Signal Transduction Reagents and Kits
Selleck Chemical LLC SB202190 (FHPI) 25mg 152121-30-7
SB202190 (FHPI) is a potent p38 MAPK inhibitor targeting p38?/? with IC50 of 50 nM/100 nM in cell-free assays, sometimes used instead of SB 203580 to investigate potential roles for SAPK2a/p38 in vivo. SB202190 inhibits endothelial cell apoptosis via induction of autophagy and heme oxygenase-1. SB202190 significantly suppresses Erastin?dependent ferroptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Echelon Biosciences Research Labs Ins(1,3,4)P3 500 ug
Inositol phosphates are important signaling molecules involved in numerous cellular functions. Inositol 1,3,4-trisphosphate (Ins(1,3,4)P3) is an intermediate in the inositol phosphate pathway. Ins(1,3,4)P3 inhibits Ins(3,4,5,6)P4 1-kinase which regulates Ins(3,4,5,6)P4 levels. Ins(3,4,5,6)P4 in turn is responsible for inhibiting calcium-activated chloride channels. Ins(1,3,4)P3 is produced by dephosphorylation of Ins(1,3,4,5)P4 by a 5-phosphatase. Ins(1,3,4)P3 is a substrate for phosphatases yielding Ins(1,3)P2 and Ins(3,4)P2. This item is non returnable
Echelon Biosciences Research Labs XY-17 (LPA3 Agonist) 0.5 mg
XY-17 is a fluorinated phosphonate analog of lysophosphatidic acid (LPA). XY-17 is not hydrolyzed by lipid phosphate phosphatase (LPP) and acts as an agonist of the LPA3 receptor. This item is non returnable
Echelon Biosciences Research Labs BODIPY FL PI(3)P 100 ug
BODIPY FL PI(3)P (BODIPY FL Phosphatidylinositol 3-phosphate) is a water soluble analog of PI(3)P labeled with the green fluorophore, Bodipy-FL at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3-phosphate is enriched in early endosomes having roles in endosome fusion and receptor sorting and internalization in multivesicular bodies. PI(3)P has also been found at the plasma membrane and is involved in the translocation of the glucose transport protein GLUT4. This item is non returnable
Echelon Biosciences Research Labs PI(5)P DIC8 AMMONIUM SALT 500 ug
Phosphatidylinositol 5-phosphate diC8 (PI(5)P diC8) is a synthetic, purified dioctanoyl PI(5)P.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 5-phosphate (PI(5)P) is a rare lipid found in the nucleus that can bind the PHD finger of the nuclear adapter protein ING2. PI(5)P is phosphorylated to PI(4,5)P2 by Type II PIP kinases. This item is non returnable
Enzo Life Sciences Lysophosphatidic acid, (5mg), CAS Number: 325465-93-8
LPA receptor ligand. Lysophosphatidic acid (LPA) is a multifunctional intercellular phospholipid messenger. LPA stimulates the growth of a variety of cells including fibroblasts, vascular smooth muscle cells, endothelial cells and keratinocytes. It acts as a proliferative and anti-apoptotic factor. Ligand for LPA1 (EDG-2), LPA2 (EDG-4) and LPA3 (EDG-7) receptors. It also inhibits differentiation of neural stem cells into neurons. Alternative Name: 1-Oleoyl-lysophosphatidic acid . sodium salt. Formula: C21H40O7P . Na. MW: 458.5. CAS Number: 325465-93-8. Purity: ≥98% (TLC). Appearance: Waxy solid. Solubility: Soluble in water (5 mg/mL with sonication) or DMSO (0.5 mg/mL warm). Use/Stability: Store as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 1 month. Long Term Storage: -20°C
Abcam Ascorbic Acid Assay Kit (Biological Samples)
Ascorbic Acid Assay Kit (Biological Samples)
The product is subject to the following: Abcam Restricted Use Statement
Enzo Life Sciences STA-21, (1mg), CAS Number: 28882-53-3
STAT inhibitor. STA-21 is a novel Stat3-selective inhibitor. It inhibits Stat3 dimerization and DNA binding as well as Stat3-dependent luciferase reporter activity. Alternative Name: (S)-Ochromycinone, Deoxytetrangomycin. Formula: C19H14O4. MW: 306.3. CAS Number: 28882-53-3. Purity: ≥98% (HPLC). Appearance: White to yellow solid. Solubility: Soluble in DMSO (20mg/ml). Use/Stability: Store solutions at -20°C for up to 3 months. Long Term Storage: -20°C
Sigma Aldrich Fine Chemicals Biosciences Zolmitriptan United States Pharmacopeia (USP) Reference Standard | 139264-17-8 | MFCD00871503 | 200MG
Zolmitriptan United States Pharmacopeia (USP) Reference Standard | Mol Wt: 287.36 | 139264-17-8 | MFCD00871503 | 200MG
Meso Scale Discovery Phos Tyr694TTL STAT5ab WCL 5
The Meso Scale Discovery Phospho-Tyr694/Total STAT5A/B Whole Cell Lysate Kit (K15163D) is a kit for detecting phosphorylated STAT5A/B and total STAT5A/B in cell lysates The kit contains a 96-well plate coated with capture antibodies against STAT5A/B and phospho-STAT5A/B Tyr694 It also includes detection antibodies and buffers needed to perform the assay The electrochemiluminescent detection allows for high sensitivity and a broad dynamic range This kit can be used to monitor STAT5A/B phosphorylation and activation in response to cytokines growth factors and drugs that modulate the JAK/STAT pathway It requires a low amount of sample and provides high-quality data
Medchemexpress LLC Syk-IN-4 | 2932264-95-2 | 98.0% | C21H25N9O | 10MG
Potent, selective, orally bioavailable spleen tyrosine kinase (SYK) inhibitor with sub-nanomolar potency (IC50 = 0.31 nM). Characterized for in vivo oral exposure and intended for research into autoimmune disorders and hematologic cancers. Supplied as a high-purity white to off-white solid with documented solubility and storage recommendations.
- Sub-nanomolar inhibitory potency against SYK (IC50 = 0.31 nM).
- Orally bioavailable with demonstrated oral exposure in rodent models.
- High purity suitable for biochemical and cellular assays.
- Well-characterized solubility protocols for in vivo formulation.
- Stable under recommended storage conditions.
Echelon Biosciences Research Labs SHUTTLE PIP KIT PI(5)P
Echelon Biosciences - Shuttle PIP Kit - P-9005 - PI(5)P This item is non returnable
Echelon Biosciences Research Labs 1-Hydroxy-2-methyl-2-buten-4-yl 4-diphosphate (HDMAPP) 10 mg
1-Hydroxy-2-methyl-2-buten-4-yl 4-diphosphate (HDMAPP or HMBPP) is an intermediate in the non-mevalonate pathway and is biosynthesized from 2-C-Methyl-D-erythritol 2,4-cyclophosphate (cMEPP) by IspG (GcpE). It is the substrate for IspH (LytB) yielding IPP and DMAPP. In addition, HDMAPP is the most potent VgVd T-cell activator identified. This item is non returnable
Echelon Biosciences Research Labs PI(3,4)P2 PolyPIPosomes 0.1 mL
PolyPIPosomes are polymerized liposomes that show markedly increased stability (up to 6 months) vs. conventional liposomes. A biotin tag is incorporated for easy detection of PIPn-binding proteins with streptavidin reagents. PolyPIPosomes are provided as a 1mM total lipid solution containing 5% PIP. Each order of 250 L or 1 mL of PolyPIPosomes includes 100 L of Control PolyPIPosomes. This item is non returnable
![CPC Scientific 4-(4-Dimethylaminophenylazo)benzoyl-Tyr-Val-Ala-Asp-Ala-Pro-Val-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acid 1MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00111436-SUBS-016.PNG-250.jpg)
CPC Scientific 4-(4-Dimethylaminophenylazo)benzoyl-Tyr-Val-Ala-Asp-Ala-Pro-Val-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acid 1MG
SEQUENCE: 4-(4-Dimethylaminophenylazo)benzoyl-Tyr-Val-Ala-Asp-Ala-Pro-Val-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acidONE-LETTER SEQUENCE: 4-(4-Dimethylaminophenylazo)benzoyl-YVADAPV-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acidMOLECULAR FORMULA: C61H76N12O14S1MOLECULAR WEIGHT: 1233.39STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [161877-70-9]SYNONYMS: Caspase 1 (ICE) Substrate; dabcyl-yvadapv-edans; dabcyl-tyr-val-ala-asp-ala-pro-val-edans; ICE Substrate Ii; il-1-beta Converting Enzyme Substrate Ii; il-1b Converting Enzyme Substrate Ii; 4-(4-dimethylaminophenylazo)benzoyl-tyr-val-ala-asp-ala-pro-val-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acid; 4-(4'-dimethylaminophenylazo)benzoyl-tyrosyl-valyl-alanyl-aspartyl-alanyl-prolyl-valyl-5((2-aminoethyl)amino)naphthalene-1-sulfonic acidRESEARCH AREA: ApoptosisREFERENCES:M.W. Pennington et al., Peptide Res., 7, 72 (1994)M. Los et al., Nature 375, 81 (1995)SKU(s): SUBS-016A, SUBS-016B