Carboxylic acid esters
Apexbio Technology LLC Menadiol Diacetate 573-20-6 1g
Menadiol Diacetate (CAS 573-20-6) is a synthetic derivative of vitamin K investigated for its regulatory effects on cellular signaling pathways and enzyme activities In experimental studies Menadiol Diacetate has been shown to induce S phase arrest in the cell cycle leading to apoptotic cell death This compound is utilized in research focused on cancer and related diseases providing a tool for exploring mechanisms of cell proliferation and apoptosis in vitro
Medchemexpress LLC Dimethyl fumarate-d6 | 66487-95-4 | 99.9% | 150.16 | 1 MG
Dimethyl fumarate-d6 is a deuterium-labeled Dimethyl fumarate that acts as a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator, leading to the upregulation of antioxidant gene expression. It is intended for research use only and can be used for various analytical purposes.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by techniques such as NMR, GC-MS, or LC-MS
Apexbio Technology LLC Cinepazide maleate 26328-04-1 50mg
Cinepazide maleate (CAS 26328-04-1) is the maleate salt of cinepazide classified as a vasodilatory agent It exerts its effects primarily through inhibition of calcium influx in vascular smooth muscle cells leading to vessel relaxation and increased blood flow This mechanism is associated with reduced peripheral resistance and enhanced microcirculation Cinepazide maleate has been utilized in research exploring vascular tone modulation cerebral blood flow and ischemia models providing a tool for investigating mechanisms of vasodilation and circulatory disorders in preclinical settings
Apexbio Technology LLC Flupirtine maleate 75507-68-5 1g
Flupirtine maleate (CAS 75507-68-5) is a non-opioid analgesic compound characterized by its modulatory effects on neuronal excitability It acts primarily by opening neuronal potassium channels leading to membrane stabilization and reduced excitatory neurotransmission Additionally flupirtine exerts indirect antagonism of N-methyl-D-aspartate (NMDA) receptors which contributes to its analgesic and muscle relaxant effects Due to this dual mechanism flupirtine maleate is utilized in research focusing on pain modulation neuroprotection and the investigation of NMDA receptor-mediated pathways
Apexbio Technology LLC Flupirtine maleate 75507-68-5 10mM (in 1mL DMSO)
Flupirtine maleate (CAS 75507-68-5) is a non-opioid analgesic compound characterized by its modulatory effects on neuronal excitability It acts primarily by opening neuronal potassium channels leading to membrane stabilization and reduced excitatory neurotransmission Additionally flupirtine exerts indirect antagonism of N-methyl-D-aspartate (NMDA) receptors which contributes to its analgesic and muscle relaxant effects Due to this dual mechanism flupirtine maleate is utilized in research focusing on pain modulation neuroprotection and the investigation of NMDA receptor-mediated pathways
Apexbio Technology LLC Flupirtine maleate 75507-68-5 100mg
Flupirtine maleate (CAS 75507-68-5) is a non-opioid analgesic compound characterized by its modulatory effects on neuronal excitability It acts primarily by opening neuronal potassium channels leading to membrane stabilization and reduced excitatory neurotransmission Additionally flupirtine exerts indirect antagonism of N-methyl-D-aspartate (NMDA) receptors which contributes to its analgesic and muscle relaxant effects Due to this dual mechanism flupirtine maleate is utilized in research focusing on pain modulation neuroprotection and the investigation of NMDA receptor-mediated pathways
Apexbio Technology LLC Cinepazide maleate 26328-04-1 10mM (in 1mL DMSO)
Cinepazide maleate (CAS 26328-04-1) is the maleate salt of cinepazide classified as a vasodilatory agent It exerts its effects primarily through inhibition of calcium influx in vascular smooth muscle cells leading to vessel relaxation and increased blood flow This mechanism is associated with reduced peripheral resistance and enhanced microcirculation Cinepazide maleate has been utilized in research exploring vascular tone modulation cerebral blood flow and ischemia models providing a tool for investigating mechanisms of vasodilation and circulatory disorders in preclinical settings
Medchemexpress LLC Neratinib (maleate) | 915942-22-2 | 99.7% | 673.11 | 5 MG
Neratinib maleate is an orally available, irreversible, and highly selective inhibitor of HER2 and EGFR. It effectively inhibits the proliferation of cell lines expressing high levels of HER-2 and shows anticancer activities in tumor xenograft models. This compound induces G1-S phase arrest and leads to inhibition of MAPK and Akt phosphorylation.
- Orally available
- Irreversible, highly selective HER2 and EGFR inhibitor
- Inhibits proliferation of HER-2 expressing cell lines
- Induces G1-S phase arrest
- Inhibits MAPK and Akt phosphorylation
- Shows anticancer activity in tumor xenograft models
Medchemexpress LLC VTP50469 fumarate | 2169919-29-1 | 99.8% | 804.93 | 100 MG
VTP50469 fumarate is a potent, highly selective, and orally active Menin-MLL interaction inhibitor. It demonstrates potent anti-leukemia activity with a Ki of 104 pM.
- Inhibits cell proliferation in MLL-r and ALL cell lines
- Induces apoptosis in MLL-r B cell ALL cell lines
- Causes dose-dependent differentiation in MLL-r AML cell lines
- Displaces Menin from protein complexes and inhibits chromatin occupancy of MLL
- Leads to changes in gene expression, differentiation, and apoptosis
- Shows significant survival advantage in in vivo studies in NSG mice
Apexbio Technology LLC NB-598 Maleate 155294-62-5 5mg
NB-598 Maleate is a small-molecule inhibitor targeting squalene epoxidase (SE) an essential enzyme in cholesterol biosynthesis It is designed to inhibit SE thereby disrupting the oxygenation of squalene and affecting downstream synthesis of cholesterol intermediates particularly within farnesol-dependent pathways leading to triglyceride biosynthesis NB-598 Maleate exerts its biological activity primarily through inhibition of squalene epoxidase In mouse pancreatic islet models NB-598 Maleate reduces insulin secretion under both basal and glucose-stimulated conditions Additionally this compound inhibits calcium voltage-dependent (CaV) ion channels in cellular assays Based on these pharmacological properties NB-598 Maleate holds research potential in studying cholesterol biosynthesis pathways lipid metabolism insulin regulation and the physiological role of CaV channels
Apexbio Technology LLC NB-598 Maleate 155294-62-5 200mg
NB-598 Maleate is a small-molecule inhibitor targeting squalene epoxidase (SE) an essential enzyme in cholesterol biosynthesis It is designed to inhibit SE thereby disrupting the oxygenation of squalene and affecting downstream synthesis of cholesterol intermediates particularly within farnesol-dependent pathways leading to triglyceride biosynthesis NB-598 Maleate exerts its biological activity primarily through inhibition of squalene epoxidase In mouse pancreatic islet models NB-598 Maleate reduces insulin secretion under both basal and glucose-stimulated conditions Additionally this compound inhibits calcium voltage-dependent (CaV) ion channels in cellular assays Based on these pharmacological properties NB-598 Maleate holds research potential in studying cholesterol biosynthesis pathways lipid metabolism insulin regulation and the physiological role of CaV channels
Apexbio Technology LLC NB-598 Maleate 155294-62-5 10mM (in 1mL DMSO)
NB-598 Maleate is a small-molecule inhibitor targeting squalene epoxidase (SE) an essential enzyme in cholesterol biosynthesis It is designed to inhibit SE thereby disrupting the oxygenation of squalene and affecting downstream synthesis of cholesterol intermediates particularly within farnesol-dependent pathways leading to triglyceride biosynthesis NB-598 Maleate exerts its biological activity primarily through inhibition of squalene epoxidase In mouse pancreatic islet models NB-598 Maleate reduces insulin secretion under both basal and glucose-stimulated conditions Additionally this compound inhibits calcium voltage-dependent (CaV) ion channels in cellular assays Based on these pharmacological properties NB-598 Maleate holds research potential in studying cholesterol biosynthesis pathways lipid metabolism insulin regulation and the physiological role of CaV channels
Medchemexpress LLC Pd-168077 maleate | 630117-19-0 | 99.6% | 450.49 | 1 ML
PD-168077 maleate is a selective dopamine D4 receptor agonist with a Ki of 9 nM. It is intended for research use only. It exhibits intrinsic activity at the D4 receptor, leading to quinpirole-like inhibition of forskolin-stimulated cAMP accumulation or stimulation of [3H]thymidine uptake.
- Shows >100-fold selectivity over other D2-like receptor family members and D1-like counterparts.
- Demonstrates 20-fold selectivity over α1 and α2 receptors.
- Exhibits 45-fold selectivity over 5-HT1A.
- Shows 460-fold selectivity over 5-HT2A receptors.
- Induces synaptic translocation of Ca2+/calmodulin-dependent protein kinase II in cultured prefrontal cortical neurons.
Medchemexpress LLC Dbm-mmaf | 1810001-93-4 | 99.7% | 1082.95 g/mol | C49H74Br2N6O11 | 10 MG
DBM-MMAF is a drug-linker conjugate that couples the antitubulin payload monomethyl auristatin F (MMAF) to a DBM linker for use in antibody-drug conjugate (ADC) research. It is supplied as a solid with high purity and is intended for preclinical and research applications.
- Agent-linker conjugate designed for ADC research.
- Purity: 99.65% as provided by manufacturer.
- Solid form; soluble in DMSO at 200 mg/mL.
- Molecular formula C49H74Br2N6O11; molecular weight 1082.95 g/mol.
- Recommended storage: 4°C, protect from light; in solvent store at -80°C for 6 months or -20°C for 1 month.
- Available in small milligram amounts suitable for lead generation and conjugation optimization.
Apexbio Technology LLC NB-598 Maleate 155294-62-5 50mg
NB-598 Maleate is a small-molecule inhibitor targeting squalene epoxidase (SE) an essential enzyme in cholesterol biosynthesis It is designed to inhibit SE thereby disrupting the oxygenation of squalene and affecting downstream synthesis of cholesterol intermediates particularly within farnesol-dependent pathways leading to triglyceride biosynthesis NB-598 Maleate exerts its biological activity primarily through inhibition of squalene epoxidase In mouse pancreatic islet models NB-598 Maleate reduces insulin secretion under both basal and glucose-stimulated conditions Additionally this compound inhibits calcium voltage-dependent (CaV) ion channels in cellular assays Based on these pharmacological properties NB-598 Maleate holds research potential in studying cholesterol biosynthesis pathways lipid metabolism insulin regulation and the physiological role of CaV channels
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