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Protein phosphorylation antibody pairs are sets of antibodies that are known to be capable of detecting specific protein phosphorylation; they can be used together to detect specific phosphorilated sites via an immunoassay.
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The protein encoded by this gene is a serine/threonine kinase that regulates cell polarity and energy metabolism and functions as a tumor suppressor. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic, and testicular cancers.
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Histones play a critical role in transcriptional regulation cell cycle progression and developmental events Histone acetylation deacetylation alters chromosome structure and affects transcription factor access to DNA The protein encoded by this gene belongs to class II of the histone deacetylase acuc apha family It possesses histone deacetylase activity and represses transcription when tethered to a promoter This protein does not bind DNA directly but through transcription factors MEF2C and MEF2D It seems to interact in a multiprotein complex with RbAp48 and HDAC3 [provided by RefSeq Jul 2008]
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The product of this gene belongs to the serine threonine protein kinases family and to the Ca(2 ) calmodulin-dependent protein kinases subfamily Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses This calcium calmodulin-dependent protein kinase is composed of four different chains alpha beta gamma and delta The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning In addition to its calcium-calmodulin (CaM)-dependent activity this protein can undergo autophosphorylation resulting in CaM-independent activity Several transcript variants encoding distinct isoforms have been identified for this gene
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