Custom Enzymes and Inhibitors
Selleck Chemical LLC SU11274 25mg 658084-23-2 PKI-SU11274
SU11274 (PKI-SU11274) is a selective Met (c-Met) inhibitor with IC50 of 10 nM in cell-free assays, no effects on PGDFR?, EGFR or Tie2. SU11274 induces autophagy, apoptosis and cell cycle arrest. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Resveratrol 500mg 501-36-0
Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 ?M), lipooxygenases(LOX, IC50=2.7 ?M), kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC 2-(3-mercaptopropyl)pentanedioic acid | 254737-29-6 | MFCD24479659 | 98.0% | 206.26 g/mol | C8H14O4S | 5 MG
2-(3-mercaptopropyl)pentanedioic acid is an orally active, selective inhibitor of glutamate carboxypeptidase II (GCP II/NAALADase) used in biochemical and in vivo pharmacology research. It is supplied as a small-molecule standard for laboratory studies and is characterized by a thiol-containing structure that confers oral bioavailability.
Selleck Chemical LLC SB525334 10mg 356559-20-1
SB525334 is a potent and selective inhibitor of TGF? receptor I (ALK5) with IC50 of 14.3 nM in a cell-free assay, 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC SB525334 100mg 356559-20-1
SB525334 is a potent and selective inhibitor of TGF? receptor I (ALK5) with IC50 of 14.3 nM in a cell-free assay, 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Quizartinib (AC220) 50mg 950769-58-1
Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM in MV4-11 and RS4;11 cells, respectively, 10-fold more selective for Flt3 than KIT, PDGFR?, PDGFR?, RET, and CSF-1R. Quizartinib (AC220) induces apoptosis of tumor cells. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC YM155 (Sepantronium Bromide) 100mg 781661-94-7
YM155 (Sepantronium Bromide) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM in HeLa-SURP-luc and CHO-SV40-luc cells; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Elvitegravir (JTK-303) 10mg 697761-98-1 GS-9137
Elvitegravir (GS-9137, JTK-303) is an HIV integrase inhibitor for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM in cell-free assays, respectively. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Everolimus (RAD001) 25mg 159351-69-6
Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM in a cell-free assay. Everolimus induces cell apoptosis and autophagy and inhibits tumor cells proliferation. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Belinostat (PXD101) 50mg 414864-00-9 NSC726630, PX-105684
Belinostat (PXD101, NSC726630, PX-105684) is a novel HDAC inhibitor with IC50 of 27 nM in a cell-free assay, with activity demonstrated in cisplatin-resistant tumors. Belinostat (PXD101) induces autophagy. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC SB216763 5mg 280744-09-4
SB216763 is a potent and selective GSK-3 inhibitor with IC50 of 34.3 nM for GSK-3? and equally effective at inhibiting human GSK-3?. SB216763 activates autophagy. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC SNS-314 5mg 1057249-41-8
SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Roscovitine (Seliciclib) 50mg 186692-46-6 CYC202
Roscovitine (Seliciclib, CYC202) is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 ?M, 0.7 ?M and 0.16 ?M in cell-free assays. It shows little effect on CDK4/6. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Abexinostat (PCI-24781) 50mg 783355-60-2 CRA-024781
Abexinostat (PCI-24781, CRA-024781) is a novel pan-HDAC inhibitor mostly targeting HDAC1 with Ki of 7 nM, modest potent to HDACs 2, 3, 6, and 10 and greater than 40-fold selectivity against HDAC8. Phase 1/2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Temsirolimus (CCI-779) 50mg 162635-04-3 NSC 683864
Temsirolimus (CCI-779, NSC 683864) is a specific mTOR inhibitor with IC50 of 1.76 ?M in a cell-free assay. Temsirolimus induces autophagy and apoptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.