Custom Peptides
Cayman Chemical SynthetIc AlysIn 10mg
An isothiocyanate with diverse biological activities; active against a variety of bacteria; directly inhibits PAH-induced CYP1A1 and CYP1A2 activity in MCF-7 cells at 0.5-2.5 µM; inhibits proliferation of HCT116 colon cancer cells (IC50 = 50s = 168 and 20 µM, respectively)
Cayman Chemical 14methyl PentadecnoIc ACD 10mg
A methylated fatty acid methyl ester; has been found in S. zeai sea sponges as the fatty acyl component of zeamide, A. indica leaf extract, and C. vulgaris and H. pluvialis microalgae; major component of the vancomycin-induced biofilm produced by VRSA; has been used as a standard for the quantification of 14-methyl pentadecanoic acid in various foods by GC-MS
Cayman Chemical 9-nthryldIazomethn 10mg
A fluorescent probe; has been used for the detection of fatty acids, arachidonic acid metabolites, prostaglandins, leukotrienes, and thromboxanes; ex/em = 365/412 nm in 80:20 solutions of acetonitrile:water and methanol:water; has been used to detect amino acids via HPLC with ex/em = 255/412 nm, respectively; has been used as a synthetic intermediate in the synthesis of anthracene-containing polymers
Cayman Chemical EcnoglutIde 10mg
A cAMP-biased peptide GLP-1R agonist; selectively induces cAMP accumulation over β-arrestin recruitment (EC50s = 0.018 and 1,300 nM, respectively) without inducing GLP-1R receptor internalization (EC50 = >10,000 nM) in cell-based assays using human GLP-1R; reduces fasting and post-prandial blood glucose levels in db/db mice at 0.15 mg/kg; reduces body weight and food intake in db/db mice at 0.05 mg/kg
Cayman Chemical ImazalIl-d5sulfate 10mg
An internal standard for the quantification of imazalil by GC- or LC-MS
Cayman Chemical OmapatrIlat 10mg
An orally bioavailable ACE and NEP inhibitor (IC50s = 1.7 and 5.3 nM, respectively, for the human enzymes); inhibits the angiotensin I-induced pressor response in normotensive rats (ED50 = 0.07 µmol/kg); lowers MAP in sodium-depleted spontaneously hypertensive rats at 30 µmol/kg; lowers MAP in rats when co-administered with bradykinin; increases tracheal plasma extravasation in a rat model of upper airway angioedema in a dose-dependent manner
Cayman Chemical SemaglutIdeacetate 10mg
A GLP-1R agonist (EC50 = 6.2 pM in a reporter assay using BHK cells expressing the human receptor); decreases blood glucose levels in the db/db mouse model of type 2 diabetes (ED50 = <2 nmol/kg); prevents decreases in the number of dopaminergic neurons in the substantia nigra and increases in lipid peroxidation in the substantia nigra and striatum, as well as improves motor coordination in the rotarod and footprint tests in a mouse model of Parkinson’s disease induced by MPTP at 25 nmol/kg; decreases neuronal loss in the hippocampal dentate gyrus and CA1 and CA3 regions and improves motor coordination and grip strength in the beam-walking and hanging wire tests, respectively, in a rat model of stroke induced by permanent MCAO at 10 nmol/kg every other day
Cayman Chemical AtrvastatIn lacton 10mg
An active metabolite of atorvastatin; inhibits HMG-CoA reductase (IC50 = 0.007 µM for the rat liver enzyme); inhibits CYP2C9.1, CYP2C9.3, and P-gp (IC50s = 16.8, 5.62, and 3.1-5.2 µM, respectively)
Cayman Chemical 5 Hydroxymethyl2deoxyurI 10mg
A nucleoside analog; inhibits the replication of murine S180 lung carcinoma cells and Ehrlich ascites mammary carcinoma cells (ED50s = 8.5 and 4 μM, respectively) and multiple human leukemia cell lines (IC50s = 1.7-5.8 μM); acts synergistically with 5-FU against HT-29, HCT116, PANC-1, and EKVX cancer cells; inhibits HSV-1 pyrimidine 2’-deoxyribonucleoside kinase (Ki = 3.5 μM) and reduces HSV-1 viral titer to 0.05% of the control at a concentration of 200 μM; a DNA adduct formed in response to oxidative stress
Cayman Chemical MTP 131acetate 10mg
A mitochondria-targeted peptide antioxidant; reduces tert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells from 0.001 to 1 nM; reduces infarct volume, hemispheric swelling, and GSH depletion in a mouse model of MCAO-induced acute cerebral ischemia at 2 mg/kg; increases survival, improves motor function, and decreases degeneration of the lumbar spinal cord in the SOD1G93A transgenic mouse model of ALS at 5 mg/kg; reduces albuminuria, urinary hydrogen peroxide levels, and mesangial matrix accumulation, as well as preserves superoxide production, in a db/db mouse model of diabetic nephropathy
Cayman Chemical N 2PocethylbetulIn amIde 10mg
An alkyne derivative of betulin; can be used for click chemistry applications
Cayman Chemical JWH 018 2naphthylN 1ethy 10mg
An isomer of JWH 018, differing by having the naphthyl group attached at the 2, rather than 1, position, as well as an ethylpropyl group in place of the pentyl chain; intended for research and forensic
Cayman Chemical CnabIpIperIdIethnon 10mg
A synthetic CB that binds to the CB receptors CB1 and CB2 with IC50 values of 591 and 968 nM, respectively; intended for forensic purposes and research applications
MULTISORB 3G CUT STRIPPAX 2,400/case
This item has a minimum order quantity of 8 cases per supplier requirements.
Cayman Chemical 4-CABhydrochlorIde 10mg
An analog of PCA; inhibits the reuptake of serotonin (IC50 = 330 nM) and dopamine (IC50 = 2.3 μM)