Guinea Pig Whole Blood
Cayman Chemical Linolenic ACD ethyl ester 1g
A bile acid amidate has been found in fecal samples from extremely premature infants with mild or severe brain injuries has been used as a standard for the detection of endogenous bile acid amidates in human plasma and fecal samples
Cayman Chemical DocosahexaenoIc ACD ethyl S
An agonist of LXRa and LXRB induces transactivation of LXRa and LXRB in reporter assays using HEK293T cells (EC50s 0.15 and 0.53 UM respectively) increases protein levels of ABCG1 and ABCA1 in RAW 264.7 and THP-1 cells at 1 or 10 UM induces cholesterol efflux and reduces oxidized LDL-induced lipid accumulation in RAW 264.7 cells at 1 or 10 UM
Cayman Chemical DocosahexaenoIc ACD ethyl S
An imidazoline receptor agonist selectively binds to imidazoline I1 and -I2 receptors over a2-ARs (IC50s 0.034 0.026 and 15 UM respectively) reduces complete Freund’s adjuvant-induced thermal and mechanical hyperalgesia in rats at 10 or 17.8 mg/kg decreases the latency to seizure onset and increases the percentage of animals with grade V seizures to a greater extent in female than male mice reverses cognitive deficits in the 5XFAD transgenic mouse model of Alzheimer’s disease at 5 mg/kg
Cayman Chemical ArachIdonIc ACD 1 2 3 4 513
A pan Akt inhibitor (Ki 160 pmol/L for all three isoforms) that interferes with mitotic progression and bipolar spindle formation slows the progression of Akt-dependent tumors in vivo concomitantly increases Akt Thr308 and Ser473 phosphorylation via a rapid feedback reaction
Cayman Chemical EIcosapentaenoIc ACD Alkyn
An oxidized form of heme that inhibits eIF2aK1 a repressor of eIF-2a used experimentally to induce the expression of heme oxygenase-1 in cells and in animals
Cayman Chemical 8 Z 14 ZEIcosadIenoIc ACD
A paramagnetic nitroxide spin label featuring a methanethiosulfonate group for site-directed spin labeling particularly through disulfide linkages with cysteine residues on proteins
Cayman Chemical DeuTRated ArachIdonIc ACD C
An orally bioavailable SARM that binds to the androgen receptor with a Ki value of 7 nM stimulates muscle weight increase without affecting prostate or seminal vesicle in castrated male rats
Cayman Chemical 4AmInobenzoIc ACD hydrazID
A prodrug form of remogliflozin A inhibits human SGLT2 and SGLT1 (Kis 1.95 and 43.1 M respectively) inhibits increases in plasma glucose levels in a glucose tolerance test in a rat model of STZ-induced diabetes at 3 and 10 mg/ml increases fasting plasma insulin levels and reduces fasting plasma glucose and triglyceride levels as well as urinary glucose excretion in a db/db mouse model of diabetes with hyperinsulinemia and obesity at 10 and 30 mg/kg twice per day for 6 weeks
Cayman Chemical GlycochenodeoxycholIc ACD Ma
Immunogen Phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr53 of mouse NCC Host Rabbit Species Reactivity ( ) Human Mouse Rat Applications IF WB MW 160 kDa
Cayman Chemical DocosahexaenoIc ACD 1 2 3 4
Immunogen Peptide corresponding to amino acid residues from the C-terminus of rat ERK/MAPK Host Rabbit Species Reactivity ( ) Human Mouse Rat Applications ICC and WB MW 44 and 42 kDa for ERK1/MAPK3 and ERK2/MAPK1 respectively
Cayman Chemical PalmItoleIc ACD methyl STR
A prodrug form of imidaprilat inhibits swine renal cortex ACE activity in vitro (IC50 9 9 UM) inhibits the angiotensin I-induced pressor response in normotensive rats decreases blood pressure in spontaneously hypertensive and 2K-1C renal hypertensive rats at 2 mg/kg decreases stroke incidence and increases survival in stroke-prone spontaneously hypertensive rats fed a high-salt diet reduces urinary albumin excretion in a mouse model of streptozotocin-induced diabetes at 5 mg/kg
Cayman Chemical DocosapentaenoIc ACD ethyl50mg
An active metabolite of losartan inhibits arachidonic acid-induced platelet aggregation in isolated human platelet-rich plasma at 10 pM a PPARY agonist (EC50 17 1 UM in COS-7 cells expressing human PPARY using a reporter assay) increases lipid accumulation in 3T3-L1 adipocytes at 10 UM decreases superoxide production by NOX in isolated human PBMCs in a concentration-dependent manner inhibits LPS-induced increases in COX2 mRNA expression and LPS- or angiotensin II-induced increases in supernatant PGF2a levels in HUVECs at 10 UM
Cayman Chemical DocosapentaenoIc ACD ethyl10mg
An active metabolite of losartan inhibits arachidonic acid-induced platelet aggregation in isolated human platelet-rich plasma at 10 pM a PPARY agonist (EC50 17 1 UM in COS-7 cells expressing human PPARY using a reporter assay) increases lipid accumulation in 3T3-L1 adipocytes at 10 UM decreases superoxide production by NOX in isolated human PBMCs in a concentration-dependent manner inhibits LPS-induced increases in COX2 mRNA expression and LPS- or angiotensin II-induced increases in supernatant PGF2a levels in HUVECs at 10 UM
Cayman Chemical DocosatrIenoIc ACD methyl25mg
A second messenger that is biosynthesized from GTP by guanylate cyclases activates protein kinase G (PKG) and modulates ion channel conductance with signaling affecting diverse processes including smooth muscle relaxation and proliferation phototransduction and energy homeostasis
Cayman Chemical 5MethoxyIndole3ACtIc ACD 500mg
A phospholipid has been used in the formation of PERLs that reduce cellular cholesterol levels in human PMBCs and decrease the secretion of HIV-1 particles in PBMCs infected with HIV-1LAI has been used as a component of lipid monolayers and small unilamellar vesicles to study the effect of phospholipid composition on membrane fluidity
