Rabbit Secondary Antibodies
ABclonal Technology 488 Rabbit anti-Human CD97
This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors which mediate cell-cell interactions These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit which associate at the cell surface as a receptor complex The encoded protein may play a role in cell adhesion as well as leukocyte recruitment activation and migration and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55 Expression of this gene may play a role in the progression of several types of cancer Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19
ABclonal Technology 647 Rabbit anti-Human CD153
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family This cytokine is a ligand for TNFRSF8 CD30 which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch This cytokine was shown to enhance cell proliferation of some lymphoma cell lines while to induce cell death and reduce cell proliferation of other lymphoma cell lines The pleiotropic biologic activities of this cytokine on different CD30 lymphoma cell lines may play a pathophysiologic role in Hodgkin s and some non-Hodgkin s lymphomas Two transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 647 Rabbit anti-Human GSK3B
The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily It is a negative regulator of glucose homeostasis and is involved in energy metabolism inflammation ER-stress mitochondrial dysfunction and apoptotic pathways Defects in this gene have been associated with Parkinson disease and Alzheimer disease
ABclonal Technology 647 Rabbit anti-Human TNF-a
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily This cytokine is mainly secreted by macrophages It can bind to and thus functions through its receptors TNFRSF1A TNFR1 and TNFRSF1B TNFBR This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation differentiation apoptosis lipid metabolism and coagulation This cytokine has been implicated in a variety of diseases including autoimmune diseases insulin resistance psoriasis rheumatoid arthritis ankylosing spondylitis tuberculosis autosomal dominant polycystic kidney disease and cancer Mutations in this gene affect susceptibility to cerebral malaria septic shock and Alzheimer disease Knockout studies in mice also suggested the neuroprotective function of this cytokine
ABclonal Technology 488 Rabbit anti-Human CD27
The protein encoded by this gene is a member of the TNF-receptor superfamily This receptor is required for generation and long-term maintenance of T cell immunity It binds to ligand CD70 and plays a key role in regulating B-cell activation and immunoglobulin synthesis This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8 JNK Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor CD27-binding protein (SIVA) a proapoptotic protein can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor
ABclonal Technology 488 Rabbit anti-Human CEACAM6
This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma This gene affects the sensitivity of tumor cells to adenovirus infection The protein encoded by this gene acts as a receptor for adherent-invasive E coli adhesion to the surface of ileal epithelial cells in patients with Crohn s disease This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19
ABclonal Technology 488 Rabbit anti-Human Siglec-8
Sialic acid-binding immunoglobulin (Ig)-like lectins or SIGLECs (e g CD33 (MIM 159590)) are a family of type 1 transmembrane proteins each having a unique expression pattern mostly in hemopoietic cells SIGLEC8 is a member of the CD33-like subgroup of SIGLECs which are localized to 19q13 3-q13 4 and have 2 conserved cytoplasmic tyrosine-based motifs an immunoreceptor tyrosine-based inhibitory motif or ITIM (see MIM 604964) and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM MIM 603492) that mediates an association with SLAM-associated protein (SAP MIM 300490) (summarized by Foussias et al 2000 [PubMed 11095983]) [supplied by OMIM May 2010]
ABclonal Technology 450 Rabbit anti-Human CD94
Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation Several genes of the C-type lectin superfamily including members of the NKG2 family are expressed by NK cells and may be involved in the regulation of NK cell function KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus Several transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 488 Rabbit anti-Human ULBP2
This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety or secreted Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6
Human IGHG1 PAb 20ul (Sino Biological)
Produced in rabbits immunized with recombinant human IgG1-Fc (Catalog#10702-HNAH; P01857-1; Glu99-Lys330,C103S). This polyclonal antibody was purified by antigen affinity chromatography.
ABclonal Technology 594 Rabbit anti-Human CD38
The protein encoded by this gene is a non-lineage-restricted type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5 -diphosphate-ribose an intracellular calcium ion mobilizing messenger The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein This protein has an N-terminal cytoplasmic tail a single membrane-spanning domain and a C-terminal extracellular region with four N-glycosylation sites Crystal structure analysis demonstrates that the functional molecule is a dimer with the central portion containing the catalytic site It is used as a prognostic marker for patients with chronic lymphocytic leukemia Alternative splicing results in multiple transcript variants
ABclonal Technology 594 Rabbit anti-Human CD146
Melanoma cell adhesion molecule (MCAM MUC18 CD146) is an immunoglobulin superfamily member identified as a cell surface adhesion protein and a marker for melanoma progression and metastasis MCAM is expressed in vascular endothelial cells activated T lymphocytes smooth muscle and bone marrow stromal cells Its expression increases in endothelial cells from angiogenesis-related disorders such as inflammatory bowel disease Crohn s disease rheumatoid arthritis tumors and chronic renal failure MCAM-expressing human mesenchymal stromal cells (hMSC) help maintain the self-renewal of hematopoietic stem and progenitor cells (HSPC) through direct contact possibly involving Notch signaling Research suggests MCAM also plays a role in multiple sclerosis where endothelial MCAM in the blood-brain barrier facilitates lymphocyte transmigration contributing to inflammatory lesions in the central nervous system
ABclonal Technology 647 Rabbit anti-Human TIGIT
This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH) The protein has been shown to bind PVR with high affinity this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses
![Abcam Rabbit monoclonal [H169-1-5] Anti-Human IgG Fc](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC1789538.JPG-250.jpg)
Abcam Rabbit monoclonal [H169-1-5] Anti-Human IgG Fc
Rabbit monoclonal [H169-1-5] Anti-Human IgG Fc
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology 488 Rabbit anti-Human CaSR
The protein encoded by this gene is a plasma membrane G protein-coupled receptor that senses small changes in circulating calcium concentration The encoded protein couples this information to intracellular signaling pathways that modify parathyroid hormone secretion or renal cation handling and thus this protein plays an essential role in maintaining mineral ion homeostasis Mutations in this gene are a cause of familial hypocalciuric hypercalcemia neonatal severe hyperparathyroidism and autosomal dominant hypocalcemia