Custom Peptides
Cayman Chemical Preladenant 10mg
An adenosine A2A receptor antagonist (Kis = 1.1 and 2.5 nM for human and rat receptors, respectively); selective for A2A receptors over A1, A2B, and A3 receptors, with Ki values greater than 1,000 nM, and a panel of receptors enzymes and ion channels; inhibits A2A receptor agonist-induced adenylate cyclase activity (Kbs = 1.3 and 0.7 nM for human and rat receptors, respectively); inhibits catalepsy induced by haloperidol in rats by 77 and 70% after 1 and 4 hours, respectively (1 mg/kg); increases the efficacy of L-DOPA when used in combination with eltoprazine
Cayman Chemical Tenatoprazole 10mg
A proton pump inhibitor, blocking hog gastric H+/K+-ATPase activity with an IC50 value of 6.2 µM; blocks induced gastric acid secretion and ulcer formation in rats and humans
Cayman Chemical NortrIptylInhydrochlorIde 10mg
A tricyclic antidepressant that blocks norepinephrine and serotonin transporters (KDs = 4.4 and 18 nM, respectively) more potently than the dopamine transporter (KD = 1.1 µM)
Cayman Chemical 13 14dIhdro15keto Prostag 10mg
Prominent plasma metabolite of PGF2α in the 15-hydroxy PGDH pathway
Cayman Chemical LCysteInglutathIon dIsulf 10mg
A glutathione derivative endogenous to mammalian cells that is comprised of the oxidized form of free glutathione tripeptide linked via a disulfide bond to L-cysteine; protects mice against acetaminophen-induced hepatotoxicity
Cayman Chemical 16phenoxy trnor Prostagla 10mg
16-phenoxy tetranor PGE2 is the free acid form of sulprostone formed by the hydrolysis of the methylsulfonamide bond.{3387} 16-phenoxy tetranor PGE2 is a minor metabolite of sulprostone found in human plasma after parenteral administration of the drug.{3387}
Cayman Chemical -SKF 81297hydrobromIde 10mg
A selective agonist of the dopamine D1-like receptor (Ki = 1.9 nM) that demonstrates comparatively lower binding affinity for the dopamine D2, dopamine D3, serotonin 5-HT2A, and adrenergic α2 receptors (Kis = 1,272, >10,000, 955, and 509 nM, respectively)
Cayman Chemical Aldosteron 10mg
A steroid hormone secreted by the adrenal cortex that controls sodium and potassium balance
Cayman Chemical TolterodIntartrate 10mg
A muscarinic acetylcholine receptor antagonist (Kis = 1.4, 2.7, 3.6, 3.1, and 2.2 nM for M1-5 receptors, respectively); reduces carbachol-induced intracellular calcium mobilization in bladder smooth muscle cells and submandibular gland cells isolated from cynomolgus monkeys (Kis = 3.16 and 2 nM, respectively); inhibits volume-induced bladder contractions and oxotremorine-induced salivation in rats (ID50s = 0.025 and 0.12 mg/kg, respectively)
Cayman Chemical LY2835219methnsulfonate 10mg
An orally-bioavailable dual inhibitor of CDK4 and CDK6 (IC50s = 2 and 10 nM, respectively); has antitumor action against xenografts when used alone or in combination with other chemotherapeutic compounds
Cayman Chemical ZonIporIdehydrochlorIde 10mg
Selectively inhibits human NHE-1 with an IC50 value of 14 nM; reduces infarct size in a rabbit myocardial ischemia-reperfusion model without adversely affecting hemodynamics or cardiac function
Cayman Chemical MInoxIdIl-d10 10mg
An internal standard for the quantification of minoxidil by GC- or LC-MS
Cayman Chemical RBI 257maleate 10mg
A potent dopamine D4 receptor antagonist (Ki = 0.3 nM) that is selective over D2L, D3, D2-like, and D1 receptors by 1,721-, 439-, 1,336-, and 8,576-fold, respectively.{28464}
Cayman Chemical ResmInostathydrochlorIde 10mg
An orally bioavailable inhibitor of HDAC1, HDAC3, and HDAC6 (IC50s = 43-72 nM), resulting in hyperacetylation of histone H4 in multiple myeloma cells; abrogates cell growth and strongly induces apoptosis in multiple myeloma cells (IC50s = 2.5-3 µM); dose-dependently inhibits HDAC activity in vivo
Cayman Chemical BS-181hydrochlorIde 10mg
A selective Cdk7 inhibitor that blocks the activity of Cdk-activating kinase (IC50 = 21 nM); inhibits the growth of cancer cell lines in vitro and MCF-7 human xenografts in nude mice