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Oligonucleotides with a wide variety of applications in microarrays, gel shift assays, artificial gene synthesis, PCR, DNA sequencing, molecular cloning, and other custom procedures. Available in multiple primer lengths; may be pre-designed or random.
For the rapid purification of amplified DNA products from PCR mixes Purify amplified DNA ranging from 100 bp -15,000bp in size; Fast and efficient spin column format. FEATURES AND BENEFITS Fast and easy processing - Rapid spin-column fo...
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tumor protein p53 binding protein fragment is a protein fragment derived from Homo sapiens and Mus musculus that interacts with the central DNA-binding domain of tumor protein p53 It is designed to modulate p53-dependent transcriptional activation thereby influencing DNA damage response pathways tumor protein p53 binding protein fragment exerts its biological activity by participating in the cellular DNA damage response network particularly through ATM-dependent phosphorylation and localization to DNA damage foci following double-strand breaks Based on these properties tumor protein p53 binding protein fragment holds research potential in studying DNA damage signaling genomic stability and tumorigenesis mechanisms
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This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family HMG proteins function as architectural factors and are essential components of the enhancesome This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor Identification of the deletion amplification and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity Alternate transcriptional splice variants encoding different isoforms have been characterized
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This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells and is found on the surface of thymocytes T lymphocytes monocytes granulocytes and some B lymphocytes It contains a mucin-like extracellular domain a transmembrane region and a carboxy-terminal intracellular region The extracellular domain has a high proportion of serine and threonine residues allowing extensive O-glycosylation and has one potential N-glycosylation site while the carboxy-terminal region has potential phosphorylation sites that may mediate transduction of activation signals Different glycoforms of this protein have been described In stimulated immune cells proteolytic cleavage of the extracellular domain occurs in some cell types releasing a soluble extracellular fragment Defects in expression of this gene are associated with Wiskott-Aldrich syndrome
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