Signal Transduction Reagents and Kits
Medchemexpress LLC Allocryptopine | 485-91-6 | 369.41 | 5 MG
Allocryptopine, a derivative of tetrahydropalmatine, is extracted from *Macleaya cordata* (Thunb.) Pers. Papaveraceae. It has antiarrhythmic effects and potently blocks human ether-a-go-go related gene (hERG) current. This product is for research use only.
- Has antiarrhythmic effects.
- Potently blocks human ether-a-go-go related gene (hERG) current.
- Purity: 99.53%.
- Structure classification: alkaloids, isoquinoline alkaloids.
Enzo Life Sciences Matrix Metalloproteinase-14 (MMP-14) colorimetric drug discovery kit (1x96wells)
A QUANTIZYME Assay System. The MMP-14 Colorimetric Drug Discovery Kit is a complete assay sytem designed to screen for inhibitors of matrix metalloproteinase-14 (MMP-14, membrane-type matrix metalloproteinase 1, MT1-MMP) using a thiopeptide as a chromogenic substrate. The assays are performed in a convenient 96-well plate format. Also included are active enzyme, a prototypic control inhibitor (NNGH), and a detailed instruction booklet. Alternative name: Membrane type matrix metalloproteinase 1, MT-1 MMP. Applications: Colorimetric detection, HTS Activity assay.
BPS Bioscience Inc NFAT EGFP REPORTER LENTIVIRUS
The NFAT eGFP Reporter Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. BPS BIOSCIENCE INC mfg# 79922
LifeSensors Linkage Profiling UbiTest – Agarose TUBE Elution Kit
The UbiTest kit determines whether a target protein is polyubiquitinated and improves on traditional immunoprecipitation–Western blot methods, which often fail due to epitope masking, reduced antibody affinity, or altered selectivity. By combining immunoprecipitation with broad‑spectrum DUB digestion, the assay reveals increased signal for the protein of interest after DUB treatment, confirming ubiquitination even when untreated samples show weak or no detection. To avoid antibody‑dependent variability, UbiTest uses TUBEs to pull down polyubiquitinated proteins, leveraging their nanomolar affinity and ability to bind all eight linkage types. For linkage determination, LifeSensors employs linkage‑specific DUBs; an increased unmodified band after K48‑ or K63‑specific DUB treatment indicates the protein carries those linkage types.
Aat Bioquest Calbryte™ 520 AM | 2x50ug
The intracellular calcium flux assay is a widely used method in monitoring signal transduction pathways and high throughput screening of G protein"coupled receptors (GPCRs) and calcium channel targets. Followed by Fluo-3 being introduced in 1989, Fluo-4, Fluo-8 and Cal-520 were later developed with improved signal/background ratio, and became the widely used Ca2+ indicators for confocal microscopy, flow cytometry and high throughput screening applications. However, there are still a few severe problems with Fluo-4. For example, as for Fluo-3, in all most all the intracellular calcium assays with Fluo-4 AM, probenecid is required to prevent the cell-loaded Fluo-4 from leaking out of cells. The use of probenecid with Fluo-4-based calcium assays compromises the assay results since probenecid is well-documented to have a variety of complicated cellular effects. Calbryte™ 520, AM is a novel fluorescent and cell-permeable indicator for the measurement of intracellular calcium.
MilliporeSigma BIOLOGY CHEMISCREEN153 MEMB
Life Sciences,Apoptosis & Cell Biology,ChemiScreen Membrane Preparation Human Recombinant M1 Muscarinic Acetylcholine Receptor
Medchemexpress LLC UK122 TFA | 940290-58-4 | 99.85% | 405.33 | 100 MG
UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM. It exhibits minimal inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC50 >100 μM). This 4-oxazolidinone analogue acts as an anticancer agent by inhibiting cancer cell migration and invasion.
- Dose-dependently inhibits cell migration
- Significantly reduces invasiveness of CFPAC-1 cells
- Does not affect cell growth or cell morphology in CFPAC-1 cells at certain concentrations
- Appears as a white to yellow solid
- Recommended for research use only
![CPC Scientific 4-(4-Dimethylaminophenylazo)benzoyl-Tyr-Val-Ala-Asp-Ala-Pro-Val-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acid 0.5MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00111436-SUBS-016.PNG-250.jpg)
CPC Scientific 4-(4-Dimethylaminophenylazo)benzoyl-Tyr-Val-Ala-Asp-Ala-Pro-Val-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acid 0.5MG
SEQUENCE: 4-(4-Dimethylaminophenylazo)benzoyl-Tyr-Val-Ala-Asp-Ala-Pro-Val-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acidONE-LETTER SEQUENCE: 4-(4-Dimethylaminophenylazo)benzoyl-YVADAPV-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acidMOLECULAR FORMULA: C61H76N12O14S1MOLECULAR WEIGHT: 1233.39STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [161877-70-9]SYNONYMS: Caspase 1 (ICE) Substrate; dabcyl-yvadapv-edans; dabcyl-tyr-val-ala-asp-ala-pro-val-edans; ICE Substrate Ii; il-1-beta Converting Enzyme Substrate Ii; il-1b Converting Enzyme Substrate Ii; 4-(4-dimethylaminophenylazo)benzoyl-tyr-val-ala-asp-ala-pro-val-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acid; 4-(4'-dimethylaminophenylazo)benzoyl-tyrosyl-valyl-alanyl-aspartyl-alanyl-prolyl-valyl-5((2-aminoethyl)amino)naphthalene-1-sulfonic acidRESEARCH AREA: ApoptosisREFERENCES:M.W. Pennington et al., Peptide Res., 7, 72 (1994)M. Los et al., Nature 375, 81 (1995)SKU(s): SUBS-016A, SUBS-016B
Cell Biolabs Inc PhosphoBLOCKER™ Blocking Reagent, 50 g dry blend (1 Liter prepared)
The utilization of anti-phosphoprotein antibodies in western blotting has become a commonly used tool for signal transduction research. Unfortunately, low levels of endogenous phosphoprotein in various cell lysates often can not be detected, even with high concentrations of antibody and long exposure times. Most commercially available western blot blockers (e.g. dry milk, serum) are sufficient to block the unreacted sites on the membrane, reducing the amount of nonspecific antibody binding during the assay; however, they are not designed to preserve phosphoprotein antigens during blotting. Cell Biolabs’ PhosphoBLOCKER™ contains a proprietary formulation that provides several advantages over conventional blockers: (1) It is designed specifically for phosphoprotein blotting; (2) It enhances low level phosphoprotein signal without increasing background; and (3) it is an easy to use premixed dry blend. 50 grams (reconstituted to 1 liter).
Montana Molecular Green Downward GENIe cGMP Sensor Kit D0800G, 30mL, CMV
Measure cyclic GMP (cGMP) signaling dynamics and ascertain the specificity of PDE inhibitors or SNP activators with this live cell fluorescent assay. Add GENIe to your cells and measure robust signals the next day on an automated plate reader or fluorescence imaging system. Decreasing green fluorescence indicates cGMP increase. The assay is genetically encoded and packaged in BacMam for efficient transduction in most cell types - including uniform and near 100% efficiency in HEK293 cells as well as expression in many primary or iPSC-derived cells. Kit includes soluble guanylate cyclase..
Medchemexpress LLC Tulobuterol | 41570-61-0 | MFCD00867022 | 99.7% | 100 MG
Tulobuterol is a long-acting β2-adrenoceptor agonist that helps reduce the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. This sympathomimetic agent is also used as a transdermal patch, increasing normal diaphragm muscle strength. It is intended for research use only.
- Acts as a β2-adrenoceptor agonist
- Reduces RV14 RNA levels and sICAM-1 concentrations in infected cells
- Decreases acidic endosome numbers and fluorescence
- Inhibits RV14 infection-induced secretion of inflammatory cytokines (IL-1β, IL-6, and IL-8)
- Restores and maintains diaphragm muscle contractility
Enzo Life Sciences (2R,4R)-APDC (1mg). CAS: 169209-63-6
Selective agonist for group II mGluRs. Inhibits the NADPH-oxidase dependent ROS system. Alternative name: LY-314,593, (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid. Purity: ≥98% (HPLC). Solubility: Soluble in water. Long Term Storage: Ambient.
Selleck Chemical LLC SB202190 (FHPI) 100mg 152121-30-7
SB202190 (FHPI) is a potent p38 MAPK inhibitor targeting p38?/? with IC50 of 50 nM/100 nM in cell-free assays, sometimes used instead of SB 203580 to investigate potential roles for SAPK2a/p38 in vivo. SB202190 inhibits endothelial cell apoptosis via induction of autophagy and heme oxygenase-1. SB202190 significantly suppresses Erastin?dependent ferroptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Echelon Biosciences Research Labs 1-Hydroxy-2-methyl-2-buten-4-yl 4-diphosphate (HDMAPP) 1 mg
1-Hydroxy-2-methyl-2-buten-4-yl 4-diphosphate (HDMAPP or HMBPP) is an intermediate in the non-mevalonate pathway and is biosynthesized from 2-C-Methyl-D-erythritol 2,4-cyclophosphate (cMEPP) by IspG (GcpE). It is the substrate for IspH (LytB) yielding IPP and DMAPP. In addition, HDMAPP is the most potent VgVd T-cell activator identified. This item is non returnable
Sigma Aldrich Fine Chemicals Biosciences Calpeptin >=98% (HPLC) | 117591-20-5 | MFCD00155623 | 25MG
Calpeptin >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 362.46 | 117591-20-5 | MFCD00155623 | 25MG