Goat Secondary Antibodies
Cayman Chemical 2′,3′-Dideoxyadenosine, Purity: ≥98%, CAS: 4097-22-7, 50 mg
A prodrug form of ddATP; inhibits HIV replication in HIV-infected MT-4 cells at 5 and 125 µM; protects ATH8 cells against the cytopathic effect of HIV (EC50 = 2.7 µM)
Cayman Chemical 1-Methylpseudouridine, Purity: ≥98%, CAS: 13860-38-3, 50 mg
A nucleoside analog; increases the thermodynamic and biological stability of RNA; 1-methylpseudouridine-containing mRNA does not induce IFN-β secretion in A549 cells, indicating low immunogenicity; intramuscular or intradermal administration of luciferase mRNA containing 1-methylpseudouridine via lipid complexes increases luciferase activity in mice; has been incorporated as a modification in mRNA that has been used in the development of mRNA-based vaccines
Cayman Chemical st-Ht31 (ammonium salt), Purity: ≥98%, 10 mg
A cell-permeable stearated peptide; decreases PKA membrane anchoring but not activity in a reporter assay using BHK-21 fibroblasts at 50 µM; reduces capacitance, hyperactivation, as well as prevents in vitro fertilization, in mouse sperm at 1 and 3 µM; increases cholesterol export from ABCA1-expressing BHK-21 cells and RAW 264.7 macrophages at 50 µM
Cayman Chemical Prochlorperazine (maleate), Purity: ≥98%, CAS: 84-02-6, 250 mg
A dopamine D2 receptor antagonist; binds to rat recombinant D2 receptors (Ki = 4.7 nM); binds to D2 in rat striatal membranes (Ki = 2.9 nM); binds to rat recombinant D3 receptors (Ki = 35 nM); binds to the 5-HT3 receptor in N1E-115 mouse neuroblastoma cell membranes (Ki = 1.2 μM); increases the latency to paw licking in a hot plate test at 2 mg/kg, indicating analgesia; inhibits apomorphine-induced emesis in dogs (ED50 = 0.34 mg/kg)
Cayman Chemical Erlotinib (hydrochloride), Purity: ≥98%, CAS: 183319-69-9, 500 mg
An EGFR inhibitor (Ki = 2.7 nM); selective for EGFR over Src and Abl at 0.1 µM; induces caspase-3 and -7 activity in NCI H358 cells at 1 µM; reduces EGFR autophosphorylation in an HN-5 mouse xenograft model at 25 mg/kg
Cayman Chemical Sorafenib (tosylate), Purity: ≥98%, CAS: 475207-59-1, 5 g
A multi-kinase inhibitor; inhibits Raf-1 and B-RAF (IC50s = 6 and 22 µM, respectively); inhibits VEGFR2, VEGFR3, PDGFRβ, FLT3, and c-Kit (IC50s = 90, 15, 20, 57, and 58 nM, respectively); selective for these kinases over 12 other kinases (IC50s = >10 µM for all); inhibits proliferation of PLC/PRF/5 and HepG2 cells (IC50s = 6.3 and 4.5 µM, respectively); inhibits tumor growth in a PLC/PRF/5 mouse xenograft model at 30 mg/kg; induces ferroptotic cell death in HT-1080 fibrosarcoma cells at 10 µM but not in a variety of other cancer cell lines; inhibits HCV replication in Huh7.5 cells (IC50 = 7.2 µM)
Cayman Chemical Decanoic Acid (sodium salt), Purity: ≥95%, CAS: 1002-62-6, 50 g
A medium-chain saturated fatty acid; a non-competitive antagonist at AMPA receptors; selectively reduces glutamate-induced currents in Xenopus oocytes expressing GluA2/3 subunit-containing AMPA receptors (IC50 = 0.52 mM) over those expressing GluA1 (IC50 = 2.09 mM) or GluA1/2 subunits (IC50 = 1.16 mM); inhibits epileptiform activity induced by pentylenetetrazole or low magnesium in rat hippocampal slices; induces contractions in isolated guinea pig duodenum at 1 mM; increases the escape threshold in an orofacial mechanical stimulation test in rats when administered as a 30% topical ointment; plasma levels of decanoic acid are increased in patients with colorectal cancer when compared to patients with breast cancer or ulcerative colitis or without cancer
CPC Scientific H-Pro-Phe-Thr-Arg-Asn-Tyr-Tyr-Val-Arg-Ala-Val-Leu-His-Leu-OH (trifluoroacetate salt) 5MG
ONE-LETTER SEQUENCE: PFTRNYYVRAVLHLMOLECULAR FORMULA: C83H125N23O19MOLECULAR WEIGHT:1749.1STORAGE CONDITIONS: -20 5CRESEARCH AREA: CancerREFERENCES: M.-Y.Park et al., Biochem. Biophys. Res. Commun. , 204, 924 (1994)
Cayman Chemical Methyl Gallate, Purity: ≥98%, CAS: 99-24-1, 100 g
A phenol with diverse biological activities; reduces adipogenic hormonal stimulation-induced lipid accumulation in 3T3-L1 cells at 50 µM; active against V. cholerae in vitro (MIC = 32 µg/ml) and reduces V. cholerae-induced intestinal fluid accumulation in suckling mice at 50, 100, and 200 mg/kg; reduces tumor growth and decreases the number of intratumor CD25+Foxp3high Tregs in an EL-4 model of murine lymphoma; reduces knee joint edema and leukocyte, neutrophil, and mononuclear cell infiltration in a mouse model of zymosan-induced arthritis at 0.7, 7, and 70 mg/kg
Cayman Chemical 7-(Diethylamino)coumarin-3-carboxylic Acid, Purity: ≥95%, CAS: 50995-74-9, 100 mg
A fluorescent probe; has been used as a FRET acceptor conjugated to neomycin B or tobramycin for use in the analysis of bacterial RNA binding; has been used as a reactive probe for the derivatization of sulfonamides for LIF detection; ex/em = 407/472 nm, respectively
Cayman Chemical 2'-O-Methyl-5-methyluridine, Purity: ≥98%, CAS: 55486-09-4, 250 mg
A modified nucleoside; has been found in tRNA isolated from rabbit liver
Cayman Chemical Obidoxime (chloride), Purity: ≥95%, CAS: 114-90-9, 1 g
An AChE modulator; induces inhibition and activation of bovine erythrocyte AChE in the presence and absence of ACh, respectively, at 3 mM; induces reactivation of tabun-inhibited AChE in rat blood and diaphragm and reduces tabun-induced lethality in mice at 10.5 mg/kg; intranasal administration reduces seizure duration and severity and prevents mortality in a rat model of paraoxon-induced organophosphate poisoning
Cayman Chemical trans-10-hydroxy Nortriptylin
An active metabolite of amitriptyline and nortriptyline; formed from amitriptyline and nortriptyline by CYP2D6; inhibits norepinephrine reuptake in rat cortical slices and isolated human plasma (EC50s = 160 and 176 nM, respectively)
Immunoreagents Inc GOAT A-RAT IGG AP
Secondary Antibody; Goat anti-rat IgG (H&L) - Affinity Pure, min x w/Bo, Gt, Hu Rb or Mu IgG (highly absorbed against mouse IgG), Host: Goat, Format: Liq, Label: None, Applications: WB, ELISA, IHC/ICC, IF, IP, FC
Cayman Chemical Phenazopyridine (hydrochloride), Purity: ≥98%, CAS: 136-40-3, 10 g
An azo dye with analgesic properties; decreases the bladder distension-induced firing rate of afferent bladder Aγ-fibers, but not C-fibers, in anesthetized rats at 0.3, 1, and 3 mg/kg