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Filtered Search Results
Medchemexpress LLC Edonerpic (maleate) | 519187-97-4 | 99.8% | 407.48 | 200 MG
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Edonerpic maleate is a novel neurotrophic agent that can inhibit amyloid-β peptides (Aβ). It preserves cortical neurons in the presence of Aβ(1-42), prevents oxidative stress-induced neuronal death, and significantly increases neurite length. It also ameliorates deficits in adult neurogenesis and spatial memory.
- Novel neurotrophic agent
- Inhibits amyloid-β peptides (Aβ)
- Preserves cortical neurons in the presence of Aβ(1-42)
- Prevents oxidative stress-induced neuronal death at 0.1 and 1 μM
- Almost completely prevents GSH reduction at 0.1 and 1 μM
- Significantly increases neurite length at 0.1 and 1 μM
- Ameliorates deficits in adult neurogenesis and spatial memory in rats infused i.c.v. with amyloid-beta peptide
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Medchemexpress LLC Vicriviroc maleate | 599179-03-0 | MFCD09833218 | 99.9% | 649.70 | 1 ML
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Vicriviroc maleate is a potent, selective, and orally bioavailable CCR5 antagonist. It is CNS penetrated with a Ki of 2.5 nM. This compound effectively inhibits HIV-1 in PBMC cells across various strains.
- Potent and selective CCR5 antagonist
- Oral bioavailable and CNS penetrated
- Inhibits HIV-1 in PBMC cells
- Active against multiple HIV-1 strains
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Medchemexpress LLC Neratinib maleate | 915942-22-2 | 99.7% | 673.11 | 100 MG
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Neratinib maleate is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC50s of 59 nM and 92 nM, respectively. It is for research use only.
- Orally available
- Irreversible inhibitor
- Highly selective HER2 and EGFR inhibitor
- Inhibits proliferation of cell lines with high HER-2 levels
- Less active in cell lines expressing neither HER-2 nor EGFR
- Arrests BT474 cell cycle at G1-S phase
- Inhibits MAPK and Akt phosphorylation
- Down-regulates cyclin D1 levels
- Induces p27
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Medchemexpress LLC Avitinib maleate | 1557268-88-8 | 99.9% | 603.60 | 25 MG
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Avitinib maleate is a third-generation, irreversible, and orally active selective EGFR inhibitor. It has IC50 values of 0.18 nM against both EGFR L858R and EGFR T790M, and 7.68 nM against wild-type EGFR. It is also a BTK inhibitor, inducing apoptosis and inhibiting BTK phosphorylation in mantle cell lymphoma. It exhibits anticancer effects.
- Third-generation, irreversible, and orally active selective EGFR inhibitor.
- Potent against EGFR L858R, EGFR T790M, and wild-type EGFR.
- BTK inhibitor.
- Induces apoptosis.
- Inhibits phosphorylation of BTK in mantle cell lymphoma.
- Exhibits anticancer effects.
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eMolecules METHYL PROPIOLATE 500G
5000224643 METHYL PROPIOLATE 500G
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000379371 BGT226 MALEATE 50MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000379499 BGT226 MALEATE 1MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000387226 EDONERPIC MALEATE 50MG
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Medchemexpress LLC Sumanirole maleate (U-95666E; PNU-95666E) | 179386-44-8 | 99.8% | C15H17N3O5 | 100 MG
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Sumanirole maleate (U-95666E; PNU-95666E) is a highly selective D2 receptor full agonist with an ED50 of about 46 nM. It plays an important role in the research of Parkinson's disease and restless leg syndrome.
- Highly selective D2 receptor full agonist
- ED50 of about 46 nM
- Valuable tool compound for basic research
- Identifies neurobiological mechanisms based on dopamine D2-linked mechanism of action
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Apexbio Technology LLC APEXBIO TECHNOLOGY LLC
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5000568032 CIPROXIFAN-MALEATE-10MG
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Apexbio Technology LLC APEXBIO TECHNOLOGY LLC
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5000568071 CIPROXIFAN-MALEATE-5MG
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Chemscene CHEMSCENE
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5000575429 TERT-BUTYL PROPIOLATE 100G
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Medchemexpress LLC 4-PPBP maleate | 201216-39-9 | MFCD00209909 | 99.6% | 409.52 g·mol-1 | C25H31NO4 | 25 MG
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4-PPBP maleate is a research-grade small-molecule sigma-1 receptor ligand and NMDA receptor modulator supplied as the maleate salt. It is intended for in vitro and preclinical studies and is not for human or clinical use. The compound is well characterized and provided with analytical purity suitable for laboratory research.
- Potent sigma-1 receptor ligand and agonist.
- Selective, non-competitive modulator of NR1a/2B NMDA receptors.
- Supplied as the maleate salt for stability and handling.
- High purity suitable for research applications (approximately 99.6%).
- Well-characterized molecular identity: C25H31NO4; MW 409.52 g·mol-1.
- Available in small laboratory pack sizes (25 mg).
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Medchemexpress LLC Dizocilpine maleate | 77086-22-7 | C20H19NO4 | 100 MG
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Dizocilpine maleate is a potent, selective, and non-competitive NMDA receptor antagonist. It effectively blocks currents induced by N-Me-D-Asp and can be utilized in various research applications, including inducing schizophrenia models.
- Potent, selective, and non-competitive NMDA receptor antagonist
- Causes progressive, long-lasting blockade of current induced by N-Me-D-Asp
- Used to induce schizophrenia models
- Kd of 37.2 nM in rat brain membranes
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Medchemexpress LLC Dizocilpine maleate | 77086-22-7 | C20H19NO4 | 1 ML
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Dizocilpine maleate (MK-801 maleate) is a potent, selective, and non-competitive antagonist of the NMDA receptor. It has a Kd of 37.2 nM in rat brain membranes and causes a progressive, long-lasting blockade of N-Me-D-Asp and NMDA-induced currents.
- Potent, selective, and non-competitive NMDA receptor antagonist
- Blocks NMDA-activated single-channel activity
- Inhibits activation of microglia induced by LPS
- Reduces microglial TNF-α output
- Can be used to induce schizophrenia models
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