Signal Transduction Reagents and Kits
Echelon Biosciences Research Labs TNF converting Enzyme Substrate - 5 mg, CAS#: 192723-42-5
TNF converting Enzyme Substrate - 5mg , Mca-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH2 Category/Application: Enzyme Substrates This item is non returnable
Cell Signaling Technology SignalSlide Phospho-ErbB Family IHC Controls 1 Pack
SignalSlide Phospho-ErbB Family IHC Controls 1 Pack
Enzo Life Sciences L-JNKi1 (1mg)
This L-stereoisomer is a cell permeable JNK (c-Jun N-terminal kinase) inhibitor. For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter. Neuroprotective agent for stroke. Inhibits the interaction between JNK (JNK-1, -2 and –3) and its substrate with the same IC50 (in vitro IC50 ~ 1µM), but is degraded more readily than the D-stereoisomer, thus requiring higher treatment concentrations in vitro and in vivo. Alternative name: JNK inhibitor 1 (L-stereoisomer), c Jun N terminal kinase peptide inhibitor 1, L stereoisomer. Purity: ≥95% (HPLC). Formulation: Lyophilized. Solubility: Soluble in water. Long Term Storage: -20°C.
Medchemexpress LLC MC-Val-Cit-PAB-vinblastine | 2055896-92-7 | 99.5% | 1366.62 | C74H97N10O15 | 10 MG
MC-Val-Cit-PAB-vinblastine is a drug-linker conjugate for antibody-drug conjugate (ADC) research that links the microtubule inhibitor vinblastine to a cleavable val-cit-PAB-type linker. It is supplied as a white to light brown solid (CAS 2055896-92-7), with molecular formula C74H97N10O15 and molecular weight 1366.62 g/mol. Intended for research and analytical applications; not for human therapeutic use.
- Drug-linker conjugate designed for ADC research
- Vinblastine payload with microtubule inhibitory activity
- Cleavable linker for lysosomal release
- High purity suitable for analytical applications
- Solid form, white to light brown appearance
- Storage recommendations: 4°C sealed; in solvent -80°C (6 months) or -20°C (1 month)
- Available as a 10 mg pack
Meso Scale Discovery Phos Tyr694TTL STAT5ab WCL20
The Meso Scale Discovery Phospho-Tyr694/Total STAT5A/B Whole Cell Lysate Kit (K15163D) is a kit for detecting phosphorylated STAT5A/B and total STAT5A/B in cell lysates The kit contains a 96-well plate coated with capture antibodies against STAT5A/B and phospho-STAT5A/B Tyr694 It also includes detection antibodies and buffers needed to perform the assay The electrochemiluminescent detection allows for high sensitivity and a broad dynamic range This kit can be used to monitor STAT5A/B phosphorylation and activation in response to cytokines growth factors and drugs that modulate the JAK/STAT pathway It requires a low amount of sample and provides high-quality data
Medchemexpress LLC Allocryptopine | 485-91-6 | 369.41 | 5 MG
Allocryptopine, a derivative of tetrahydropalmatine, is extracted from *Macleaya cordata* (Thunb.) Pers. Papaveraceae. It has antiarrhythmic effects and potently blocks human ether-a-go-go related gene (hERG) current. This product is for research use only.
- Has antiarrhythmic effects.
- Potently blocks human ether-a-go-go related gene (hERG) current.
- Purity: 99.53%.
- Structure classification: alkaloids, isoquinoline alkaloids.
CPC Scientific Ac-Tyr-Val-Lys-Asp-CHO 1MG
Affinity ligand for interleukin-1b converting enzyme. Slow binding caspase-1 (ICE) inhibitor with low selectivity.SEQUENCE: Ac-Tyr-Val-Lys-Asp-CHOONE-LETTER SEQUENCE: Ac-YVKD-CHOMOLECULAR FORMULA: C26H39N5O8MOLECULAR WEIGHT: 549.6STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [147821-01-1]SYNONYMS: RESEARCH AREA: ApoptosisREFERENCES:T.L. Graybill et al., Int. J. Peptide Protein Res., 44, 173 (1994)N.A. Thornbery et al., Nature, 356, 768 (1992)SKU(s): CASP-015A
Enzo Life Sciences SB-216763 (5mg). CAS: 280744-09-4
Potent and selective inhibitor of GSK-3β (IC50=34nM). Stimulates glycogen synthesis in human liver cells and mimics other actions of insulin. Protects primary neurons from death induced by PI-3 kinase pathway inhibition suggesting therapeutic potential in neurodegenerative diseases and stroke. Reduces pulmonary inflammation and fibrosis in a mouse model. Purity: ≥98% (TLC). Solubility: Soluble in DMSO (>25mg/ml). Long Term Storage: Ambient.
Echelon Biosciences Research Labs BODIPY FL-PI(3,5)P2 50 ug
BODIPY FL PI(3,5)P2 (BODIPY FL Phosphatidylinositol 3,5-bisphosphate) is a water soluble analog of PI(3,5)P2 labeled with the green fluorophore, Bodipy-FL at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,5-bisphosphate is in very low abundance and is required for retrograde membrane trafficking from lysosomal and late endosomal compartments to the Golgi and is involved in autophagy. PI(3,5)P2 levels are controlled by the 5-kinase PIKfyve and the 5-phosphatase Fig4/Sac3 and disregulation is linked to several human neuropathies (eg Chacot-Marie-Tooth disease). This item is non returnable
Apexbio Technology LLC vinblastine,10mgCAS# 865-21-4
Extracted from Catharanthus roseus (L.)G.Don;Store the product in sealed, cool and dry condition. Other sizes are also available. Please inqury us for quote.
MilliporeSigma BIOLOGY CHEMISCREEN153 MEMB
Life Sciences,Apoptosis & Cell Biology,ChemiScreen Membrane Preparation Human Recombinant M1 Muscarinic Acetylcholine Receptor
Enzo Life Sciences AMPIPROBE Ureaplasma spp. / M. genitalium / M. hominis Assay Kit (100tests)
The AMPIPROBE Ureaplasma spp. / M. genitalium / M. hominis (UMM) Assay is a real-time polymerase chain reaction (qPCR) assay for the qualitative detection of Ureaplasma spp. (Ureaplasma parvum and Ureaplasma urealyticum), Mycoplasma genitalium, and Mycoplasma hominis DNA. The kit uses the AMPIPROBE assay platform which takes advantage of paired fluorophore- and quencher-labeled primers specific for each of the target species as well as an internal control. The kit contains all reagents necessary for PCR-based detection of Ureaplasma spp., Mycoplasma genitalium, and Mycoplasma hominis DNA. A positive PCR control consisting of a mixture of the target templates and a negative PCR control that results negative for UMM, but positive for the internal control (human β-globin). Please read the complete kit insert before performing this assay. Applications: qPCR. Species reactivity: Mycoplasma hominis, Mycoplasma genitalium, Ureaplasma spp.
Medchemexpress LLC Veratridine (3-Veratroylveracevine) | 71-62-5 | 5 MG
Veratridine is a plant neurotoxin and a voltage-gated sodium channels (VGSCs) agonist. It inhibits the peak current of Nav1.7 with an IC50 of 18.39 μM. Veratridine regulates sodium ion channels by activating them, preventing channel inactivation, and increasing sodium ion flow.
- Acts as a voltage-gated sodium channel agonist.
- Inhibits the peak current of Nav1.7.
- Increases sodium ion flow.
- Prevents channel inactivation.
Neogen Diagnostics K-Blue Luminescent ONE Substrate, 200 ML, HRP, Microwell, Chemiluminescent
K-Blue Luminescent ONE is a stabilized luminescent substrate for use with horseradish peroxidase immunoassays. It contains both luminol and hydrogen peroxide (H2O2) in a one-bottle format with long-term stability, high sensitivity, and excellent signal to noise. Maximal light emission occurs at 430 nm in the presence of peroxidase labeled conjugate. K-Blue Luminescent ONE is compliant with Annex XVII for REACH and contains no hazardous substances at or above published reporting levels. Stable for a minimum of 12-months when stored at 2-8C.
Abcam NFkB p65 Transcription Factor Assay Kit
NFkB p65 Transcription Factor Assay Kit
The product is subject to the following: Abcam Restricted Use Statement