Dicarboxylic acids and derivatives
Apexbio Technology LLC GlyH-101 328541-79-3 50mg
GlyH-101 (CAS 328541-79-3) is a cell-permeable glycinyl hydrazone derivative that acts as a selective inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel exhibiting a Ki of 1 4 M By blocking CFTR-mediated chloride transport GlyH-101 serves as a valuable tool for investigating CFTR function in epithelial physiology and pathophysiology as well as for studying mechanisms underlying cystic fibrosis and related disorders involving chloride ion dysregulation
Medchemexpress LLC AVN-101 hydrochlorid 25mg | 1061354-48-0 | 340.89 | C21H25ClN2 | 25 MG
AVN-101 hydrochloride is the hydrochloride salt of a brain-penetrant small molecule antagonist of serotonin (5-HT) receptors, supplied for preclinical and in-vitro research. It is provided as a solid with reported high purity for analytical and biological assays.
- Potent antagonist of 5-HT receptor subtypes (5-HT7, 5-HT6, 5-HT2A, 5-HT2C).
- High purity: 99.59%.
- Molecular formula C21H25ClN2; molecular weight 340.89.
- Available in small research pack sizes, including 25 MG.
- Provided as hydrochloride salt to improve solubility for assay preparation.
- For research use only; not for human or veterinary use.
Medchemexpress LLC UK-101 | 1000313-40-5 | 99.6% | 484.74 g/mol | 50 MG
UK-101 is a potent, selective inhibitor of the immunoproteasome β1i (LMP2) subunit, commonly used in proteasome biology and cancer research to study apoptosis and proteasome-mediated pathways.
- Potent LMP2 inhibition with an IC50 of about 104 nM.
- Demonstrates high selectivity versus related proteasome subunits for target-specific studies.
- Induces cell apoptosis, useful in cancer biology assays.
- High purity (≈99.6%) for reproducible experimental results.
- Soluble in DMSO (≈7.3 mg/mL) for easy stock preparation.
- Stable as a powder under low-temperature storage for long-term use.
- Provided in a small research pack suitable for laboratory assays.
Medchemexpress LLC VNT-101 | 2894060-67-2 | 99.5% | 456.41 | 5 MG
VNT-101 is an orally active influenza A (IAV) inhibitor that disrupts NP-NP PPI to block NP oligomerization and destabilize the viral ribonucleoprotein (RNP) complex. It exhibits potent antiviral activity across multiple influenza A subtypes and robust in vivo antiviral efficacy in mice infected with lethal H1N1 virus. It can be used for the study of influenza A infection.
- Orally active influenza A (IAV) inhibitor.
- Disrupts NP-NP PPI to block NP oligomerization.
- Destabilizes the viral ribonucleoprotein (RNP) complex.
- Potent antiviral activity across multiple influenza A subtypes.
- Exhibits EC50 values of 4-5 nM in cellular cytopathic effect (CPE) assay, 4-8 nM in neuraminidase (NA) assay, and 21-45 nM in RNP assay.
- Demonstrates robust in vivo antiviral efficacy in mice infected with lethal H1N1 virus.
Medchemexpress LLC Sulforhodamine 101 DHPE | 187099-99-6 | >95.0% | 1381.84 | C74H117N4O14PS2 | 1MG
Sulforhodamine 101 DHPE is a red fluorescent phospholipid probe created by conjugating dipalmitoyl phosphoethanolamine to sulforhodamine 101. It readily incorporates into lipid bilayers and is used for membrane imaging, monitoring probe colocalization in liposomes, and detecting protein-ligand interactions on supported bilayers. The dye exhibits excitation/emission peaks near 586/605 nm and is supplied as a powder with recommended cold storage.
Medchemexpress LLC GlyH-101 | 328541-79-3 | 99.7% | 493.15 | 5 MG
GlyH-101 is a potent inhibitor of CFTR (Cystic Fibrosis Transmembrane conductance Regulator) and VSORC (Volume-Sensitive Outwardly Rectifying Chloride) conductance. It exhibits antiproliferative activity by inhibiting CFTR-like and VSORC currents and is intended for research use only.
- Potent CFTR inhibitor
- Potent and reversible VSORC inhibitor
- Exhibits antiproliferative activity in PCT and PS120 cells
- Inhibits CFTR-like current in PCT cells
- Inhibits VSORC current in PS120 and PCT cells
- Reduces cholera toxin-induced intestinal fluid secretion in mice
- Available as a solid, light yellow to yellow
- Soluble in DMSO
![Medchemexpress LLC 3-Pyridinecarboxamide, 1,2-dihydro-5-[4-[[(2S,6S)-6-(methoxymethyl)-6-methyl-1,4-dioxan-2-yl]methoxy]phenyl]-2-oxo-6-(trifluoromethyl)- | 2894060-67-2 | 99.5% | 456.41 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000383955-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 3-Pyridinecarboxamide, 1,2-dihydro-5-[4-[[(2S,6S)-6-(methoxymethyl)-6-methyl-1,4-dioxan-2-yl]methoxy]phenyl]-2-oxo-6-(trifluoromethyl)- | 2894060-67-2 | 99.5% | 456.41 | 25 MG
3-Pyridinecarboxamide, 1,2-dihydro-5-[4-[[(2S,6S)-6-(methoxymethyl)-6-methyl-1,4-dioxan-2-yl]methoxy]phenyl]-2-oxo-6-(trifluoromethyl)- | 2894060-67-2 | 99.5% | 456.41 | 25 MG
Medchemexpress LLC ULK-101 100mg | 2443816-45-1 | 100 MG
ULK-101 is a potent and selective ULK1 inhibitor used in research to suppress autophagy and sensitize cancer cells to nutrient stress. It demonstrates high potency against ULK1 with reduced activity against ULK2.
- Selective ULK1 inhibition with IC50 ≈ 1.6 nM.
- Reduced activity against ULK2 (IC50 ≈ 30 nM).
- High chemical purity reported at 99.91%.
- Molecular formula C22H16F4N4OS and molecular weight 460.45.
- Supplied as a powder; common pack size 100 mg.
- Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (2 years) or -20°C (1 year).
![Medchemexpress LLC Benzyl 3-[6-[[2-(butylamino)-1-[3-methoxycarbonyl-4-(2-methoxy-2-oxoethoxy)phenyl] | 831217-40-4 | 98.2% | 931.12 g/mol | C54H66N4O10 | 1MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000238871.png-250.jpg)
Medchemexpress LLC Benzyl 3-[6-[[2-(butylamino)-1-[3-methoxycarbonyl-4-(2-methoxy-2-oxoethoxy)phenyl] | 831217-40-4 | 98.2% | 931.12 g/mol | C54H66N4O10 | 1MG
MAL3-101 is a small-molecule allosteric inhibitor of heat shock protein 70 (HSP70) used in cellular and biochemical research. It inhibits HSP70 ATPase activity by blocking interaction with Hsp40 co-chaperones, perturbing protein folding and proteostasis pathways. The compound is supplied as a high-purity research reagent (CAS 831217-40-4) and is intended for in vitro and preclinical studies only.
- Allosteric inhibitor of HSP70 ATPase activity.
- Blocks Hsp40-Hsp70 interaction to disrupt protein folding.
- Applicable to cellular models studying proteostasis and cancer biology.
- High reported purity supports reproducible results.
- Supplied in small quantities suitable for screening and pilot studies.
- For research use only; not for human or veterinary use.
Selleck Chemical LLC PHI-101-E1437-25MG
PHI-101 is an orally active potent third-generation inhibitor of FLT3 that overcomes resistance to multiple drug-resistant mutations It has potential for research in relapsed or refractory acute myeloid leukemia (AML)
Selleck Chemical LLC NLX-101 S3510-5mg
NLX-101 (F-15599) is a highly selective 5-HT1A receptor biased agonist that mediates antidepressant-like activity in rats via prefrontal cortex 5-HT 1A receptors
Selleck Chemical LLC MZ-101-E1913-25MG
MZ-101 (GYS1-IN-2) is a potent small molecule inhibitor of Glycogen synthase 1(GYS1) with an IC50 value of 0 041 M By depleting muscle glycogen MZ-101 treatment normalizes glycogen levels and corrects transcriptional and metabolic abnormalities in Pompe mice