Custom Peptides
Cayman Chemical Curcuma zedoara Curcumol 10mg
A sesquiterpene alcohol with diverse biological activities; a PAM of GABAA receptors that potentiates GABA-induced currents in hippocampal neurons; reduces activation of proinflammatory NF-κB and profibrotic TGF-β1/SMAD signaling pathways in RAW 264.7 cells stimulated with cigarette smoke extract from 1-200 μg/ml; inhibits proliferation of and induces apoptosis in LoVo and SW480 colorectal cancer cells; reduces tumor volume in a LoVo mouse xenograft model from 20-80 mg/kg; increases the rate of wound closure in rats with streptozotocin-induced diabetes
Cayman Chemical SynthetIc Uvaol 10mg
A pentacyclic triterpenoid; induces cell cycle arrest at the G0/G1 phase and inhibits proliferation of MCF-7 human breast cancer cells in a concentration-dependent manner; prevents hydrogen peroxide-induced DNA damage in the same cells; induces relaxation of phenylephrine- or potassium chloride-precontracted aortic rings isolated from spontaneously hypertensive rats at 100 µM; inhibits ovalbumin-induced BALF eosinophil infiltration in an ovalbumin-sensitized mouse model of allergic asthma
Cayman Chemical 1Stearoyl2Adrenoylsnglyc 10mg
A phospholipid; levels are inversely correlated with subject age in mitochondria isolated from human post-mortem hippocampus
Cayman Chemical OnjIsaponIn B 10mg
A triterpenoid saponin with neuroprotective activity; inhibits glutamate- or serum-starvation-induced neurotoxicity in PC12 cells at 10 μM; decreases amyloid-β production in HEK293/APPswe cells (IC50 = 10 μM); reduces spatial learning and memory deficits in the Morris water maze in an APP/PS1 transgenic mouse model of Alzheimer’s disease at 10 mg/kg per day; prevents D-galactose-induced decreases in hippocampal GSH levels and increases in hippocampal MDA, IL-1β, IL-6, and TNF-α levels in a rat model of D-galactose-induced aging at 10 and 20 mg/kg
Cayman Chemical CalIcheamIcIn 1 10mg
A polyketide enediyne; induces double-stranded DNA scission in cell-free assays
Cayman Chemical JWH 250 5hydroxyIndl meta 10mg
Expected to be a metabolite of JWH 250 that would be detectable both in serum and in urine; intended for research and forensic applications
Cayman Chemical SchaftosIde 10mg
A flavonoid C-glycoside with diverse biological activities; inhibits xanthine oxidase (IC50 = 51.4 μM) and has antioxidant activity in a β-carotene-linoleic acid bleaching assay (IC50 = 46.3 μM); inhibits neutrophil influx into mouse lung by 62% in a model of airway inflammation induced by aerosol administration of LPS at 400 μg/kg
Cayman Chemical N N NTrIacetylchItotrIose 10mg
A triose oligosaccharide derived from chitin; scavenges reactive oxygen species and protects DNA from oxidative damage
Cayman Chemical AcoramIdIshydrochlorIde 10mg
A TTR kinetic stabilizer; selectively binds to wild-type TTR and TTRV122I with negative cooperativity (Kd1s = 4.8 and 6.2 nM, respectively; Kd2s = 314 and 139 nM, respectively) over COX-1, COX-2, and the thyroid hormone nuclear receptor (IC50s = >10 µM for all); inhibits pH-induced amyloidogenesis of wild-type TTR and TTRV122I, indicating tetramer stabilization; stabilizes TTRV122I in serum isolated from patients with familial amyloid cardiomyopathy at 10 µM
Cayman Chemical ACTH7-38humntrIfluor 10mg
A peptide fragment of ACTH and an antagonist of MC2R; inhibits ACTH-induced corticosterone production in isolated rat adrenal cells at 0.455 or 4.55 µM; inhibits ACE1 (IC50 = 750 nM for the dog enzyme); inhibits basal cAMP secretion by isolated rat inner adrenocortical cells at 1 µM; induces hypotension in normotensive dogs (ED50 = 0.109 nmol/kg)
Cayman Chemical 1 2DIlInoleoyl3aLInolenoy 10mg
A triacylglycerol; has been found in corn and soybean oils
Cayman Chemical TrotabresIb 10mg
A BRD4 inhibitor (IC50 = =0.5 µM); inhibits the proliferation of Raji and HL-60 cells (IC50 = =0.5 µM for both)
Cayman Chemical EstropIpate 10mg
A piperazine salt form of estrone 3-sulfate; inhibits OATP1B1 selectively over OATP1B3 (IC50s = 0.06 and 19.32 µM, respectively)
Cayman Chemical 2C-TFMhydrochlorIde 10mg
A 2C compound with a para-trifluoromethyl substitution. It is a potent agonist of the 5-HT receptor subtypes 5-HT2A and 5-HT2C (Kaff = 165 and 32 nM); intended for forensic and research purposes
