General Cell Lines and Cell Cultures
Abcam CP 154526 hydrochloride, non-peptide CRF1 receptor antagonist, 50MG
MW 400.99 g/mol, Purity >99%. Potent, selective, non-peptide corticotropin factor receptor-1 antagonist (Ki = 10 nM). Blood-brain barrier permeable. Neuroprotective and antistress agent. Active in vivo and in vitro.
The product is subject to the following: Abcam Restricted Use Statement
Eurofins Discoverx PathHunter U2OS c-Ret-GFRα1 Functional Assay, 2 vials. (93-1054C3)
The PathHunter U2OS c-Ret-GFRα1 Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated c-Ret and GFRα1 dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged c-Ret and an EA-tagged SH2 domain protein. It also overexpresses an untagged coreceptor, GFRα1 Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the cynomolgus version of the protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
ATCC SW48 Quantitative; purified DNA, 3 ug; Human
Purified genomic DNA isolated from the SW-48 human colon adenocarcinoma cell line (ATCC CCL-231). This product was quantified for oncology biomarkers EGFR p.G719S via NGS and ddPCR.
Eurofins Discoverx PathHunter CHO-K1 PTAFR β-Arrestin Cell Line, 2 vials. (93-0236C2)
The PathHunter PTAFR cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. PAF) based activation of PTAFR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged PTAFR and EA-tagged β-Arrestin-2. Activation of PTAFR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Biochain Institute Inc Frozen Tissue Array - Dog Male Adult Normal Tissue, Multi-tissue I, 1 slide/PK
BioChain's dog normal multiple frozen tissue arrays are designed for studying tissue specific cellular localization of genes or proteins of interest in different dog tissues. Up to 30 different frozen tissues from the same male or female dog are mounted on positively charged glass slides. Total RNA and cDNA from those tissues may also be available upon request.
Biochain Institute Inc Frozen Tissue Section - Pulmonary embolism: Lung, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
ATCC Gut Microbiome; Genomic Mix
NGS Standards are mock microbial communities that mimic mixed metagenomic samples. This product comprises an even mixture of genomic DNA prepared from fully sequenced, characterized, and authenticated bacterial species observed in normal and atypical gut microbial communities. Each order for this product is provided with access to run 20 analyses on One Codex, the leading bioinformatics platform for microbial genomics and metagenomics. Specification Range: 2.4x108 genome copies/vial ± 1 log* *Genomic DNA concentrations indicate ATCC manufacturing specifications and are provided as a reference only
Eurofins Discoverx PathHunter CHO-K1 mCNR2 (CB2) β-Arrestin Cell Line, 2 vials. (93-0472C2)
The PathHunter mCNR2 (CB2) cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CP 55,940) based activation of mCNR2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mCNR2 and EA-tagged β-Arrestin-2. Activation of mCNR2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ABclonal Technology ADORA2A Rabbit pAb
This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily, specifically an A2A adenosine receptor. It responds to adenosine, activating G(s) and G(olf) proteins to increase intracellular cAMP levels. The receptor plays key roles in regulating cardiac rhythm, circulation, cerebral and renal blood flow, immune function, pain, and sleep. It is involved in conditions like inflammatory diseases and neurodegenerative disorders. Alternative splicing produces multiple transcript variants, including a read-through transcript with the upstream SPECC1L gene, thought to be non-coding.
ATCC CRFK; Kidney; Cat (Felis catus)
CRFK is a cell exhibiting epithelial morphology that was isolated from the cortex of a female cat. This cell line was deposited by RA Van Deusen.
iQ Biosciences Purified Human CD3 Pan T Cells, 10M cells/vial
High-quality, high-viability (> 90%) human CD3 Pan T cells purified from PBMCs of healthy blood donors sourced from a world-renowned blood center. Highly enriched (> 99%) post-selection purity achieved via magnetic isolation. All orders come with an iQ Certificate of Analysis.
Eurofins Discoverx PathHunter U2OS IκB Degradation Cell Line, 2 vials. (93-0538C3)
The PathHunter U2OS IκB Degradation Cell Line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting the NFκB pathway. This cell line enables detection of IκB levels, allowing for assessment of NFκB pathway activation-induced IκB degradation. This product uses EFC technology. The cell line included overexpresses IκB target protein fused to ProLabel. EA is contained in the detection reagent. Upon pathway-activation-induced degradation of IκB EFC signal is lost. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/pathways.
Eurofins Discoverx Ready-to-Assay Y2 Neuropeptide Receptor Frozen Cells, 2 Vials of Cells. (HTS066RTA)
The Ready-to-Assay Y2 Neuropeptide Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. peptide YY) based activation of NPY2R GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses NPY2R alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of NPY2R, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx ChemiScreen α1D Adrenergic Receptor with N-terminal truncation Membrane Preparation, 1 vial. (HTS216M)
The ChemiScreen α1D Adrenergic Receptor with N-terminal truncation Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of ADRA1D (82-572) surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Accurate Chemical Uni-Sep Maxi Plus, Human Lymphocytes, Filled tubes with 15 ml. medium/tube, 18 tubes/bx
Cell separation media includes cell culture media, cell culture reagents and cell density gradient separation media. These cell separation products are ideal for life science studies and cell research projects worldwide. 18 tubes/bx