Sera
Cayman Chemical DLthreoPPMPhydrochLRIde 50mg
An inhibitor of glucosylceramide synthase; inhibits glucosylceramide synthase by 70, 41, and 62% in MDCK cell homogenates, mouse liver microsomes, and mouse brain homogenates, respectively, at 20 µM; inhibits sphingomyelin synthase activity in P. falciparum-infected erythrocytes and inhibits growth of P. falciparum (IC50 = 0.85 µM)
Abcam Human Vimentin Profiling ELISA Kit, 1 x 96 Tests
Human Vimentin Profiling ELISA Kit is a Quantitative ELISA kit for the measurement of Human Vimentin Profiling in Human in Tissue Lysate, Suspension cells, Tissue Homogenate, Adherent cells samples.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical PyronarIdInphosphate 100mg
An antimalarial agent; active against six P. falciparum drug-sensitive or -resistant strains (IC50s = 1.53-3.94 nM); reduces parasitemia in P. chabaudi-infected mice at 3, 6, and 8 mg/kg in combination with artesunate; inhibits SARS-CoV-2 replication in infected A459-ACE2 cells (IC50 = 198 nM); cytotoxic against a panel of human cancer cells lines (CC50s = 1.6-4.9 µM)
Cayman Chemical PyrImethamIn 50mg
A dihydrofolate reductase inhibitor that prevents the production of tetrahydrofolic acid in P. falciparum and other protozoa; displays a prophylactic effect (ED50 = 0.5 mg/kg) in in vivo antimalarial mouse models
Cayman Chemical PF-03814735 50mg
A reversible inhibitor of both Aurora A and B kinases (IC50s = 0.8 and 5 nM, respectively); also inhibits FLT1, FAK, TrkA, Met, and FGFR1 (IC50s = 10, 22, 30, 100, and 100 nM, respectively)
Cayman Chemical VatlnIbhydrochlorIde 50mg
An antagonist of VEGFR1, VEGFR2, and VEGFR3 with IC50 values of 77, 37, and 190 nM, respectively; less potently inhibits PDGF and c-Kit (IC50 = 600 and 700 nM) and has no effect on additional kinases; completely blocks retinal neovascularization in oxygen-induced ischemic retinopathy in mice
Cayman Chemical MecamylamInhydrochlorIde 50mg
A noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC50 = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC50s range from 1-7 μM)
Cayman Chemical MInocyclInhydrochLRIde hy 50mg
A broad-spectrum tetracycline antibiotic; active against E. faecium in vitro (MIC = 16 mg/L); reduces the number of bacteria in the lung in a mouse model of multi-drug resistant A. baumannii-induced pneumonia at 20 mg/kg every 12 hours; reduces spinal cord lesion size and improves hindlimb function post-injury in a mouse model of acute spinal cord injury at an initial dose of 50 mg/kg and subsequent doses of 25 mg/kg per day for 5 days
Cayman Chemical NourseothrIcInsulfate 50mg
A broad-spectrum antibiotic that inhibits protein synthesis by inducing miscoding; commonly used as a dominant selection antibiotic for genetically modified bacteria, yeasts, fungi, protozoa, plants, and mammalian cells
Cayman Chemical trns-VaccenIc AcId 100mg
An ω-7 fatty acid; dietary administration reduces total body fat, mesenteric fat, and adipocyte size, increases inguinal fat mass, and decreases intestinal and hepatic triglyceride secretion in a rat model of obesity with features of metabolic syndrome at 1% w/w; decreases hepatocellular ballooning and steatosis in the same model; dietary administration of a butter enriched with trans-vaccenic acid decreases serum cholesterol levels and the formation of aortic atherosclerotic lesions in Ldlr-/- mice
Cayman Chemical Isobavachalcon 50mg
A chalcone and flavonoid with diverse biological activities; active against C. albicans and C. neoformans (IC50s = 3 and 7 UG/ml, respectively), as well as T. rubrum and M. audouinii (MIC = 1.2 UG/ml for both); active against various bacteria (MICs = 4.9-39.1 UG/ml); induces mitochondrial-mediated apoptosis in IMR-32 and NB-39 human neuroblastoma cells; inhibits the proliferation of OVCAR-8 ovarian, PC3 prostate, MCF-7 breast, and A549 lung cancer cell lines; reduces dopaminergic neuronal cell death and increases the stay time in the rotarod test in a mouse model of MPTP-induced Parkinson’s disease at 50 mg/kg
Cayman Chemical AsoxImechlorIde 50mg
An asymmetric bis-pyridinium aldoxime that functions as an AChE reactivator through nucleophilic attack of oximate anions on organophosphate-AChE conjugates; demonstrates therapeutic activity in experimental models of organophosphate poisoning
Cayman Chemical 14-PentadecenoIc AcId 100mg
A 15-carbon, long-chain fatty acid that contains an alkene functional group on the terminal carbon of its aliphatic tail
Cayman Chemical 1Stearoyl2MyrIstoylsngly 100mg
An asymmetric phospholipid that can interdigitate with equal length (symmetric) acyl chain phospholipids in bilayer membranes to potentially minimize the hydrophobic mismatch between acyl chains
Cayman Chemical D-LucIferInsodIum salt 100mg
A chemiluminescent substrate of firefly luciferase which produces light upon oxidative decarboxylation in the presence of ATP