Custom Enzymes and Inhibitors
Selleck Chemical LLC Daptomycin 20mg 103060-53-3 LY146032
Daptomycin (LY146032) is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC BI 2536 50mg 755038-02-9
BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Ethyl 2-(4-((2-amino-4-oxothiazol-5(4H)-ylidene)methyl)-2-methoxyphenoxy)acetate | 939228-52-1 | 98.5% | 25MG
Ethyl 2-(4-((2-amino-4-oxothiazol-5(4H)-ylidene)methyl)-2-methoxyphenoxy)acetate | 939228-52-1 | 98.5% | 25MG
Selleck Chemical LLC NVP-AEW541 10mg 475489-16-8 AEW541
NVP-AEW541 is a potent inhibitor of IGF-1R/InsR with IC50 of 150 nM/140 nM in cell-free assays, greater potency and selectivity for IGF-1R in a cell-based assay. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC SNS-032 (BMS-387032) 5mg 345627-80-7
SNS-032 (BMS-387032) has firstly been described as a selective inhibitor of CDK2 with IC50 of 48 nM in cell-free assays and is 10- and 20-fold selective over CDK1/CDK4. It is also found to be sensitive to CDK7/9 with IC50 of 62 nM/4 nM, with little effect on CDK6. SNS-032 (BMS-387032) induces apoptosis. Phase 1. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC XAV-939 50mg 284028-89-3 NVP-XAV939
XAV-939 (NVP-XAV939) selectively inhibits Wnt/?-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM in cell-free assays, regulates axin levels and does not affect CRE, NF-?B or TGF-?. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC CCI-006 5mg | 292053-42-0 | 5 MG
CCI-006 is a research-grade small molecule that inhibits mitochondrial respiration and acts as a chemosensitizer in MLL-rearranged leukemia cells. Supplied as a high-purity solid for in vitro research use only.
- High purity suitable for in vitro studies.
- Molecular weight 332.33 g/mol.
- Molecular formula C15H12N2O5S.
- Light yellow to yellow solid physical form.
- Intended for laboratory research use, not for human or diagnostic use.
Selleck Chemical LLC PLX-4720 10mg 918505-84-7
PLX4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), 10-fold selectivity for B-RafV600E than wild-type B-Raf. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Enzo Life Sciences GYY 4137 (50mg). CAS: 106740-09-4
Water-soluble, slow-releasing hydrogen sulfide (H2S) donor. Shows vasodilator and antihypertensive activity in rats in both acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models. Inhibits LPS-induced release of various proinflammatory mediators (such as IL-1β, IL-6, TNF-α, nitric oxide (NO) and PGE2) in RAW264.7 cells. Increases the synthesis of the anti-inflammatory chemokine IL-10 through NF-κB, ATF-2 and HSP27 dependent pathways in RAW264.7 cells. Alternative name: 4-Methoxyphenyl(morpholino)phosphinodithioate morpholinium salt, Lawesson. Purity: ≥95%. Solubility: Soluble in water (30mg/ml) or DMSO (15mg/ml). Long Term Storage: -20°C.
Medchemexpress LLC HY-103409 10mg Medchemexpress, ABT-724 (trihydrochloride) CAS:587870-77-7 Purity:>98%
Medchemexpress, HY-103409 10mg ABT-724 (triHCl) CAS:587870-77-7 ABT-724 trihydrochloride is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 trihydrochloride is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM), and has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 trihydrochloride could be useful for the treatment of erectile dysfunction and has favorable side-effect profile. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC CCI-006 100mg | 292053-42-0 | 100 MG
CCI-006 is a small-molecule inhibitor of mitochondrial metabolism that functions as a chemosensitizer in MLL-rearranged leukemia models. Supplied as a high-purity solid, it is intended for research use only.
- Selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells.
- Molecular formula: C15H12N2O5S.
- Molecular weight: 332.33 g·mol-1.
- High purity (reported 99.87%).
- Physical form: solid powder.
- Recommended storage: powder at -20°C or 4°C; in solvent at -80°C.
- Intended for research use only; not for human consumption.
Medchemexpress LLC Amxi-5001 | 2170491-77-5 | MFCD34676674 | 98.3% | 457.46 | C25H20FN5O3 | 5 MG
AMXI-5001 is a small-molecule research compound described as a potent, orally active dual PARP1/2 and microtubule polymerization inhibitor with selective antitumor cytotoxicity in multiple human cancer cell lines; it has demonstrated tumor regression in preclinical studies.
- Potent dual PARP1/2 and microtubule polymerization inhibition.
- Selective antitumor cytotoxicity across various human cancer cell lines.
- High purity suitable for research applications.
- Soluble in DMSO at 50 mg/mL with warming and sonication recommended.
- Stable as a powder when stored at -20°C for long-term storage.
Selleck Chemical LLC Alisertib (MLN8237) 50mg 1028486-01-2
Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay. It has >200-fold higher selectivity for Aurora A than Aurora B. Alisertib induces cell cycle arrest, apoptosis and autophagy. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Luminespib (NVP-AUY922) 25mg 747412-49-3 AUY-922
Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90?/? with IC50 of 13 nM /21 nM in cell-free assays, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Luminespib (AUY-922, NVP-AUY922) effectively downregulates and destabilizes the IGF-1R? protein and results in growth inhibition, autophagy and apoptosis. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.