An inhibitor of MMPs; selective for MMP-2, MMP-9, and MMP-13 (Kis= 0.22, 0.55, 0.52 nM, respectively) over MMP-3 and MMP-1 (Kis= 9.3 and 590 nM, respectively); reduces hepatocyte apoptosis and bile infarcts and increases survival in a mouse model of bile duct ligation-induced cholestatic liver injury at 10 mg/kg