Signal Transduction Reagents and Kits
Medchemexpress LLC Tulobuterol | 41570-61-0 | MFCD00867022 | 99.7% | 100 MG
Tulobuterol is a long-acting β2-adrenoceptor agonist that helps reduce the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. This sympathomimetic agent is also used as a transdermal patch, increasing normal diaphragm muscle strength. It is intended for research use only.
- Acts as a β2-adrenoceptor agonist
- Reduces RV14 RNA levels and sICAM-1 concentrations in infected cells
- Decreases acidic endosome numbers and fluorescence
- Inhibits RV14 infection-induced secretion of inflammatory cytokines (IL-1β, IL-6, and IL-8)
- Restores and maintains diaphragm muscle contractility
Medchemexpress LLC MC-Val-Cit-PAB-vinblastine | 2055896-92-7 | 99.5% | 1366.62 | C74H97N10O15 | 10 MG
MC-Val-Cit-PAB-vinblastine is a drug-linker conjugate for antibody-drug conjugate (ADC) research that links the microtubule inhibitor vinblastine to a cleavable val-cit-PAB-type linker. It is supplied as a white to light brown solid (CAS 2055896-92-7), with molecular formula C74H97N10O15 and molecular weight 1366.62 g/mol. Intended for research and analytical applications; not for human therapeutic use.
- Drug-linker conjugate designed for ADC research
- Vinblastine payload with microtubule inhibitory activity
- Cleavable linker for lysosomal release
- High purity suitable for analytical applications
- Solid form, white to light brown appearance
- Storage recommendations: 4°C sealed; in solvent -80°C (6 months) or -20°C (1 month)
- Available as a 10 mg pack
Revvity Health Sciences Inc Terbium SureFire Ultra Human Phospho-STAT3 (Tyr705 ) Detection Kit, 10,000 Assay Points
Terbium SureFire Ultra Human Phospho-STAT3 (Tyr705 ) Detection Kit, 10,000 Assay Points
Enzo Life Sciences SB-202190 (1mg). CAS: 152121-30-7
Cell permeable, potent and selective p38 MAP kinase inhibitor (IC50=30 nM). Inhibits p38α and ß, but not γ and δ isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. A useful tool for dissecting the role of p38 in signaling pathways. Induces apoptosis. Alternative name: FHPI, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole. Purity: ≥98% (TLC). Solubility: Soluble in methanol, DMSO or acetone; slightly soluble in ethyl acetate. Long Term Storage: -20°C.
Carnabio Usa Inc CK2A1/B(CSNK2A1/B)/5UG/FULL-LE
CK2a1/b(CSNK2A1/B), Full-length(CK2a1), Wild type, Amino Acid 1-391(CK2a1), 1-215(CK2b), NP_001886.1(CK2a1), NP_001311.3(Ck2b1), Expressed in Insect (sf21); 5microg
Sigma Aldrich Fine Chemicals Biosciences (+)-BICUCULLINE-100MG
(+)-Bicuculline, 100MG, CAS# 485-49-4, MFCD00005006, MOLWT: 367.35
Medchemexpress LLC Allocryptopine | 485-91-6 | 369.41 | 5 MG
Allocryptopine, a derivative of tetrahydropalmatine, is extracted from *Macleaya cordata* (Thunb.) Pers. Papaveraceae. It has antiarrhythmic effects and potently blocks human ether-a-go-go related gene (hERG) current. This product is for research use only.
- Has antiarrhythmic effects.
- Potently blocks human ether-a-go-go related gene (hERG) current.
- Purity: 99.53%.
- Structure classification: alkaloids, isoquinoline alkaloids.
Hach Company General Purpose Contacting Conductivity Sensor, Ryton Body, K=10.0 Cell Constant
Nominal Cell Constant (K) = 10.0, 3/4 inch male NPT threaded Ryton body, 6m (20ft) Analog Cable, Graphite Electrode
Echelon Biosciences Research Labs PI(4)P DIC8 AMMONIUM 500 ug
Phosphatidylinositol 4-phosphate diC8 (PI(4)P diC8) is a synthetic, purified dioctanoyl PI(4)P.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4-phosphate (PI(4)P) is the biosynthetic precursor to PI(4,5)P2 and has an important roles in regulating sphingomyelin and glycosphingolipid metabolism and membrane trafficking at the exit of the Golgi complex. This item is non returnable
Sigma Aldrich Fine Chemicals Biosciences Calpeptin >=98% (HPLC) | 117591-20-5 | MFCD00155623 | 25MG
Calpeptin >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 362.46 | 117591-20-5 | MFCD00155623 | 25MG
Enzo Life Sciences Matrix Metalloproteinase-14 (MMP-14) colorimetric drug discovery kit (1x96wells)
A QUANTIZYME Assay System. The MMP-14 Colorimetric Drug Discovery Kit is a complete assay sytem designed to screen for inhibitors of matrix metalloproteinase-14 (MMP-14, membrane-type matrix metalloproteinase 1, MT1-MMP) using a thiopeptide as a chromogenic substrate. The assays are performed in a convenient 96-well plate format. Also included are active enzyme, a prototypic control inhibitor (NNGH), and a detailed instruction booklet. Alternative name: Membrane type matrix metalloproteinase 1, MT-1 MMP. Applications: Colorimetric detection, HTS Activity assay.
CPC Scientific Ac-Tyr-Val-Lys-Asp-CHO 1MG
Affinity ligand for interleukin-1b converting enzyme. Slow binding caspase-1 (ICE) inhibitor with low selectivity.SEQUENCE: Ac-Tyr-Val-Lys-Asp-CHOONE-LETTER SEQUENCE: Ac-YVKD-CHOMOLECULAR FORMULA: C26H39N5O8MOLECULAR WEIGHT: 549.6STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [147821-01-1]SYNONYMS: RESEARCH AREA: ApoptosisREFERENCES:T.L. Graybill et al., Int. J. Peptide Protein Res., 44, 173 (1994)N.A. Thornbery et al., Nature, 356, 768 (1992)SKU(s): CASP-015A
Neogen Diagnostics K-Blue Luminescent Substrate, 500 ML, HRP, Microwell, Chemiluminescent
K-Blue Luminescent is a stabilized luminescent substrate for use with horseradish peroxidase immunoassays. It contains both luminol and hydrogen peroxide (H2O2) in a two-bottle format with long-term stability, high sensitivity, and excellent signal to noise. Maximal light emission occurs at 430 nm in the presence of peroxidase labeled conjugate. K-Blue Luminescent is compliant with Annex XVII for REACH and contains no hazardous substances at or above published reporting levels. Stable for a minimum of 18-months when stored at 2-8C.
Medchemexpress LLC UK122 TFA | 940290-58-4 | 99.85% | 405.33 | 100 MG
UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM. It exhibits minimal inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC50 >100 μM). This 4-oxazolidinone analogue acts as an anticancer agent by inhibiting cancer cell migration and invasion.
- Dose-dependently inhibits cell migration
- Significantly reduces invasiveness of CFPAC-1 cells
- Does not affect cell growth or cell morphology in CFPAC-1 cells at certain concentrations
- Appears as a white to yellow solid
- Recommended for research use only
Enzo Life Sciences SB-216763 (5mg). CAS: 280744-09-4
Potent and selective inhibitor of GSK-3β (IC50=34nM). Stimulates glycogen synthesis in human liver cells and mimics other actions of insulin. Protects primary neurons from death induced by PI-3 kinase pathway inhibition suggesting therapeutic potential in neurodegenerative diseases and stroke. Reduces pulmonary inflammation and fibrosis in a mouse model. Purity: ≥98% (TLC). Solubility: Soluble in DMSO (>25mg/ml). Long Term Storage: Ambient.