Signal Transduction Reagents and Kits
Enzo Life Sciences (±)-Verapamil . hydrochloride (5g). CAS: 152-11-4
Blocks slow voltage-sensitive L-type Ca2+ channels. Adrenergic antagonist. Inhibits platelet-activating factor and PMA-stimulated prostaglandin production in Kupffer cells. Induces apoptosis. In vitro resistance modifier in drug resistant human tumor cell lines. Alternative name: 5-[(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropyl-valeronitrile . HCl. Purity: ≥99% (HPLC). Appearance: White crystalline powder. Solubility: Soluble in 100% ethanol (26mg/ml), methanol or water (83mg/ml). Long Term Storage: Ambient.
Enzo Life Sciences Salubrinal (1mg). CAS: 405060-95-9
Cell permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Protects ER stress-induced apoptosis (EC50~15µM in PC12 cells stimulated with 750ng/ml of tunicamycin (BML-CC104)). Purity: ≥98% (HPLC(UV)). Solubility: Soluble in DMSO (300 mg/ml), dioxane (0.5 mg/ml), methanol (5 mg/ml) or acetonitrile (1.5 mg/ml). Long Term Storage: -20°C.
Medchemexpress LLC UK122 TFA | 940290-58-4 | 99.85% | 405.33 | 100 MG
UK122 TFA is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM. It exhibits minimal or no inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC50 >100 μM). This 4-oxazolidinone analogue acts as an anticancer agent that hinders cancer cell migration and invasion. This product is intended for research use only.
- Potent and selective uPA inhibitor
- Inhibits cancer cell migration and invasion
- Minimal inhibition of tPA, plasmin, thrombin, and trypsin
- Suitable for in vitro studies
Medchemexpress LLC Reticuline | 485-19-8 | 329.39 | 5 MG
Reticuline demonstrates anti-inflammatory effects by influencing the JAK2/STAT3 and NF-κB signaling pathways. It decreases the mRNA expression of TNF-α and IL-6, and reduces the phosphorylation levels of JAK2 and STAT3. Additionally, Reticuline exhibits cardiovascular effects.
- Inhibits mRNA expressions of TNF-α and IL-6.
- Reduces phosphorylation levels of JAK2 and STAT3.
- Exhibits cardiovascular effects.
- Purity: 98.89%.
- Appearance: Solid, white to yellow.
- For research use only.
Echelon Biosciences Research Labs 1-Hydroxy-2-methyl-2-buten-4-yl 4-diphosphate (HDMAPP) 10 mg
1-Hydroxy-2-methyl-2-buten-4-yl 4-diphosphate (HDMAPP or HMBPP) is an intermediate in the non-mevalonate pathway and is biosynthesized from 2-C-Methyl-D-erythritol 2,4-cyclophosphate (cMEPP) by IspG (GcpE). It is the substrate for IspH (LytB) yielding IPP and DMAPP. In addition, HDMAPP is the most potent VgVd T-cell activator identified. This item is non returnable
Medchemexpress LLC Syk-IN-4 | 2932264-95-2 | 98.0% | C21H25N9O | 10MG
Potent, selective, orally bioavailable spleen tyrosine kinase (SYK) inhibitor with sub-nanomolar potency (IC50 = 0.31 nM). Characterized for in vivo oral exposure and intended for research into autoimmune disorders and hematologic cancers. Supplied as a high-purity white to off-white solid with documented solubility and storage recommendations.
- Sub-nanomolar inhibitory potency against SYK (IC50 = 0.31 nM).
- Orally bioavailable with demonstrated oral exposure in rodent models.
- High purity suitable for biochemical and cellular assays.
- Well-characterized solubility protocols for in vivo formulation.
- Stable under recommended storage conditions.
Quanterix Inc TSA Cyanine 5 Reagent Pack 50-150 Slides
TSA Cyanine 3 (Cy3) reagent pack, for amplification of signal in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols. These reagents amplify by depositing extra Cy5 in the localized area of the probe or antibody.