Human Sera
Cayman Chemical PemIrolastpotasIum salt 100mg
A histamine H1 receptor antagonist and a mast cell stabilizer that prevents the release of histamine; also blocks the release of substance P, neurokinin A, and calcitonin gene-related peptide from sensory nerves
Cayman Chemical CnaglIflozIn 50mg
An inhibitor of SGLT2 (IC50 = 2.2 nM) that less potently blocks SGLT1 (IC50 = 910 nM); lowers plasma glucose by lowering the renal threshold for glucose and increasing urinary glucose excretion in animals
Cayman Chemical R-DeprenylhydrochlorIde 100mg
A selective, reversible inhibitor of MAO-B (Ki = 0.091 μM) over MAO-A (Ki = 9.06 μM); may ameliorate depression, Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and stroke
Cayman Chemical TIloronhydrochlorIde 50mg
An orally active, antiviral compound that induces interferon production and is reported to have antitumor, anti-inflammatory, and neuroprotective actions
Cayman Chemical TroglItazon 50mg
A selective agonist of PPARγ (EC50s = 0.78 and 0.55 μM for the mouse and human receptors, respectively, in a transactivation assay); selective for PPARγ over PPARα and PPARδ, at which it is inactive at ≤10 μM; exhibits antihyperglycemic and antihyperlipidemic properties in Zucker diabetic fatty rats, reducing plasma glucose and triglyceride levels by 61 and 87% respectively, at 500 mg/kg twice per day; induces cell cycle arrest at the G1 phase in SK-HEP-1 and Hep3B hepatocellular carcinoma cells at 10 μM and increases apoptosis in these cells at ≥30 μM
Cayman Chemical Nmethyl Perfluoroctnsulfo 50mg
A perfluoroalkyl substance; has been found in landfill leachate
Cayman Chemical Daclatsvr 50mg
An NS5A inhibitor (Kds = 8 and 210 nM for the NS5A33-202 and NS5A26-202 residues of HCV genotype 1b, respectively); potently inhibits HCV replication in multiple HCV replicon genotypes (EC50s = 9-146 pM) with the highest potency in genotypes 1b and 4a (EC50s = 9 and 12 pM, respectively); disrupts NS5A subcellular localization when used at a concentration of 1 nM; inhibits HCV RNA synthesis and virion assembly and secretion when used at a concentration of 1 nM; inhibits OAT1B1 and OAT1B3 (IC50s = 1.5 and 3.27 µM, respectively)
Cayman Chemical SureLIghtPerCP CynIn 5 5 100mg
SureLight™ PerCP Cyanine 5.5 is a fluorescent probe used in protein detection Excitation max. λ: 496 nm Emission max. λ: 517 nm Uses: Custom antibody labeling, fluorescence-activated cell sorting, flow cytometry, Luminex, and T cell labeling
Cayman Chemical LevobetaxololhydroCLOrID 100mg
A β1-adrenergic receptor antagonist (Ki = 0.76 nM for the human receptor); selective for β1-ARs over β2-ARs (Ki = 32.6 nM), as well as a panel of 89 additional receptors (IC50s = >1 µM); inhibits isoproterenol-induced cAMP production in human non-pigmented ciliary epithelial cells (Ki = 16.4 nM); topical application reduces intraocular pressure in a cynomolgus monkey model of ocular hypertension at 150 UG/eye
Cayman Chemical NaftIfInhydrochlorIde 100mg
Blocks ergosterol biosynthesis in fungi by inhibiting squalene epoxidase (Ki = 1.1 µM for C. albicans epoxidase)
Cayman Chemical EburnamonIn 50mg
An indole alkaloid with vasodilator and neuroprotective activities; increases cerebral blood flow and capillary circulation in anesthetized dogs at 2.5 mg/kg; prevents scopolamine-induced amnesia in a passive avoidance test in mice at 20 mg/kg; enhances acquisition of the conditioned avoidance response induced by hypobaric hypoxia in rats at 20 mg/kg; increases the onset time to hypoxia-induced brain death in rats at 0.25 mg/kg per minute; increases survival time and inhibits decreases in body temperature induced by hypobaric hypoxia in rats at 45 mg/kg
Cayman Chemical NaloxonazInhydrochlorIde 50mg
A μ-opioid receptor antagonist (Ki = 0.054 nM in a radioligand binding assay); selective for μ-opioid over κ- and δ-opioid receptors (Kis = 11 and 8.6 nM, respectively, in radioligand binding assays); selectively binds to high-affinity µ1-opioid over μ- and δ-opioid receptors (Kds = 0.1, 2, and 5 nM, respectively); reverses sufentanil-induced antinociception, hypercapnia, and hypoxia in rats at 0.16 mg/kg; reduces ethanol self-administration and food intake in rats at 10 mg/kg; inhibits cocaine-induced place preference in rats at 20 mg/kg
Cayman Chemical FloxurIdIn 100mg
An active metabolite of 5-fluorouracil; induces DNA double-strand breaks in thymidylate synthase-deficient FM3A cells, as well as increases dATP levels and decreases dTTP and dGTP levels in wild-type thymidylate synthase-expressing FM3A F28-7 cells at 1 µM; inhibits the proliferation of L1210 and HeLa cells (IC50s = 1.1 and 9.4 nM, respectively); reduces tumor growth by 86.3% in a S180 murine sarcoma model at 200 mg/kg, i.p.