Custom Peptides
Cayman Chemical C17 CeramIded18 117 0 10mg
A synthetic ceramide; contains a non-natural C17:0 fatty acid acylated to sphingosine; has been used as a marker of arylsulfatase A and sphingolipid activator B activity
Cayman Chemical CeralIfImod 10mg
An agonist of S1P1 and S1P5 receptors (Kis = 0.626 and 0.574 nM, respectively); selective for S1P1 and S1P5 over S1P2-4 (Kis = >5,450, >5,630, and 28.8 nM, respectively); induces calcium influx in CHO-K1 cells overexpressing S1P1 (EC50 = 1 nM) and cAMP accumulation in CHO-K1 cells overexpressing S1P1 or S1P5 (EC50s = 0.027 and 0.33 nM, respectively); reduces paw edema in a rat model of CIA at 0.03 and 0.1 mg/kg; delays disease onset and inhibits lymphocyte infiltration of the spinal cord in a rat model of EAE; prevents disease relapse in a non-obese diabetic mouse model of relapsing-remitting EAE
Cayman Chemical XE 991hydrochlorIde 10mg
A blocker of KCNQ channels that potently inhibits KCNQ1 and 2 homomeric channels (IC50 = 0.75 and 0.71 µM, respectively) as well as KCNQ2+3 heteromultimers (IC50 = 0.6 µM); shows good in vivo potency and duration of action
Cayman Chemical FluphenazIn decnoate 10mg
A prodrug form of fluphenazine; induces random mouth movements in rats; increases serum levels of prolactin and decreases LH and FSH, as well as decreases desire to mate and litter size, in male rats at 3 mg/kg per day; It increases lethargy and passive contact and reduces self-grooming, social grooming, auditory startle response, and propensity to attack other animals in monkeys
Cayman Chemical AbarelIxacetate 10mg
A synthetic GnRHR antagonist (IC50 = 3.5 nM); decreases plasma LH levels six hours post-treatment in castrated rats, with levels returning to baseline within 24 hour at 200 μg/kg; transiently decreases plasma testosterone levels in intact rats, with levels returning to baseline within seven days post-treatment at 2 mg/kg
Cayman Chemical Metergoln 10mg
A serotonin receptor antagonist active at 5-HT1 (pKi = 7.8 for 5-HT1B), 5-HT2, (pKi = 8.64, 8.75, and 8.75 for 5-HT2A, 5-HT2B, and 5-HT2C respectively), and 5-HT7 receptors; blocks 5-HT7 receptor-stimulated cAMP production (IC50 = 321 nM); dose-dependently inhibits voltage-dependent sodium and potassium channels
Cayman Chemical ARUK2001607 10mg
A PI5P4Kγ inhibitor (IC50 = 0.079 µM for PI5P4Kγ+, a construct with mutations conferring increased functional activity); selectively binds to PI5P4Kγ (Kd = 7.1 nM) over 22 other lipid kinases but does bind to PIP5K1C (Kd = 230 nM); selective for PI5P4Kγ over PI5P4Kα and PI5P4Kβ (IC50s = >15.8 and >25.1 µM, respectively); selective for PI5P4Kγ over 138 other kinases in a kinase panel and a variety of receptors, enzymes, and ion channels in a safety panel at 10 µM but does inhibit Aurora B kinase and CLK2 by 31 and 37% and dopamine uptake by 59% at 10 µM
Cayman Chemical Esmolol-d7hydrochlorIde 10mg
An internal standard for the quantification of esmolol by GC- or LC-MS
Cayman Chemical 25C-NBOHhydrochlorIde 10mg
A derivative of 2C-C having an N-(2-hydroxybenzyl) addition at the amine; a potent agonist of serotonin receptors that shows selectivity for 5-HT2A over 5-HT2C (EC50s = ~ 0.40 and 15 nM, respectively); intended for forensic and research applications
Cayman Chemical Aldosteron 10mg
A steroid hormone secreted by the adrenal cortex that controls sodium and potassium balance
Cayman Chemical JWH 122 8mthylnaphthyl 10mg
Differs from JWH 122 in that the methyl group is attached to the naphthyl rings at the 8, rather than the 4, position
Cayman Chemical BrImonIdIntartrate 10mg
An α2-AR agonist (Kis = 2.7, 52, and 44 nM for α2A, α2B, and α2C-ARs, respectively, in CHO cells); selective for α2-ARs over α1-ARs (Ki = 1,800 nM in human brain); lowers intraocular pressure in DBA/2J mice to control levels at 0.1% applied topically to the eye; protects rat retinal ganglion cells against glutamate excitotoxicity in a rat model of retinal ischemia at 1 mg/kg per day
Cayman Chemical SCH 79797hydrochlorIde 10mg
A non-peptide antagonist of PAR1; blocks binding of haTRAP (IC50 = 70 nM) as well as platelet aggregation induced by either haTRAP or α-thrombin (IC50 = 0.3 and 3 µM, respectively); has no activity against PAR2, PAR4, or other receptors involved in platelet activation
Cayman Chemical DynorphIn BtrIfluoROCTAte 10mg
A 13-residue opioid peptide that acts as an endogenous κ1b-opioid receptor agonist (Ki = 1.1 nM); has been implicated in antinociceptive functions and has also been used to prime cardiogenesis in pluripotent embryonic stem cells
Cayman Chemical VU6036720hydrochlorIde 10mg
An inhibitor of heteromeric Kir4.1/5.1 channels (IC50 = 0.24 µM); selective for Kir4.1/5.1 channels over a variety of homomeric Kir channels, including Kir4.1 (IC50 = >10 µM), as well as heteromeric Kir3.1/3.2, Kir3.1/3.4, Kir6.2/SUR1, and Kir6.1/SUR2b channels at 30 µM but does inhibit the voltage-gated potassium channel Kv1.1 (IC50 = 6.4 µM); does not inhibit diuresis in mice at 30 and 100 mg/kg due to low oral bioavailability and high hepatic clearance