Goat Secondary Antibodies
Cayman Chemical 2Deoxy3O Nmethylnthr 3.1mg
A fluorescent derivative of ATP; inhibitor of B. anthracis edema factor AC toxin (Ki = 40 nM); decreases inositol phosphate formation in CHO-K1 cells expressing the human purinergic P2Y12 receptor at 100 µM
ABclonal Technology MICA Rabbit pAb
This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.
Cayman Chemical Tosyl Phenylalnyl CLOrometh
An irreversible inhibitor of chymotrypsin-like proteases that has been shown to affect cell proliferation, apoptosis, and tumorigenesis; disrupts PDK1 signaling to the AGC kinases and also inhibits superoxide production
Cayman Chemical Cefamndole Nafate 1g
A prodrug from of cefamandole; inhibits the growth of E. cloacae, E. coli, K. pneumoniae, P. mirabilis, P. vulgaris, P. morganii, S. aureus, and S. pyogenes in vitro (MICs = 0.1-50 μg/ml); protects against E. cloacae, E. coli, K. pneumoniae, P. mirabilis, P. vulgaris, P. morganii, S. aureus, and S. pyogenes infection in mice (ED50s = 0.3-334 mg/kg); protects against tobramycin-induced nephrotoxicity at 500 mg/kg
ABclonal Technology RAC2 Rabbit pAb
This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6.
Cayman Chemical HyodeoxycholIc AcId 25g
A secondary bile acid; decreases plasma VLDL and LDL cholesterol levels and reduces fasting glucose levels and atherosclerotic lesion size in LDL receptor knockout mice fed a Western diet at 1.25% in the diet; serum levels are increased in patients with Crohn’s disease or ulcerative colitis
Cayman Chemical 3 4-Methylenedioxyphenmetrazi
An analytical reference standard that is categorized as a phenmetrazine; intended for research and forensic applications
Cayman Chemical trans-10-hydroxy Nortriptylin
An active metabolite of amitriptyline and nortriptyline; formed from amitriptyline and nortriptyline by CYP2D6; inhibits norepinephrine reuptake in rat cortical slices and isolated human plasma (EC50s = 160 and 176 nM, respectively)
Cayman Chemical IrsogladInmaleate 250mg
A gastroprotective agent; increases transfer of Lucifer yellow CH between isolated rabbit gastric epithelial cells, indicating enhanced GJIC; inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats at 3 mg/kg, effects that can be prevented by L-NAME; inhibits fMLP-induced superoxide anion production and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to rolipram
Cayman Chemical ThIabendazole 50g
A broad-spectrum anthelmintic active against a variety of helminths; kills greater than 95% of adult worms from ten genera; inhibits egg production and disrupts larval development; inhibits fumarate reductase in helminths, blocking energy production through the citric acid cycle; inhibits methionine aminopeptidase in E. coli (Ki = 40 nM; IC50 = 47.2 nM)
Cayman Chemical 3 3-DIhexyloxacarbocynIn 500mg
A fluorescent dye; ex/em spectra = 484/501 nm, respectively; accumulates in ER at high concentrations and has been used to visualize ER in moss, yeast, and muscle cells; accumulates in mitochondria at low concntrations and has been used to assess mitochondrial dislocations, fusion, and fission in living cells, as well as to visualize cellular apoptosis; used to assess cell membrane potential, as depolarization directly correlates with increased fluorescence; photoexcitation inactivates intracellular organelle movement and inhibits microtubule polymerization in vitro
Cayman Chemical Precelys MInIlys IHM Boar 1ea
An accessory for the Precellys Minilys Personal Tissue Homogenizer (Item No. 10435)