Oligonucleotides
Cayman Chemical Bax Chnl Blocker 50mg
A Bax inhibitor; binds to Bax in a cell-free assay (Kd = 15 µM); inhibits tBID-induced Bax-mediated membrane permeabilization in a liposomal release assay (IC50 = 3.3 µM); inhibits TNF-α- and cycloheximide-induced apoptosis in MEFs (IC50 = 1.8 µM); inhibits BTSA1-induced cell death in OCI-AML-3 cells
Cayman Chemical 5 Z 8 ZTetradecadIenoIc Ac
An internal standard for the quantification of 5(Z),8(Z)-tetradecadienoic acid by GC- or LC-MS
Alkali Scientific Phosphate Buffered Water (PBW) w/MgCl2 9mL Fliptop Conical Tube, 10/Pk
Phosphate Buffered Water (PBW) with Magnesium Chloride is a sterile diluent widely used in food microbiology and water testing for the preparation of microbial samples. Often referred to as Butterfield’s Buffer, it is recommended by organizations such as the APHA and FDA for enumeration procedures. The phosphate buffer maintains a stable pH while preventing osmotic stress that can damage sensitive microorganisms. The addition of magnesium chloride helps stabilize bacterial cell membranes and improves recovery of thermally injured or environmentally stressed organisms during dilution steps. The 9 mL flip top conical tube format is designed for convenient handling in high throughput laboratories, allowing technicians to quickly perform standardized 1:10 serial dilutions while maintaining accurate microbial recovery.
American Research Products Inc Mouse TGFb1 ELISA Kit
This Mouse Transforming Growth Factor Beta 1 (TGFb1) ELISA Kit is a precoated Sandwich ELISA assay designed to detect and quantify the target analyte in serum platelet-poor plasma tissue homogenates cell culture supernatants and other biological fluids This product is for Research Use Only
ABclonal Technology SPARC Rabbit pAb
This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene.
LifeSensors Cereblon/DDB1/Cul4A/Rbx1 Complex 50µg
The Cereblon (CRBN) complex is an E3 ubiquitin ligase that drives ubiquitination and proteasomal degradation of target proteins. CRBN may also influence memory and learning through interactions with KCTN1. It is widely used in PROTAC drug design and protein degradation studies, where CRBN functions as a substrate adaptor that provides specificity without catalytic activity. CRBN associates with DDB1, Cul4A, and RBX1 to form an active CRBN‑DCX E3 ligase, in which Cullin‑RBX catalyzes ubiquitin transfer from the E2 enzyme to substrates. This complex is validated for enzymatic ubiquitination assays, PROTAC‑mediated ubiquitination studies, and biophysical or HTRF assays analyzing ternary complex formation. Additionally, its FLAG‑tagged components make it suitable for pulldown assays.
Biotium pS2(TFF1/1091), CF594 conjugate, 0.1mg/mL
This antibody recognizes a polypeptide of 6.5 kDa, identified as pS2 estrogen-regulated protein. Its epitope is located in the c-terminus of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased
Medchemexpress LLC sEH inhibitor-1 (compound TCPU) | 1208549-68-1 | 99.6% | 10 MG
sEH inhibitor-1 (TCPU) is a potent, orally active inhibitor of soluble epoxide hydrolase (sEH) with low-nanomolar potency in human and murine assays. It is supplied as a high-purity research-grade compound for biochemical and pharmacological studies.
- Low-nanomolar potency (human IC50 0.4 nM; murine IC50 5.3 nM).
- Molecular formula C17H20F3N3O3 and molecular weight 371.35 g/mol.
- High purity suitable for research (99.62%).
- Available in small milligram pack sizes for in vitro and in vivo experiments.
- Targets soluble epoxide hydrolase for mechanistic and pharmacological studies.
ABclonal Technology Phospho-PTEN-S380 Rabbit pAb
This gene encodes a tumor suppressor protein that functions as a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin-like domain and a catalytic domain similar to dual specificity protein tyrosine phosphatases, but specifically dephosphorylates phosphoinositides. By regulating phosphatidylinositol-3,4,5-trisphosphate levels, it negatively controls the AKT/PKB signaling pathway. A non-canonical upstream initiation site produces a longer isoform associated with the mitochondrial inner membrane, potentially involved in energy metabolism regulation. A pseudogene of this gene is located on chromosome 9. Alternative splicing and multiple translation start sites result in various isoforms.
Cayman Chemical 1113 14dIhydro15keto Pro 100ug
An internal standard for the quantification of 11β-13,14-dihydro-15-keto PGF2α by GC- or LC-MS
Biotium SOX9 / SRY-box 9(SOX9/3141R), CF405S conjugate, 0.1mg/mL
Sox genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. SOX9 plays an important role in the normal skeletal development. It may regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye col
Medchemexpress LLC Cxcr3 protein, human (cell-free, C-His tag) | >80.0% | 10UG
Recombinant human C-X-C chemokine receptor 3 (CXCR3) protein with a C-terminal His tag, expressed in Escherichia coli and provided as a purified recombinant reagent for research use. The sequence corresponds to UniProt P49682 (368 amino acids, ~40,660 Da). Certificate of analysis reports purity greater than 80% by reducing SDS-PAGE.
- Recombinant full-length human CXCR3 expressed in E. coli.
- C-terminal His tag for affinity purification and detection.
- Sequence identity referenced to UniProt accession P49682.
- Purity greater than 80% as determined by reducing SDS-PAGE.
- Intended for research use only.
Biotium SOX9 / SRY-box 9 (PCRP-SOX9-1A2), CF488A conjugate, 0.1mg/mL
The specificity of this monoclonal antibody to its intended target was validated by HuProt™ Array, containing more than 19,000, full-length human proteins. Sox genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. SOX9 plays an important role in the normal skeletal development. It may regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are n
Medchemexpress LLC Tak1 protein, human (Sf9) | ≥98.0% | 20UG
Recombinant human TAK1 protein produced in Sf9 insect cells, supplied as a tag-free, highly purified preparation suitable for biochemical assays, kinase activity studies, and antibody validation. Provided in small-scale quantities; aliquot and store frozen to preserve activity.
- Tag-free recombinant human TAK1 protein.
- Expressed in Sf9 insect cells for eukaryotic post-translational modifications.
- High purity suitable for biochemical and cell-based assays.
- Low endotoxin level for sensitive applications.
- Supplied at a concentration that facilitates small-volume assays.
- Stable when stored at -80°C; avoid repeated freeze-thaw cycles.
Medchemexpress LLC Von Hippel-Lindau protein (human) | >90.0% | 10 UG
Recombinant full-length human von Hippel-Lindau (VHL) protein with an N-terminal 6xHis tag, supplied as a lyophilized powder for research applications. The protein corresponds to residues M1-D213 (Accession P40337), is expressed in E. coli, and is provided with low endotoxin and high purity suitable for biochemical and binding assays.
- Source organism: human.
- Sequence length: full length (M1-D213).
- Tag: N-terminal 6xHis for affinity purification.
- Expression system: E. coli.
- Purity: >90.0% by reducing SDS-PAGE.
- Molecular weight: ~34 kDa.
- Endotoxin: <1 EU/μg.
- Appearance and formulation: lyophilized powder with trehalose-containing buffer.
- Storage and reconstitution: store lyophilized at -20°C; do not reconstitute below 100 μg/mL in ddH2O; freeze aliquots for long-term storage.