Tricarboxylic acids and derivatives
Medchemexpress LLC Enclomiphene citrate | 7599-79-3 | 99.9% | 598.09 | C32H36ClNO8 | 1 ML
Enclomiphene citrate is a research-grade, non-steroidal estrogen receptor antagonist supplied as a solid or as a ready-to-use 10 mM solution in DMSO for in vitro and in vivo studies.
- High purity typically 99.93%.
- Available as a 10 mM solution (1 mL) in DMSO or as mg-scale solids.
- Used for studies of ovarian dysfunction, testosterone deficiency, and male hypogonadism.
- Molecular weight 598.09, formula C32H36ClNO8, CAS 7599-79-3.
- Store powder at 4°C; stock solutions at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC MRTX9768 | 2629314-68-5 | 99.48% | 424.43 | 50 MG
MRTX9768 is a potent, selective, orally active, first-in-class PRMT5-MTA complex inhibitor. It inhibits SDMA and cell proliferation in HCT116 MTAP-del cells with marked selectivity over HCT116 MTAP-WT cells. This compound selectively targets MTAP/CDKN2A-deleted tumors, such as glioblastoma, and exhibits a favorable ADME profile.
- Potent and selective PRMT5-MTA complex inhibitor
- Inhibits SDMA and cell proliferation in MTAP-del cells
- Demonstrates dose-dependent inhibition of SDMA in MTAP-del tumors
- Selectively targets MTAP/CDKN2A-deleted tumors, including glioblastoma
- Favorable ADME profile with high bioavailability and moderate to high clearance
Medchemexpress LLC Tos-PEG3-CH2COOH | 1581248-63-6 | C15H22O8S | 10MG
Tos-PEG3-CH2COOH is a PEG-based PROTAC linker with a tosyl cap and a three-unit polyethylene glycol spacer terminating in a carboxylic acid. It is designed for use in the synthesis of PROTACs and other bifunctional molecules where a short, flexible, polar spacer and a carboxyl functional handle are required.
- Tosyl-capped PEG3 spacer ending in a carboxylic acid for conjugation.
- Provides a short, flexible, hydrophilic linker suitable for cellular applications.
- Terminal carboxyl group enables amide or ester coupling chemistries.
- Compatible with solid-phase and solution-phase synthetic workflows.
- Supplied in research-scale quantities for medicinal chemistry and PROTAC development.
- Molecular formula C15H22O8S, molecular weight ≈362.40 g/mol.
Selleck Chemical LLC Orphenadrine Citrate S2054-50mg
Orphenadrine Citrate is a skeletal muscle relaxant it acts in the central nervous system to produce its muscle relaxant effects
Medchemexpress LLC ARL67156 trisodium hydrate | MFCD12910436 | 99.9% | 834.61 g/mol | C15H23Br2N5Na3O13P3 | 1 MG
ARL67156 trisodium hydrate is the trisodium salt hydrate form of ARL67156 (FPL 67156), a small-molecule inhibitor of ecto-ATPases used in research to study extracellular ATP signaling and disease models such as calcific aortic valve disease and asthma.
- Inhibits ecto-ATPase enzymes, including NTPDase1 (CD39), NTPDase3, and NPP1.
- Reported Ki values: 11 μM, 18 μM, and 12 μM for NTPDase1, NTPDase3, and NPP1, respectively.
- Purity 99.94% as reported on the product page.
- Supplied as a trisodium hydrate salt.
- Available in small research quantities (for example, 1 mg and 5 mg sizes).
Medchemexpress LLC 5,8,11,14,17,20-hexaoxa-2-azadocosanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester | 437655-96-4 | 99.4% | 561.62 | C29H39NO10 | 250 MG
Fmoc-NH-PEG6-CH2COOH is an Fmoc-protected polyethylene glycol (PEG6) linker with a terminal carboxylic acid, supplied for research use as a cleavable linker for antibody-drug conjugates and as a PEG-based PROTAC linker in targeted protein degradation research.
- Fmoc-protected amine with terminal carboxylic acid functionality.
- Suitable for ADC and PROTAC linker synthesis.
- Reported purity 99.4% and molecular weight 561.62.
- Molecular formula C29H39NO10.
- Available in small-scale pack sizes including 250 MG.
Medchemexpress LLC Amino-PEG3-CH2COOH | 134978-99-7 | 99.9% | C8H17NO5 | 100 MG
Amino-PEG3-CH2COOH is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker, with one targeting an E3 ubiquitin ligase and the other targeting the protein of interest. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Mosapride citrate | 112885-42-4 | 99.96% | 5 MG
Mosapride citrate is an orally active gastroenterokinetic compound, acting as a 5HT4 agonist and a CYP inducer. It demonstrates a concentration-dependent inhibitory effect on Kv4.3 with an IC50 value of 15.2 μM. This compound is suitable for use in the study of gastrointestinal diseases.
- Acts as a 5HT4 agonist
- Functions as a CYP inducer
- Exhibits concentration-dependent inhibitory effect on Kv4.3 with an IC50 of 15.2 μM
- Promotes gastric emptying
- Relieves NSAID-induced ulcers by activating the 5-HT4 receptor
Medchemexpress LLC Fmoc-NH-PEG6-CH2COOH | 437655-96-4 | 99.4% | 5 G
Fmoc-NH-PEG6-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. This compound leverages the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- Cleavable ADC linker
- PEG-based PROTAC linker
- Utilized in antibody-drug conjugate (ADC) synthesis
- Used in PROTAC synthesis
- Leverages intracellular ubiquitin-proteasome system
Medchemexpress LLC Mosapride citrate | 112885-42-4 | 99.9% | 1 ML
Mosapride citrate is an orally active gastroenterokinetic compound. It acts as a 5HT4 agonist and a CYP inducer. It exhibits a concentration-dependent inhibitory effect on Kv4.3, with an IC50 value of 15.2 μM. Mosapride citrate is used in the study of gastrointestinal diseases.
- Orally active gastroenterokinetic compound
- 5HT4 agonist
- CYP inducer
- Inhibitory effect on Kv4.3
- Useful for studying gastrointestinal diseases