Custom Enzymes and Inhibitors
Enzo Life Sciences Mu-Phe-hPhe-FMK (1mg)
Irreversible, non-toxic, cell-permeable inhibitor of cysteine proteases calpain, cathepsins B and L, and Trypanosome trypanopain. Can be used in vitro (typically 20 µM) or in vivo. Inhibits tumor formation and growth. Alternative name: N-Morpholineurea-phenylalanyl-homophenylalanylfluoromethyl ketone. Purity: ≥98% (TLC). Solubility: Soluble in DMSO (>25 mg/ml). Long Term Storage: +4°C.
Selleck Chemical LLC Posaconazole 25mg 171228-49-2 SCH56592
Posaconazole (SCH56592) is an inhibitor primarily of CYP3A4, but it does not inhibit the activity of other CYP enzymes; Also an inhibitor of sterol C14? demethylase inhibitor with IC50 of 0.25 ?M. Posaconazole has a median terminal elimination half-life of 15-35 hours. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC SB-612111 hydrochloride | 371980-98-2 | 99.64% | 454.86 | 5 MG
SB-612111 hydrochloride is a novel and potent opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 (Ki=0.33 nM). It exhibits selectivity for μ-, κ- and δ-receptors with Ki values of 57.6 nM, 160.5 nM, and 2109 nM, respectively. It effectively antagonizes the pronociceptive action of Nociceptin in an acute pain model.
- ORL-1 inhibitor
- Effectively antagonizes the pronociceptive action of nociceptin in an acute pain model
- Appearance: Solid
- Color: White to off-white
Selleck Chemical LLC Luminespib (NVP-AUY922) 25mg 747412-49-3 AUY-922
Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90?/? with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Luminespib (AUY-922, NVP-AUY922) effectively downregulates and destabilizes the IGF-1R? protein and results in growth inhibition, autophagy and apoptosis. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Tepotinib | 1100598-32-0 | 99.9% | 492.57 | 5 MG
Tepotinib (EMD-1214063) is an orally active, highly selective, reversible, ATP-competitive c-Met inhibitor. It is >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer. Tepotinib inhibits c-Met phosphorylation, induces autophagy, and exhibits antitumor effects.
- Highly selective c-Met inhibitor
- Orally active
- Reversible and ATP-competitive
- Inhibits c-Met phosphorylation
- Induces autophagy
- Exhibits antitumor effects
Apexbio Technology LLC Y-27632, 146986-50-7, MFCD03093855, 10 mg
MF: C14H21N3O, MW: 247.34, Solubility: 24.7mg/mL in DMSO,insoluble in Chloroform. Y-27632 is a specific inhibitor of Rho-associated kinases(ROCK) family with Ki values of 0.22uM and 0.30uM for ROCK1 and ROCK2, respectively.
Selleck Chemical LLC Roscovitine (Seliciclib) 200mg 186692-46-6 CYC202
Roscovitine (Seliciclib, CYC202) is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 ?M, 0.7 ?M and 0.16 ?M in cell-free assays. It shows little effect on CDK4/6. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC GSK429286A 50mg 864082-47-3 RHO-15
GSK429286A (RHO-15) is a selective inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 63 nM, respectively. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC OSU-03012 (AR-12) 25mg 742112-33-0
OSU-03012 (AR-12) is a potent inhibitor of recombinant PDK-1(phosphoinositide-dependent kinase 1) with IC50 of 5 ?M in a cell-free assay and 2-fold increase in potency over OSU-02067. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC XAV-939 10mg 284028-89-3 NVP-XAV939
XAV-939 (NVP-XAV939) selectively inhibits Wnt/?-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM in cell-free assays, regulates axin levels and does not affect CRE, NF-?B or TGF-?. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Pfaltz & Bauer Hyaluronidase lyophilized powder bovine minimum 300 units/mg, 100mg
Hyaluronidase lyophilized powder bovine minimum 300 units/mg, 37326-33-3, MFCD00131351. 55 kDa, 100mg
Cederlane FSG67 Inhibitor of Glycerol 3-Phosphate Acyltransferase. 10mg
Inhibitor of Glycerol 3-Phosphate Acyltransferase. 10mg. CAS: 1158383-34-6; 98% by TLC NMR (Conforms) Focus Biomolecules Catalog# 10-4577.
Medchemexpress LLC Abt-724 trihydrochloride | 587870-77-7 | MFCD08703101 | 99.1% | 402.75 g/mol | C17H22Cl3N5 | 25 MG
ABT-724 trihydrochloride is a research-grade small molecule dopamine D4 receptor agonist supplied as the trihydrochloride salt. It is intended for pharmacology and neuroscience research and is provided as a high-purity solid.
- Potent and selective dopamine D4 receptor agonist (EC50 12.4 nM).
- High purity (~99.1% by HPLC).
- Molecular weight 402.75 g/mol; formula C17H22Cl3N5.
- Supplied as a 25 mg research reagent.
- Appearance: solid; store sealed and away from moisture.
- In solvent stability: -80°C (up to 6 months), -20°C (up to 1 month).
Athens Research And Technology Inc C1 ESTERASE INHIBITOR 1MG
C-1 Esterase Inhibitor, Human Plasma: 1 MG; Frozen in 20 mM potassium phosphate, pH 7.0, with 250 mM potassium chloride; MW 100,000; EC=0.4; Purity: > =95% by SDS-PAGE. This protein is prepared and purified from human plasma.
Medchemexpress LLC Abt-724 trihydrochloride | 587870-77-7 | 99.1% | 402.75 g/mol | C17H22Cl3N5 | 50 MG
ABT-724 trihydrochloride is a potent, selective dopamine D4 receptor agonist supplied as a white to off-white solid for research use. It shows low-nanomolar activity at human D4 receptors (EC50 12.4 nM) and has been investigated for potential treatment of erectile dysfunction. Store sealed and away from moisture; in solution, store at -80°C (up to 6 months) or -20°C (up to 1 month).
- High purity suitable for research applications.
- Potent dopamine D4 receptor agonist with low-nanomolar EC50.
- White to off-white solid, easy to handle.
- Available in multiple package sizes to suit experiments.
- Stable when stored sealed; follow recommended temperature guidelines.