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Filtered Search Results
Medchemexpress LLC AZD9496 maleate | ≥95.0% | 2 MG
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AZD9496 maleate is a potent and selective estrogen receptor (ERα) antagonist. It acts as an orally bioavailable selective oestrogen receptor degrader (SERD).
- Potent and selective ERα antagonist
- Orally bioavailable selective oestrogen receptor degrader (SERD)
- IC50 of 0.28 nM
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Medchemexpress LLC Ilginatinib maleate (NS-018 maleate) | 1354799-87-3 | 99.87% | 505.50 | 1 ML
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Ilginatinib maleate (NS-018 maleate) | 1354799-87-3 | 99.87% | 505.50 | 1 ML
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eMolecules 4392-24-9 | 3-Phenyl-2-propenyl bromide | Ambeed197.075 | C9H9Br | 98.000 | BrCC=Cc1ccccc1 | 5g | 525881520
3-Phenyl-2-propenyl bromide | Ambeed | 4392-24-9197.075 | C9H9Br | 98.000 | BrCC=Cc1ccccc1 | 5g | 525881520
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Medchemexpress LLC Trimebutine (maleate) | 34140-59-5 | 99.7% | 1 ML
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Trimebutine (maleate) | 34140-59-5 | 99.7% | 1 ML
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1PLUSCHEM LLC Ingenol mebutate | 75567-37-2 | 430.5 g/mol | 1MG
Ingenol mebutate | 75567-37-2 | 430.5 g/mol | 1MG
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TARGETMOL CHEMICALS INC FLUPIRTINE MALEATE 200MG
Also available in 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Flupirtine maleate (Katadolon maleate) a centrally acting non-opioid analgesia is the salt form of Flupirtine. It is an NMDA receptor antagonist and also a specific neuronal potassium channel opener. purity: 99%
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Medchemexpress LLC Ciproxifan maleate | 184025-19-2 | C20H22N2O6 | 1 ML
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Ciproxifan maleate is a potent, selective, orally bioavailable, and competitive antagonist of the histamine H3-receptor, with an IC50 of 9.2 nM. It shows low apparent affinity at other receptor subtypes and can be used for the research of aging disorders and Alzheimer's disease.
- Inhibits [3H]HA release from synaptosomes of rat cerebral cortex (Ki: 0.5 nM).
- Inhibits binding of [125I]iodoproxyfan with rat striatal membranes (Ki: 0.7 nM).
- Increases t-MeHA level in mouse brain (ED50: 0.14 mg/kg).
- Improves accuracy of responding in five-choice tasks in rats.
- Induces neocortical electroencephalogram activation and waking state in cats.
- Decreases H3-receptor ligand concentration in serum in mice.
- Exhibits oral bioavailability (F=62%) and maximal concentration (Cmax=420 nM) in mice.
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Medchemexpress LLC U-99194 maleate (U-99194A) | 234757-41-6 | 99.2% | 50 MG
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U-99194 (PNU-99194) maleate is a selective and potent dopamine D3 receptor antagonist. It inhibits the activation of D3 receptors mediated by endogenously released dopamine or exogenous D3 agonists. This compound can be used for the study of dopamine D3 receptor-mediated motor disorders, particularly kinetic tremors.
- Selective, potent dopamine D3 receptor antagonist (Ki = 160 nM).
- Inhibits D3 receptor activation.
- Abrogates IPSC-suppressive effect of D3 agonist PD 128907 in rat hippocampal slices.
- Significantly suppresses nicotine-induced tremor in mice.
- Useful for studying dopamine D3 receptor-mediated motor disorders, especially kinetic tremors.
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Medchemexpress LLC Filgotinib (maleate) | 1802998-75-9 | 99.9% | 541.58 | 5 MG
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Filgotinib maleate is a selective, orally available JAK1 inhibitor with anti-inflammatory and antiviral activities. It effectively inhibits JAK1, JAK2, JAK3, and TYK2. It also inhibits HIV-1 driven gene transcription and reduces proliferation of HIV-1 infected cells. It can be used in the study of rheumatoid arthritis and inflammatory bowel disease.
- Inhibits differentiation of Th2 cells and Th1 cells.
- Produces dose-dependent bone damage protection.
- Prevents the development of inflammation in animal models of collagen-induced arthritis.
- Reduces inflammatory cell infiltration.
- Protects articular cartilage and bone.
- Reduces serum levels of inflammatory cytokines and chemokines.
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Ambeed tertButyl propiolate
tert-Butyl propiolate, 13831-03-3, 95%
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Medchemexpress LLC (S)-timolol maleate | 26921-17-5 | MFCD00058356 | 100.0% | 432.49 | C17H28N4O7S | 10 MG
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(S)-Timolol maleate is the S-enantiomer of timolol supplied as the maleate salt and provided as an analytical/research standard for pharmacological testing, method development, and quality control. It is a non-cardioselective, hydrophilic β-adrenoceptor blocker commonly used in research related to intraocular pressure and cardiovascular effects.
- Analytical standard for method development and quality control.
- S-enantiomer maleate salt with defined stereochemistry.
- High purity suitable for HPLC and reference standard use.
- Molecular weight 432.49 and formula C17H28N4O7S.
- Store sealed at 4°C, protected from light and moisture.
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eMolecules 922-67-8 | Methyl propiolate | AA Blocks LLC | MFCD00008572 | 84.074 | C4H4O2 | 0.000 | COC(=O)C#C | 25g | 448665144
Methyl propiolate | AA Blocks LLC | 922-67-8 | MFCD00008572 | 84.074 | C4H4O2 | 0.000 | COC(=O)C#C | 25g | 448665144
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eMolecules 922-67-8 | Methyl propiolate | Oakwood Chemicals | MFCD00008572 | 84.074 | C4H4O2 | 97.000 | COC(=O)C#C | 25g | 480136917
Methyl propiolate | Oakwood Chemicals | 922-67-8 | MFCD00008572 | 84.074 | C4H4O2 | 97.000 | COC(=O)C#C | 25g | 480136917
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Medchemexpress LLC PD-168077 maleate | 190383-31-4 | 334.41 | 25 MG
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PD-168077 maleate is a selective dopamine D4 receptor agonist with a Ki of 9 nM. It is suitable for use in various research applications, including studies on neurological function and signaling pathways, and has shown significant effects in both cellular and in vivo models.
- Activates human dopamine receptor D4, stimulating mitogenesis in D4-transfected CHO pro-5 cells (EC50 of 17 nM).
- Exhibits agonist activity at human D4.4 receptor in HEK293 cells (EC50 of 8.3 nM).
- Induces dose-dependent locomotion and myoclonic jerking in animal models.
- Increases p-CaMKII clustering at synaptic sites, enhancing colocalization with PSD-95.
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Medchemexpress LLC Neratinib maleate | 915942-22-2 | 99.7% | 673.11 | 50 MG
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Neratinib maleate (HKI-272 maleate) is an orally available, irreversible, highly selective HER2 and EGFR inhibitor. It is intended for research use only.
- Inhibits HER2 and EGFR with IC50s of 59 nM and 92 nM, respectively.
- Demonstrates antiproliferative effects in cell lines with high HER-2 levels.
- Arrests cell cycle at G1-S phase in BT474 cells.
- Inhibits MAPK and Akt phosphorylation, and induces p27.
- Exhibits anticancer activities against HER-2 or EGFR expressing cancer cells in vivo.
- Reduces tumor growth in xenograft models.
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