Custom Peptides
Cayman Chemical Isoalntolacton 10mg
A topoisomerase II-a poison inhibits topoisomerase II-a by 78.9 at 20 UM selective for topoisomerase II-a over topoisomerase I providing 100 and 0 inhibition respectively at 100 UM inhibits proliferation of HCT15 T47D DU145 and HeLa cancer cells (IC50s 0.014 0.00267 0.072 and 2.46 UM respectively) induces apoptosis in T47D cells at 10 and 30 UM reduces tumor growth in an MDA-MB-231 orthotopic mouse model of breast cancer at 12 mg/kg per day
Cayman Chemical ButenafIn13Cd3hydrochLR 10mg
A CAIX inhibitor (Ki 0.007 UM for the recombinant human enzyme) selective for CAIX over CAI and CAII but does inhibit CAXII (Kis 5.6 0.55 and 0.002 UM respectively) inhibits proliferation of HT-29 and MDA-MB-231 but not HCT116 cancer cells under anoxic conditions (IC50s 20 481 and 1000 UM respectively) reduces the number of lung metastases but not primary tumor growth in an MDA-MB-231 mouse xenograft model at 10 mg/kg
Cayman Chemical BenzetImIdehydrochlorIde 10mg
An AChE inhibitor (IC50 1.6 UM for rat stomach enzyme) and a prokinetic agent induces contractions in isolated rabbit duodenum from 1-100 UM enhances ACh-induced contractions in isolated guinea pig stomach circular muscle strips enhances normal gastric antral motility and improves clonidine-induced gastric antral hypomotility and delayed gastric emptying in rats at 100 mg/kg
Cayman Chemical Ocmum gratsmum Pperton 10mg
A citrullinated form of AB40 exhibits increased transient formation of soluble oligomers and insoluble aggregates composed of distorted parallelBsheets compared with unmodified AB40
Cayman Chemical ZolIflodacIn 10mg
A bile acid a metabolite of 7b-hydroxy cholesterol in rats conjugated forms have been found in the urine of patients with Neimann-Pick disease type C
Cayman Chemical Lnraplenb 10mg
A B2-adrenergic receptor agonist an active metabolite of bambuterol binds to B1- B2- and B3-ARs (Ki 31.3 15.4 and 79.8 nM respectively) selectively increases adenylyl cyclase activity in CHO cell membranes expressing recombinant human B2- or B3- over B1-ARs at concentrations 100-fold greater than the respective Ki values inhibits airway obstruction induced by methacholine or LTD4 in anesthetized guinea pigs
Cayman Chemical Pexacerfont 10mg
A muscarinic receptor antagonist (IC50s 2.9 2 and 1.7 nM for M1 M2 and M3 receptors respectively) inhibits acetylcholine-induced bronchospasm in anesthetized guinea pigs (EC50 68 g/ml) prevents increases in airway resistance in a rat model of cadmium inhalation-induced chronic pulmonary inflammation with airspace enlargement at 0.2 mg/20 ml aerosolized and reduces neutrophil counts and total cell numbers in BALF and airspace enlargement in lungs when administered in combination with formoterol
Cayman Chemical EnoxacIn-d8hydrochlorIde 10mg
An internal standard for the quantification of miconazole by GC- or LC-MS
Cayman Chemical VoxIlaprevIr 10mg
A cholesterol precursor increases the percentage of MBP oligodendrocytes formed from oligodendrocyte precursor cells at 5.8 and 17 UM
Cayman Chemical CefoselIsulfate 10mg
A heterocyclic building block has been used to synthesize phenoxazine derivatives
Cayman Chemical NIcotInamID rIbosIDd4trI 10mg
An internal standard for the quantification of PGE1 by GC- or LC-MS
Cayman Chemical TerbuthylazIn 10mg
An FFAR2/GPR43 positive allosteric modulator (EC50 0.42 UM for [35S]GTPYS binding to 293 T-REx cell membranes expressing the human receptor) selectively induces ERK1/2 phosphorylation in 293 T-REx cells expressing human FFAR2 but not FFAR1 or FFAR3
Cayman Chemical SWAY100135hydrochLRIde 10mg
A Plk1 inhibitor (IC50 2 nM) inhibits 95 of Plk1 activity but also inhibits the activity of 10 additional kinases by greater than or equal to 90 in a panel of 359 kinases at 1 UM reduces H3S10Ph in HT-29 colorectal cancer cells (EC30 9 nM) inhibits proliferation in a panel of six human lymphoma cell lines (IC50 3.2-24 nM)
Cayman Chemical FaropenmsodIM salt hydrat 10mg
A volatile sesquiterpene hydrocarbon with pheromonal and kairomonal activities produced by aphids in response to predator or parasite attack induces dispersion of 50 of M. persicae aphids from a cluster at 0.2 ng attracts larvae and adults of A. bipunctata at 2 g