Dicarboxylic acids and derivatives
Medchemexpress LLC UCPH-101 excitatory amino acid transporter subtype 1 inhibitor | 1118460-77-7 | 98.6% | 422.48 | 1 ML
UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM. This compound is suitable for research applications. It presents as a white to off-white solid.
- Molecular weight: 422.48
- Formula: C27H22N2O3
- Appearance: Solid
- Color: White to off-white
- Shipping: Room temperature in continental US (may vary elsewhere)
- Storage: Powder at -20°C for 3 years or 4°C for 2 years; in solvent at -80°C for 2 years or -20°C for 1 year
- Solubility: In DMSO: ≥ 50 mg/mL (118.35 mM)
Medchemexpress LLC UCPH-101 | 1118460-77-7 | 98.6% | 422.48 | 10 MG
UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM. It functions as an allosteric modulator, inducing sustained inhibition of EAAT1 through an intramonomeric site within the trimerization domain. In vitro studies show that UCPH-101 inhibits EAAT1 anion currents in a concentration-dependent manner, with a KD value of 0.34±0.03 μM. This compound is intended for research use only.
- Inhibits excitatory amino acid transporter subtype 1 (EAAT1)
- Functions as an allosteric modulator
- Demonstrates sustained inhibition of EAAT1 anion currents
- IC50 of 0.66 μM
- KD value of 0.34±0.03 μM for EAAT1 anion currents
Apexbio Technology LLC CAL-101 (Idelalisib, GS-1101) 870281-82-6 50mg
CAL-101 (Idelalisib GS-1101 CAS 870281-82-6) is a selective inhibitor targeting the p110 isoform of phosphatidylinositol 3-kinase (PI3K) an enzyme involved in signaling pathways critical for proliferation and survival of malignant B cells By inhibiting PI3K p110 CAL-101 reduces PI3K-mediated phosphorylation of Akt and other downstream factors leading to enhanced PARP cleavage and caspase activation ultimately inducing apoptosis in malignant B cells CAL-101 has been demonstrated to counteract survival signals initiated by molecules such as CD40 ligand (CD40L) TNF- and fibronectin This agent is valuable in investigating B-cell malignancies
Medchemexpress LLC 1,2-dilauroyl-sn-glycero-3-phosphoethanolamine | 59752-57-7 | MFCD00042828 | 98.0% | 579.75 g·mol⁻¹ | C29H58NO8P | 100 MG
1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine (DLPE) is a phosphatidylethanolamine derivative bearing two lauroyl (C12:0) acyl chains. It is a research-grade lipid commonly used for liposome formulation and membrane model studies; typical properties include a molecular weight of 579.75 g·mol⁻¹ and high purity (98.0%).
- Phosphatidylethanolamine lipid with two lauroyl (C12:0) chains.
- Suitable for liposome synthesis and membrane model studies.
- High purity (98.0%) for research applications.
- Molecular formula C29H58NO8P and molecular weight 579.75 g·mol⁻¹.
Medchemexpress LLC GlyH-101 | 328541-79-3 | 99.7% | 493.15 | 25 MG
GlyH-101 is a potent and reversible inhibitor of CFTR (Cystic Fibrosis Transmembrane conductance Regulator) and VSORC (Volume-Sensitive Outwardly Rectifying Chloride) conductance. It also exhibits antiproliferative activity by inhibiting cell growth in a dose-dependent manner. This compound is suitable for various in vitro and in vivo studies related to cystic fibrosis and other conditions involving chloride channel regulation.
- Potent CFTR inhibitor
- Reversible inhibitor of VSORC conductance
- Exhibits antiproliferative activity in PCT and PS120 cells
- Reduces cholera toxin-induced intestinal fluid secretion in mice
- Soluble in DMSO for in vitro applications
- Available in various solid quantities
TARGETMOL CHEMICALS INC CUDC-101 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. CUDC-101 is a potent inhibitor of HDAC EGFR and HER2 with IC50s of 4.4 2.4 and 15.7 nM respectively. purity: 99%
