Custom Peptides
Cayman Chemical Gly-Pro-pNAhydrochlorIde 10mg
A chromogenic substrate that can be cleaved by DPP IV; enzyme activity can be quantified by colorimetric detection of free p-nitroanilide at 405 nm
Cayman Chemical 17phenyl trInor PrstglndI 10mg
17-phenyl trinor PGE2 is a synthetic analog of PGE2. It is an EP1 and EP3 receptor agonist.{3318,1025} 17-phenyl trinor PGE2 is an EP1 and EP3 receptor agonist.1,2 It causes contraction of the guinea pig ileum at a concentration of 11 µM.{3318} It is slightly less potent than PGE2 in stimulating gerbil colon and rat uterus.{1025} With an ED50 value of 350 UG/kg, 17-phenyl trinor PGE2 is 4.4 times more potent than PGE2 as an antifertility agent in hamsters.{1025}
Cayman Chemical TIrofIbnhydrochLRIde hydr 10mg
A GPIIb/IIIa antagonist (IC50 = 5 nM in a radioligand binding assay); inhibits GPIIb/IIIa-dependent platelet aggregation (IC50 = 11 nM); inhibits HUVEC attachment to microtiter plates containing Fg, Vn, or Fn at concentrations >10,000-fold above the IC50 for platelet aggregation; prevents occlusive thrombosis and reduces thrombus mass in a canine model of electrically-induced coronary artery occlusive thrombosis
Cayman Chemical ICI 118551hydrochlorIde 10mg
A potent, selective antagonist of the β2-adrenergic receptor (Ki = 0.7 nM for the β2 receptor, compared with 49.5 and 611 nM for β1 and β3 receptors, respectively); active in vivo and often used to evaluate the actions of adrenergic receptor agonists
Cayman Chemical MndIpropamId 10mg
A fungicide; inhibits cellulose synthesis and germ tube elongation in P. infestans at 68 nM; reduces mycelial growth of Phytophthora and P. litchi (EC50s = 0.008-0.03 mg/L); toxic to zebrafish embryos, larvae, and adults (LC50s = 19.91, 4.53, and 4.85 mg/L, respectively); has been used as a chemical inducer of proximity to study protein translocation in vitro and in vivo
Cayman Chemical 3-DeoxygunosIn 10mg
A ligand that can be complexed with enzymes, such as purine nucleoside phosphorylase, and receptors, such as G-coupled receptors, in order to study structure-activity relationships; also used to selectively impair transcription
Cayman Chemical 25C-NBOHhydrochlorIde 10mg
A derivative of 2C-C having an N-(2-hydroxybenzyl) addition at the amine; a potent agonist of serotonin receptors that shows selectivity for 5-HT2A over 5-HT2C (EC50s = ~ 0.40 and 15 nM, respectively); intended for forensic and research applications
Cayman Chemical EldecalcItol 10mg
A derivative of calcitriol; induces calcium release in an in vitro bone mobilization assay using isolated mouse calvaria at 10 nM; reduces LPS-induced pyroptosis and increases in hydrogen peroxide and protein levels of the NLRP3 inflammasome, caspase-1, and IL-1β in primary human gingival fibroblasts at 50 nM; induces apoptosis and cell cycle arrest at the G0/G1 phase in, and inhibits migration of, SCC-15 and CAL 27 cells at 0.4 nM; decreases tumor volume in an SCC-15 mouse xenograft model at 0.5 UG/kg twice per week; decreases serum PTH levels and increases serum calcium levels, bone mineral density, and bone strength in a cynomolgus monkey model of osteoporosis induced by ovariectomy at 0.3 UG/kg
Cayman Chemical 5 7 3 4 5Pentamethoxyflav 10mg
A flavonoid with diverse biological activities; inhibits pancreatic lipase in a cell-free assay; reduces lipid accumulation in 3T3-L1 adipocytes; inhibits transactivation of Nrf2 in a reporter assay using HEK293T cells at 10, 25, or 50 µM; sensitizes cisplatin-resistant A549 NSCLC cells to cisplatin; inhibits LPS-induced NO production in RAW 264.7 macrophages and GES-1 cells; decreases blood glucose levels and renal fibrosis in a rat model of STZ-induced diabetes at 5 mg/kg
Cayman Chemical Soyaspogenol B 10mg
A triterpenoid with diverse biological activities; inhibits LPS-induced increases in the levels of NO in RAW 264.7 macrophages at 95.6 µM; decreases triglyceride levels, as well as increases glycerol and free fatty acids levels in, and decreases the levels of resistin secreted from, 3T3-L1 adipocytes at 12.5 µM; reduces plasma levels of ALT in a mouse model of concanavalin A-induced autoimmune hepatitis
Cayman Chemical 3 3HydroxyphenylpropIonIc 10mg
A metabolite of certain phenols and glycosides; urinary excretion is reduced in C. parvum-infected protein-deficient mice and increased in mice fed wheat bran or functionalized wheat bran