Custom Enzymes and Inhibitors
Selleck Chemical LLC PD98059 10mM/1mL 167869-21-8
PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 ?M in a cell-free assay, specifically inhibits MEK-1-mediated activation of MAPK; does not directly inhibit ERK1 or ERK2. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR) and functions as an AHR antagonist. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Raltitrexed 10mg 112887-68-0 ZD-1694
Raltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Lamivudine 10mg 134678-17-4 GR109714X
Lamivudine (GR109714X) is a potent nucleoside analog reverse transcriptase inhibitor, used for treatment of chronic HBV and HIV/AIDS. It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Ondansetron HCl 10mg 99614-01-4 GR 38032F
Ondansetron HCl (GR 38032F) is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Apexbio Technology LLC Aloperine, 500mg. Cas: 56293-29-9 MFCD: MFCD00468086. An alkaloid
Aloperine is exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties. 56293-29-9. MFCD00468086
Apexbio Technology LLC Y-27632, 146986-50-7, MFCD03093855, 10 mg
MF: C14H21N3O, MW: 247.34, Solubility: 24.7mg/mL in DMSO,insoluble in Chloroform. Y-27632 is a specific inhibitor of Rho-associated kinases(ROCK) family with Ki values of 0.22uM and 0.30uM for ROCK1 and ROCK2, respectively.
Apexbio Technology LLC DBeQ, 177355-84-9, MFCD03691820, 10 mg
MF: C22H20N4, MW: 340.42, Solubility: 16mg/mL in DMSO. DBeQ is a selective and reversible inhibitor of p97 ATPase (IC50 = 1.5 uM) which induces caspase-3 and caspase-7 rapidly.
Apexbio Technology LLC Esomeprazole Sodium, 10mg. Cas: 161796-78-7 MFCD: MFCD07802816. Proton pump inhibitor
Esomeprazole sodium (Nexium) is the S-isomer of omeprazole and acts as a proton pump inhibitor. 161796-78-7. MFCD07802816
Apexbio Technology LLC Potent and selective Aurora A Kinase inhibitor 1028486-01-2. MFCD16621243
Potent and selective Aurora A Kinase inhibitor 1028486-01-2. MFCD16621243
Apexbio Technology LLC BI 2536 5MG
BI 2536 (CAS number 755038-02-9) is an ATP-competitive inhibitor selectively targeting human polo-like kinase 1 (PLK1) exhibiting an IC50 value of approximately 0 83 nM Comparatively BI 2536 shows substantially less affinity towards other kinases In vitro studies demonstrate that BI 2536 inhibits proliferation of various human tumor cell lines (EC50 values ranging from 2 to 25 nM) and induces G2/M cell cycle arrest accompanied by apoptosis as evidenced in HeLa cervical cancer cells In vivo data from xenograft tumor models indicate that BI 2536 administered intravenously on a weekly or biweekly schedule possesses antitumor efficacy
Apexbio Technology LLC ICG 001, 10mg. Cas: 847591-62-2 MFCD: MFCD12196918. Wnt/β-catenin pathway inhibitor
Wnt/ Beta -catenin pathway inhibitor blocking Beta -catenin/CBP interaction 847591-62-2. MFCD12196918
Apexbio Technology LLC KU-60019 925701-49-1 10mg
KU-60019 is a selective inhibitor targeting ataxia telangiectasia mutated (ATM) kinase with an IC50 value of approximately 6 3 nM Through inhibition of ATM kinase activity KU-60019 influences cellular DNA damage responses and sensitivity to radiation therapy It has been demonstrated to enhance radiosensitivity in human fibroblast cells expressing functional ATM but not in ATM-deficient cells Additionally KU-60019 reduces radiation-induced phosphorylation of AKT at Ser473 in glioma cell lines independently affecting cell migration invasion and proliferation KU-60019 serves as an investigational tool for exploring ATM-dependent signaling pathways and examining therapeutic strategies against cancers involving ATM-regulated DNA repair and cell survival mechanisms
Biotang Inc BIIB021, CNF2024, Free Base, > 99%, 25MG, M.W. 318.76, C14H15ClN6O, CAS#848695-25-0
BIIB021, CNF2024, Free Base, > 99%, 25MG, M.W. 318.76, C14H15ClN6O, CAS#848695-25-0
Ace Glass, Inc. 500mL GL32 top #50 bottom peptide vessel body, 2mm bore PTFE stopcock side port
500ML GL32 NO.50 PEPT BODY
Selleck Chemical LLC Nutlin-3 25mg 890090-75-2
Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM in a cell-free assay; stabilizes p73 in p53-deficient cells. *For Research & Development use only. Product is not intended for drug, household, or human consumption.