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Filtered Search Results
Chem-Impex International, Inc. Cefotaxime sodium salt | 64485-93-4 | MFCD00079073 | 5G
Cefotaxime sodium salt, 64485-93-4, MFCD00079073, 5G
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Apexbio Technology LLC PD173955 260415-63-2 5mg
PD173955 (CAS 260415-63-2) is a small-molecule inhibitor targeting Bcr-Abl Src and Yes tyrosine kinases with reported IC50 values of 1 2 nM 300 nM and 175 nM respectively Bcr-Abl is associated with oncogenic transformation while Src and Yes are implicated in tumor cell survival proliferation and invasion In cellular assays PD173955 inhibits KL-dependent proliferation of CML CD34 progenitor cells (IC50 50 nM) and reduces G2-M phase cell populations accompanied by an increase in G1 phase cells In HT29 and Bcr-Abl-dependent cell lines PD173955 suppresses proliferation and Src autophosphorylation This compound is widely used in studies investigating kinase signaling and cell cycle regulation in cancer research
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Selleck Chemical LLC Daporinad (FK866) S2799-25mg
Daporinad (FK866) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase Nampt) with IC50 of 0 09 nM in a cell-free assay Daporinad (FK866 APO866) triggers autophagy Phase 1/2
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Medchemexpress LLC VU0155041 | 1093757-42-6 | 99.10% | C14H15Cl2NO3 | 100 MG
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VU0155041 is a potent and selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM for human mGluR4 and 693 nM for rat mGluR4. It has potential for the research of Parkinson's disease (PD).
- Potent, selective positive allosteric modulator (PAM) of mGluR4
- EC50s of 798 nM (human mGluR4) and 693 nM (rat mGluR4)
- Does not affect NMDA receptor currents in striatal medium spiny neurons
- Reverses catalepsy induced by Haloperidol in rats
- Reverses Reserpine-induced akinesia in rats
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Selleck Chemical LLC Ki16425 S1315-2mg
Ki16425 is a competitive potent and reversible antagonist to LPA1 LPA2 and LPA3 with Ki of 0 34 M 6 5 M and 0 93 M in RH7777 cell lines respectively shows no activity at LPA4 LPA5 LPA6
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Medchemexpress LLC HY-10844 100mg , PA-824 Pretomanid;(S)-PA 824 CAS:187235-37-6 Purity:98%
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Medchemexpress, HY-10844 100mg PA-824 Pretomanid;(S)-PA 824 CAS:187235-37-6 Formula:C14H12F3N3O5 Purity:98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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eMolecules 7497-07-6 | Medchem Express | NSC 405020 | 10mg | 446266720 | HY-15827 | MFCD02006898 | 260.16 | C12H15Cl2NO
Medchem Express | NSC 405020 | 10mg | 446266720 | HY-15827 | 7497-07-6 | MFCD02006898 | 260.160 | C12H15Cl2NO
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Research Products International Corp Thiamphenicol, 5 G
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Thiamphenicol is a compound which plays a pivotal role in the study of bacterial infections and the development of antibiotic therapies.
In microbiology, Thiamphenicol is a valuable tool for investigating bacterial susceptibility and resistance patterns. It serves as a reference standard for assessing the effectiveness of antibiotics against various bacterial strains, shedding light on the mechanisms underlying antibiotic resistance. This research deepens our understanding of microbial biology and informs strategies for combating bacterial infections.
Pharmaceutical researchers rely on Thiamphenicol to develop and optimize antibacterial therapies. Its use in testing and formulation contributes to the fight against antibiotic-resistant bacteria, a growing concern in the field of medicine.
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Medchemexpress LLC HY-13945 10mg Medchemexpress, NVP 231 CAS:362003-83-6 Purity:>98%
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Medchemexpress, HY-13945 10mg NVP 231 CAS:362003-83-6 NVP 231 is a potent, specific, and reversible ceramide kinase (CerK) inhibitor(IC50=12 nM) that competitively inhibits binding of ceramide to CerK. NVP 231 induces cell apoptosis by increasing DNA fragmentation and caspase-3 and caspase-9 cleavage. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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eMolecules 1160514-60-2 | Medchem Express | Pyr3 | 5mg | 446259346 | HY-108465 | MFCD00178741 | 456.63 | C16H11Cl3F3N3O3
Medchem Express | MK-3903 | 5mg | 446259221 | HY-107988 | 1219737-12-8 | 454.910 | C27H19ClN2O3
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Medchemexpress LLC HY-13919 5mg Medchemexpress, Napabucasin CAS:83280-65-3 Purity:>98%
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Medchemexpress, HY-13919 5mg Napabucasin CAS:83280-65-3 Napabucasin is a STAT3 inhibitor which blocks stem cell activity in cancer cells. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC Methanone, (4-amino-2-((1R,2R,4S)-bicyclo(2.2.1)hept-2-ylamino)-5-thiazolyl)(2-nitrophenyl)-, rel- | 2237942-08-2 | 98.9% | 25MG
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Methanone, (4-amino-2-((1R,2R,4S)-bicyclo(2.2.1)hept-2-ylamino)-5-thiazolyl)(2-nitrophenyl)-, rel- | 2237942-08-2 | 98.9% | 25MG
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Apexbio Technology LLC Aminophylline 317-34-0 200mg
Aminophylline (CAS 317-34-0) is a small molecule known for its dual action as a competitive nonselective phosphodiesterase inhibitor and as a nonselective antagonist of adenosine receptors In vitro studies indicate an IC50 of 0 12 mM for phosphodiesterase inhibition highlighting its role in modulating intracellular cyclic nucleotide levels Through these mechanisms aminophylline impacts multiple cellular signaling pathways making it a valuable tool in research focused on smooth muscle relaxation inflammatory response and cellular signaling processes related to adenosine and cyclic AMP regulation
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Medchemexpress LLC Clarithromycin | 81103-11-9 | 99.93% | 747.95 | 500 MG
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Clarithromycin has a broad spectrum of antimicrobial activity. It inhibits CYP3A4-catalyzed triazolam alpha-hydroxylation with an IC50 (Ki) value of 56 (43) μM. It significantly inhibits the hERG potassium current and affects autophagic flux by impairing the signaling pathway linking hERG1 and PI3K. It has also shown activity against Mycobacterium avium complex infection in mice.
- Broad spectrum of antimicrobial activity
- Inhibits CYP3A4-catalyzed triazolam alpha-hydroxylation
- Significantly inhibits hERG potassium current
- Affects autophagic flux by impairing the signaling pathway linking hERG1 and PI3K
- Induces intracytoplasmic vacuoles in various cell lines
- Triggers apoptotic cell death in colorectal cancer cells
- Increases LC3-II/LC3-I ratio dose- and time-dependently
- Reduced organ cell counts in animal models of Mycobacterium avium infection
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Sigma Aldrich Fine Chemicals Biosciences Ansamitocin P-3 from Actinosynnema pretiosum >=90% (HPLC) | 66584-72-3 | MFCD00274586 | 1MG
Ansamitocin P-3 from Actinosynnema pretiosum >=90% (HPLC) | Purity: >=90% (HPLC) | Mol Wt: 635.14 | 66584-72-3 | MFCD00274586 | 1MG
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