Goat Secondary Antibodies
Cayman Chemical Prulifloxacin, Purity: ≥98%, CAS: 123447-62-1, 1 g
A prodrug from of ulifloxacin; increases survival in various mouse models of systemic bacterial infection (ED50s = 0.35-23 mg/kg); increases survival in a mouse model of K. pneumoniae-induced respiratory tract infection (ED50 = 0.981 mg/kg)
Cayman Chemical Buflomedil (hydrochloride), Purity: ≥95%, CAS: 35543-24-9, 5 g
An α-AR antagonist and vasoactive compound; binds to rat α1A- and α1B-ARs (Kis = 4.06 and 6.84 µM, respectively) and human platelet α2-ARs (IC50 = 1 µM); inhibits phenylephrine-, clonidine-, sypathetic nerve stimulation-, or norepinephrine-induced contration of isolated canine saphenous veins from 0.06-60 µM; inhibits ADP-, collagen-, or epinephrine-induced aggregation of isolated human platelets at 100 µM; reduces hippocampal neuronal cell death in a rat model of carotid clamping-induced ischemia-reperfusion injury at 10 mg/kg
Cayman Chemical 1,3-Diphenylurea, Purity: ≥98%, CAS: 102-07-8, 250 g
A cytokinin; increases fresh weight of tobacco plant tissue from 1-16 mg/L in growth media; increases the growth of cultured P. lunatus callus tissue at 32 and 100 µM; exogenous application during first-passage culture induces second-passage cytokinin autonomy in cultured P. lunatus tissue at 32 and 100 µM
Cayman Chemical 2-Fluoroadenine, Purity: ≥98%, CAS: 700-49-2, 500 mg
A heterocyclic building block; has been used in the synthesis of Hsp90 inhibitors that have anticancer activity in vitro; cytotoxic to CEM human leukemia cells (IC50 = 0.15 µM)
Cayman Chemical Chelidonic Acid, Purity: ≥95%, CAS: 99-32-1, 5 g
A pyran with diverse biological activities; inhibits rat brain glutamate decarboxylase (Ki = 1.2 μM); reduces serum IL-6 and TNF-α levels, colonic COX-2 and PGE2 levels, and the disease activity index score in a mouse model of DSS-induced ulcerative colitis at 20 mg/kg per day; inhibits ovalbumin challenge-induced decreases in spleen IFN-γ levels and increases in serum, spleen, and nasal mucosa IgE levels, spleen IL-4 levels, and nasal mucosa eosinophil and mast cell infiltration in a mouse model of ovalbumin-sensitized allergic rhinitis at 2 mg/kg
Cayman Chemical 1,1'-(Azodicarbonyl)dipiperidine, Purity: ≥98%, CAS: 10465-81-3, 5 g
A Mitsunobu reagent; has been used as a reagent in the synthesis of GPR120 agonists with antidiabetic activity and PPARα, PPARγ, and PPARδ triple agonists
Cayman Chemical 6,7-Dihydro-5H-quinolin-8-one, Purity: ≥98%, CAS: 56826-69-8, 500 mg
A synthetic intermediate
Cayman Chemical L-Alanine methyl ester (hydrochloride), Purity: ≥95%, CAS: 2491-20-5, 50 g
An amino acid-containing building block; has been used in the synthesis of AZT nucleotides with anti-HIV activity, as well as anticancer agents
Cayman Chemical THUNDRPhosphoRPS6S240S 4800Wel
Sandwich TR-FRET immunoassay for semi-quantitative detection of Phospho-Ribosomal Protein S6 (S240/S244) in cell lysates.
Sino Biological Anti-TREM-1 Antibody, Rabbit Polyclonal
Produced in rabbits immunized with purified, recombinant Human TREM-1 (rh TREM-1; Catalog#10511-H08H; NP_061113.1; Met1-Arg200). TREM-1 specific IgG was purified by Human TREM-1 affinity chromatography.
Cayman Chemical PPARLBD LIgnd Screeng384
A growth hormone secretagogue and ghrelin receptor agonist binds to GHS-R1a (IC50 123 nM for the human receptor) oral administration increases plasma growth hormone levels in dogs at 1 mg/kg decreases gastric acid secretion in pylorus-ligated rats at 0.01 or 1 nmol/animal i.c.v. increases acute food intake and body weight in mice at 10 mg/kg decreases the number and total duration of seizures in mice induced with dopamine D1 receptor kindling using SKF 81297
Cayman Chemical Cyclocytidine (hydrochloride), Purity: ≥95%, CAS: 10212-25-6, 1 g
A prodrug form of cytarabine; hydrolyzed to cytarabine in vivo; inhibits the growth of L5178Y leukemia cells in vitro (IC50 = 0.041 µg/ml); inhibits DNA synthesis by inhibiting thymidine incorporation into DNA (IC50 = 110 µg/ml); increases lifespan in an L1210 mouse leukemia model at 3-1,000 mg/kg per day; transiently increases blood pressure in dogs, cats, and rats at 5-100 mg/kg
Cayman Chemical 4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside, Purity: ≥98%, CAS: 37067-30-4, 250 mg
A fluorogenic substrate for β-hexosaminidases; is cleaved by β-hexosaminidases to release the fluorescent moiety 4-ΜU; ex = 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively; em = 445 to 455 nm, increasing as pH decreases; has been used to quantify β-hexosaminidase activity in serum or leukocytes from patients with GM2 gangliosidoses such as Tay-Sachs disease
Cayman Chemical ntIDNP PolycLNal ANTIBDY 500uL
An antispasmodic agent an inhibitor of AChE (Kis 36 and 45 M for bovine erythrocyte and electric eel enzyme respectively) inhibits acetylcholine-induced contractions of isolated guinea pig ileum at 2.5 M
Cayman Chemical (R)-Cetirizine (hydrochloride), Purity: ≥98%, CAS: 130018-87-0, 250 mg
A selective histamine H1 receptor antagonist; the (R)-enantiomer of cetirizine; binds to the H1 receptor with higher affinity than cetirizine (Kis = 3 and 6 nM, respectively) and is highly selective for H1 over M1-M5 receptors; decreases production of RANTES and eotaxin following antigen stimulation in mouse eosinophils in vitro (MEC = 0.05 µM); dose-dependently decreases histamine-induced nasal rubbing and sneezing in mice (0.01-1% solution)