC Cyclohexanone, 5-methyl-2-(1-methylethyl)- | 10458-14-7 | MFCD00062998 | 25 G
Cyclohexanone, 5-methyl-2-(1-methylethyl)- | 10458-14-7 | MFCD00062998 | 25 G
Medchemexpress LLC (E)-Cardamonin ((E)-Cardamomin) | 19309-14-9 | 270.28 | 1 ML
(E)-Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM.
- Purity: 99.84%
- Appearance: Solid
- Color: Light yellow to yellow
- Formula: C16H14O4
- Molecular weight: 270.28
- Structure classification: Flavonoids, chalcones, phenols, polyphenols
- Initial source: Plants Zingiberaceae Alpinia katsumadai Hayata
- Storage: Powder at -20°C for 3 years, 4°C for 2 years; in solvent at -80°C for 2 years, -20°C for 1 year
- Solubility (in vitro): DMSO at 150 mg/mL (554.98 mM); requires ultrasonic
- Target: hTRPA1 cation channel with an IC50 of 454 nM
Medchemexpress LLC PLpro inhibitor | 1093070-14-4 | 99.9% | 346.42 | 10 MM 1 ML
PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with an IC50 of 2.6 μM. It inhibits SARS-CoV-2 PLpro with an IC50 of 5.0 μM and an EC50 of 21.0 μM. It is a noncovalent inhibitor that blocks SARS virus replication and shows significant antiviral activity with EC50 values of 13.1 μM without toxicity up to the highest concentration tested. The increasing antiviral potency correlates with the in vitro inhibition of PLpro, suggesting a direct action on the enzyme in cells.
- Potent inhibitor of papain-like protease (PLpro) (IC50 = 2.6 μM).
- Inhibits SARS-CoV-2 PLpro (IC50 = 5.0 μM, EC50 = 21.0 μM).
- Displays significant antiviral activity (EC50 = 13.1 μM) without toxicity.
- Noncovalent class of inhibitor that blocks SARS virus replication.
Medchemexpress LLC Kras G12d Inhibitor 14 | 2765254-39-3 | 98.88% | C20H19F3N4OS | 1 ML
KRAS G12D inhibitor 14 is a potent KRAS G12D inhibitor with a KD of 33 nM for binding to KRAS G12D protein. It decreases the active form of KRAS G12D (KRAS G12D-GTP) but not KRAS G13D. For research use only, not for sale to patients.
- Binds to KRAS G12D protein with a KD of 33 nM.
- Decreases the active form of KRAS G12D (KRAS G12D-GTP) but does not affect KRAS G13D.
- Shows antiproliferative activity with an IC50 of 2.1 μM against KRAS G12D-mutated cells.
- Causes efficient apoptosis in SW1990 and CT26 cancer cells.
- Down-regulates phosphorylated Raf and Erk in CT26 and SW1990 cancer cell lines.
- Exhibits significant antitumor efficacy in a CT26 tumor model with a tumor growth inhibition (TGI) of 42% or 53% at doses of 40 mg/kg or 60 mg/kg (i.p.), without apparent toxicity.
eMolecules Ambeed / Diethyl 14-dihydro-26-dimethyl-35-pyridinedicarboxylate / 100g / 571783169 / A193361 / / 1149-23-1 / MFCD00005951 / 253.298 / C13H19NO4
Ambeed / Diethyl 14-dihydro-26-dimethyl-35-pyridinedicarboxylate / 100g / 571783169 / A193361 / / 1149-23-1 / MFCD00005951 / 253.298 / C13H19NO4
Sigma Aldrich Hexahydro-1,4-thiazepine hydrochloride
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Medchemexpress LLC PG 116800 | 291533-11-4 | 99.8% | C24H27N3O7S | 1 MG
PG 116800 is an orally active MMP inhibitor. It demonstrates high affinity for MMP-2, -3, -8, -9, -13, and -14, with substantially lower affinity for MMP-1 and -7. This compound can be utilized in research pertaining to knee osteoarthritis.
- Orally active MMP inhibitor
- High affinity for MMP-2, -3, -8, -9, -13, and -14
- Lower affinity for MMP-1 and -7
- Can be used for knee osteoarthritis research
Medchemexpress LLC (4S)-4-(3-bromophenyl)-4,5-dihydro-2-(methylthio)thiazole-5-carboxylic acid | 330203-01-5 | 99.0% | 422.32 g·mol⁻¹ | C17H12BrNO3S2 | 1 ML
TC HSD 21 is a potent, selective inhibitor of 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) with an IC50 of 14 nM. It is supplied as a 10 mM solution in DMSO (1 mL vial) and has a molecular formula of C17H12BrNO3S2, molecular weight 422.32 g·mol⁻¹, and purity 99.0%.
- Inhibits 17β-HSD3 with an IC50 of 14 nM.
- Shows excellent selectivity over other 17β-HSD isoenzymes and nuclear receptors.
- Supplied as a 10 mM solution in DMSO (1 mL) for ready-to-use assays.
- High purity (99.0%) for reliable biochemical studies.
- Molecular weight 422.32 g·mol⁻¹ and molecular formula C17H12BrNO3S2.
- Recommended storage: powder -20°C for long term; in solvent -80°C for up to 6 months.
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