Signal Transduction Reagents and Kits
Echelon Biosciences Research Labs PI(4)P DIC8 AMMONIUM 100 ug
Phosphatidylinositol 4-phosphate diC8 (PI(4)P diC8) is a synthetic, purified dioctanoyl PI(4)P.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4-phosphate (PI(4)P) is the biosynthetic precursor to PI(4,5)P2 and has an important roles in regulating sphingomyelin and glycosphingolipid metabolism and membrane trafficking at the exit of the Golgi complex. This item is non returnable
Enzo Life Sciences Z-prolyl-prolinal (25mg). CAS: 86925-97-5
A potent and selective inhibitor of prolyl endopeptidase (PEP/PREP/POP, EC 3.4.21.26). Ki=0.35 nM for mouse brain enzyme. Inhibits the cleavage of arginine-vasopressin, gonadotropin-releasing hormone, and other peptides. Alternative name: Z-PP-CHO. Purity: ≥97% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.
Abcam Citrate Assay Kit
Citrate Assay Kit
The product is subject to the following: Abcam Restricted Use Statement
Enzo Life Sciences MMP-Inhibitor profiling kit, fluorometric (1x96wells)
A QUANTIZYME Assay System Complete assay system designed to examine the specificity of inhibitors against a panel of ten matrix metalloproteinase enzymes. The assays are performed in a convenient 96-well microplate format using a sensitive fluorogenic substrate . Included are active MMP enzymes, assay buffer, a prototypic control inhibitor (NNGH3), and a detailed instruction booklet. Applications: Fluorescent detection, HTS Activity assay.
Medchemexpress LLC Veratridine | 71-62-5 | 10 MG
Veratridine is a plant neurotoxin and a voltage-gated sodium channel (VGSCs) agonist. It inhibits the peak current of Nav1.7 with an IC50 of 18.39 μM. It regulates sodium ion channels by activating them, preventing channel inactivation, and increasing sodium ion flow. This product is for research use only.
- Plant neurotoxin
- Voltage-gated sodium channels (VGSCs) agonist
- Inhibits peak current of Nav1.7
- Regulates sodium ion channels by activation
- Prevents channel inactivation
- Increases sodium ion flow
Medchemexpress LLC Tulobuterol (C-78 free base) | 41570-61-0 | 99.7% | 50 MG
Tulobuterol (C-78 free base) is a long-acting β2-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. It is also a sympathomimetic agent used as a transdermal patch, and increases normal diaphragm muscle strength.
- Decreases RV14 RNA levels at 1 day and 3 days after infection in human tracheal epithelial cells.
- Significantly lowers sICAM-1 concentrations in cell supernatants.
- Reduces the number and fluorescence intensity of acidic endosomes.
- Decreases RV14 infection-induced secretion of IL-1β, IL-6, and IL-8.
- Produces a small but significant reduction in p50, p65, and c-Rel of NF-κB induced by RV14 infection.
- Maintains diaphragm muscle contractility for over 24 hours in a mouse model of sepsis.
Echelon Biosciences Research Labs BODIPY FL PI(3)P 100 ug
BODIPY FL PI(3)P (BODIPY FL Phosphatidylinositol 3-phosphate) is a water soluble analog of PI(3)P labeled with the green fluorophore, Bodipy-FL at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3-phosphate is enriched in early endosomes having roles in endosome fusion and receptor sorting and internalization in multivesicular bodies. PI(3)P has also been found at the plasma membrane and is involved in the translocation of the glucose transport protein GLUT4. This item is non returnable
Enzo Life Sciences Sulindac sulfide (25mg). CAS: 32004-67-4
Active metabolite of sulindac (ALX-430-105). Inhibits cyclooxygenase. More selective for PGHS-1 (ID50=0.5 µM) over PGHS-2 (ID50=14 µM). Induces apoptosis by a cyclooxygenase-independent mechanism. Inhibits colorectal cancer growth and γ-secretase. NF-κB inhibitor. Inhibits Ras signaling. Alternative name: Z-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid. Purity: ≥99% (TLC). Solubility: Soluble in DMSO (>25mg/ml) or 100% ethanol (5mg/ml, warm). Long Term Storage: Ambient.
Echelon Biosciences Research Labs 3S-PTDINS(3,4,5)P3 DIC16 500 ug
PtdIns(3,4,5)P3 3-phosphothioate, diC16 (3S-PtdIns(3,4,5)P3, diC16) is a water-soluble, synthetic PI(3,4,5)P3 analog in which the 3-phosphate has been rendered metabolically stable as a phosphorothioate. P-3S908 shows 90% inhibition of PTEN at 0.4M. This item is non returnable
Echelon Biosciences Research Labs EICOSANOYL LPA 1 mg
Arachidoyl LPA, 20:0 LPA (aka Eicosanoyl LPA) is an analog of lysophosphatidic acid (LPA), a lysophospholipid involved in cell proliferation. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation, chemotaxis, platelet aggregation, wound healing, angiogenesis, tumor invasion, and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer, LPA primarily promotes cell survival, migration and invasion. May contain up to 5-10% of the 2-acyl isomer due to acyl transfer. This item is non returnable
Selleck Chemical LLC 6-Methylcoumarin S4802-25mg
6-Methylcoumarin (Toncarine) a synthetic fragrance widely used in cosmetics belongs to the class of organic compounds known as coumarins and derivatives
Enzo Life Sciences Salubrinal (1mg). CAS: 405060-95-9
Cell permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Protects ER stress-induced apoptosis (EC50~15µM in PC12 cells stimulated with 750ng/ml of tunicamycin (BML-CC104)). Purity: ≥98% (HPLC(UV)). Solubility: Soluble in DMSO (300 mg/ml), dioxane (0.5 mg/ml), methanol (5 mg/ml) or acetonitrile (1.5 mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences (±)-Verapamil . hydrochloride (5g). CAS: 152-11-4
Blocks slow voltage-sensitive L-type Ca2+ channels. Adrenergic antagonist. Inhibits platelet-activating factor and PMA-stimulated prostaglandin production in Kupffer cells. Induces apoptosis. In vitro resistance modifier in drug resistant human tumor cell lines. Alternative name: 5-[(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropyl-valeronitrile . HCl. Purity: ≥99% (HPLC). Appearance: White crystalline powder. Solubility: Soluble in 100% ethanol (26mg/ml), methanol or water (83mg/ml). Long Term Storage: Ambient.
Enzo Life Sciences Mca-RPPGFSAFK(Dnp) (1 mg)
Protease substrate. Fluorogenic substrate for ECE-1 and ECE-2, ACE1 and ACE2, neprilysin, MMP-2 and MMP-9, thimet oligopeptidase, as well as cathepsin A, cathepsin X/Z, BACE, and insulinase, but not MMP-1.Mca fluorescence is quenched by the Dnp group until cleavage separates them. Ex.: 328nm, Em.: 393nm, although the following Ex/Em have also been used: 320-340/400-420. This substrate is useful for inhibitor screening and kinetic analysis. MW: 1388.5. Formulation: Lyophilized. Purity: ≥98% (HPLC). Sequence Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-OH[Mca=(7-methoxycoumarin-4-yl)acetyl;Dnp=2,4-dinitrophenyl]. Appearance: White to off-white solid. Solubility: Soluble in DMSO to at least 10mM. Long Term Storage: -20°C. Use/Stability: Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. Handling: Protect from light and moisture.