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Agarose and acrylamide powders, buffers, diluents, markers and stains for protein/nucleic acid electrophoresis; featuring concentration, grade, melting point, capacity to stabilize, control concentration, denature, reduce, and mark target molecules.
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A multivalent ionizable cationic lipid has been used in the generation of liposomes complexed with plasmid DNA for use in vitro and in vivo has been used in combination with DC-Chol and 12-DOPE in the generation of lipid nanocarriers for siRNA delivery to A549 cells GL67-containing liposomes in complex with plasmid DNA for the gene encoding CFTR leads to the expression of functional wild-type CFTR in HEK293 cells aerosol administration of GL67-containing liposomes in complex with plasmid DNA for the gene encoding CFTR increases trachea and whole lung mRNA levels of CFTR
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The 15 kb DNA Marker is supplied in a 1x DNA Loading Buffer solution, allowing for direct use in nucleic acid electrophoresis analysis. This marker includes 8 double-stranded DNA fragments that range in size from 500 bp to 15 kb. A 5 μL aliquot of this product contains approximately 80 ng for the 4000 bp band and around 30 ng for the other bands.
Provided in a solution of 1x DNA loading buffer.
Can be directly used for nucleic acid electrophoresis analysis.
Contains 8 double-stranded DNA fragments ranging from 500 bp to 15 kb.
A 5 μL quantity of this product provides about 80 ng for the 4000 bp band and about 30 ng for the remaining bands.
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A synthetic peptide corresponding to the nuclear localization sequence of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells; blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α
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The DL15000 DNA Marker is a ready-to-use DNA Marker, which is pre-mixed with loading dye for direct gelloading. This product consists of 7 individual DNA fragments: 250 bp, 1000 bp, 2500 bp, 5000 bp, 7500 bp, 10000 bp and 15000 bp derived from amixture of PCR products and specifically digested plasmid DNA.
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Hyperladder,200 lanes,12 bands, ranging from 25 to 500 bp,each band is an exact multiple of 25 bp and contains an exact amount of dsDNA, for DNA Size Determination and Quantification
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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
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A Cdk9 inhibitor (IC50 = 6 nM); selective for Cdk9 over Cdk1-8 (IC50s = 397->10,000 nM) and Cdk12-19 (IC50s = 372->10,000 nM); induces cell cycle arrest at the G1 phase and apoptosis in BT-20, BT-549, MDA-MB-231, MT-3, and Hs 578T TNBC cells from 0.64-7.73 µM; reduces tumor volume in the MYC-amplified CTG-0437 PDX mouse model of TNBC at 60 mg/kg
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AMPIGENE DNA Ladder 100-10,000 bp contains DNA fragments ranging from 100bp to 10,000bp that can be used as molecular weight standards for agarose gel electrophoresis. The bands are evenly spaced and are intensified at 500bp, 1,500bp and 3,000 to serve as easily identifiable reference bands. The approximate mass of DNA in each of the bands is provided, assuming 5µl load, for determining the approximate mass of DNA in samples with comparable intensity and size. Long Term Storage: -20°C.
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