Signal Transduction Reagents and Kits
Medchemexpress LLC Allocryptopine | 485-91-6 | 369.41 | 5 MG
Allocryptopine, a derivative of tetrahydropalmatine, is extracted from *Macleaya cordata* (Thunb.) Pers. Papaveraceae. It has antiarrhythmic effects and potently blocks human ether-a-go-go related gene (hERG) current. This product is for research use only.
- Has antiarrhythmic effects.
- Potently blocks human ether-a-go-go related gene (hERG) current.
- Purity: 99.53%.
- Structure classification: alkaloids, isoquinoline alkaloids.
Medchemexpress LLC UK122 TFA | 940290-58-4 | 99.85% | 405.33 | 100 MG
UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM. It exhibits minimal inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC50 >100 μM). This 4-oxazolidinone analogue acts as an anticancer agent by inhibiting cancer cell migration and invasion.
- Dose-dependently inhibits cell migration
- Significantly reduces invasiveness of CFPAC-1 cells
- Does not affect cell growth or cell morphology in CFPAC-1 cells at certain concentrations
- Appears as a white to yellow solid
- Recommended for research use only
![CPC Scientific 4-(4-Dimethylaminophenylazo)benzoyl-Tyr-Val-Ala-Asp-Ala-Pro-Val-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acid 0.5MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00111436-SUBS-016.PNG-250.jpg)
CPC Scientific 4-(4-Dimethylaminophenylazo)benzoyl-Tyr-Val-Ala-Asp-Ala-Pro-Val-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acid 0.5MG
SEQUENCE: 4-(4-Dimethylaminophenylazo)benzoyl-Tyr-Val-Ala-Asp-Ala-Pro-Val-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acidONE-LETTER SEQUENCE: 4-(4-Dimethylaminophenylazo)benzoyl-YVADAPV-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acidMOLECULAR FORMULA: C61H76N12O14S1MOLECULAR WEIGHT: 1233.39STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [161877-70-9]SYNONYMS: Caspase 1 (ICE) Substrate; dabcyl-yvadapv-edans; dabcyl-tyr-val-ala-asp-ala-pro-val-edans; ICE Substrate Ii; il-1-beta Converting Enzyme Substrate Ii; il-1b Converting Enzyme Substrate Ii; 4-(4-dimethylaminophenylazo)benzoyl-tyr-val-ala-asp-ala-pro-val-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acid; 4-(4'-dimethylaminophenylazo)benzoyl-tyrosyl-valyl-alanyl-aspartyl-alanyl-prolyl-valyl-5((2-aminoethyl)amino)naphthalene-1-sulfonic acidRESEARCH AREA: ApoptosisREFERENCES:M.W. Pennington et al., Peptide Res., 7, 72 (1994)M. Los et al., Nature 375, 81 (1995)SKU(s): SUBS-016A, SUBS-016B
Medchemexpress LLC Tulobuterol | 41570-61-0 | MFCD00867022 | 99.7% | 100 MG
Tulobuterol is a long-acting β2-adrenoceptor agonist that helps reduce the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. This sympathomimetic agent is also used as a transdermal patch, increasing normal diaphragm muscle strength. It is intended for research use only.
- Acts as a β2-adrenoceptor agonist
- Reduces RV14 RNA levels and sICAM-1 concentrations in infected cells
- Decreases acidic endosome numbers and fluorescence
- Inhibits RV14 infection-induced secretion of inflammatory cytokines (IL-1β, IL-6, and IL-8)
- Restores and maintains diaphragm muscle contractility
Montana Molecular Green Downward GENIe cGMP Sensor Kit D0800G, 30mL, CMV
Measure cyclic GMP (cGMP) signaling dynamics and ascertain the specificity of PDE inhibitors or SNP activators with this live cell fluorescent assay. Add GENIe to your cells and measure robust signals the next day on an automated plate reader or fluorescence imaging system. Decreasing green fluorescence indicates cGMP increase. The assay is genetically encoded and packaged in BacMam for efficient transduction in most cell types - including uniform and near 100% efficiency in HEK293 cells as well as expression in many primary or iPSC-derived cells. Kit includes soluble guanylate cyclase..
Enzo Life Sciences (2R,4R)-APDC (1mg). CAS: 169209-63-6
Selective agonist for group II mGluRs. Inhibits the NADPH-oxidase dependent ROS system. Alternative name: LY-314,593, (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid. Purity: ≥98% (HPLC). Solubility: Soluble in water. Long Term Storage: Ambient.
Echelon Biosciences Research Labs 1-Hydroxy-2-methyl-2-buten-4-yl 4-diphosphate (HDMAPP) 1 mg
1-Hydroxy-2-methyl-2-buten-4-yl 4-diphosphate (HDMAPP or HMBPP) is an intermediate in the non-mevalonate pathway and is biosynthesized from 2-C-Methyl-D-erythritol 2,4-cyclophosphate (cMEPP) by IspG (GcpE). It is the substrate for IspH (LytB) yielding IPP and DMAPP. In addition, HDMAPP is the most potent VgVd T-cell activator identified. This item is non returnable
CPC Scientific Ac-Tyr-Val-Lys-Asp-CHO 1MG
Affinity ligand for interleukin-1b converting enzyme. Slow binding caspase-1 (ICE) inhibitor with low selectivity.SEQUENCE: Ac-Tyr-Val-Lys-Asp-CHOONE-LETTER SEQUENCE: Ac-YVKD-CHOMOLECULAR FORMULA: C26H39N5O8MOLECULAR WEIGHT: 549.6STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [147821-01-1]SYNONYMS: RESEARCH AREA: ApoptosisREFERENCES:T.L. Graybill et al., Int. J. Peptide Protein Res., 44, 173 (1994)N.A. Thornbery et al., Nature, 356, 768 (1992)SKU(s): CASP-015A
Apexbio Technology LLC Zolmitriptan 139264-17-8 100mg
Zolmitriptan (CAS 139264-17-8) is a synthetic small molecule that functions as a selective agonist of serotonin 5-HT1B and 5-HT1D receptors By stimulating these receptors zolmitriptan modulates trigeminovascular neurotransmission leading to cranial vasoconstriction and inhibition of pro-inflammatory neuropeptide release These mechanisms underlie its ability to acutely alleviate migraine attacks both with and without aura as well as cluster headaches In biomedical research zolmitriptan serves as a tool compound for investigating serotonergic signaling pathways involved in nociception and vascular regulation associated with headache disorders
Echelon Biosciences Research Labs PI(4,5)P2 PolyPIPosomes 0.25 mL
PolyPIPosomes are polymerized liposomes that show markedly increased stability (up to 6 months) vs. conventional liposomes. A biotin tag is incorporated for easy detection of PIPn-binding proteins with streptavidin reagents. PolyPIPosomes are provided as a 1mM total lipid solution containing 5% PIP. Each order of 250 L or 1 mL of PolyPIPosomes includes 100 L of Control PolyPIPosomes. This item is non returnable
Echelon Biosciences Research Labs PI(5)P PolyPIPosomes 0.1 mL
PolyPIPosomes are polymerized liposomes that show markedly increased stability (up to 6 months) vs. conventional liposomes. A biotin tag is incorporated for easy detection of PIPn-binding proteins with streptavidin reagents. PolyPIPosomes are provided as a 1mM total lipid solution containing 5% PIP. Each order of 250 L or 1 mL of PolyPIPosomes includes 100 L of Control PolyPIPosomes. This item is non returnable
Enzo Life Sciences AMPIPROBE Ureaplasma spp. / M. genitalium / M. hominis Assay Kit (100tests)
The AMPIPROBE Ureaplasma spp. / M. genitalium / M. hominis (UMM) Assay is a real-time polymerase chain reaction (qPCR) assay for the qualitative detection of Ureaplasma spp. (Ureaplasma parvum and Ureaplasma urealyticum), Mycoplasma genitalium, and Mycoplasma hominis DNA. The kit uses the AMPIPROBE assay platform which takes advantage of paired fluorophore- and quencher-labeled primers specific for each of the target species as well as an internal control. The kit contains all reagents necessary for PCR-based detection of Ureaplasma spp., Mycoplasma genitalium, and Mycoplasma hominis DNA. A positive PCR control consisting of a mixture of the target templates and a negative PCR control that results negative for UMM, but positive for the internal control (human β-globin). Please read the complete kit insert before performing this assay. Applications: qPCR. Species reactivity: Mycoplasma hominis, Mycoplasma genitalium, Ureaplasma spp.